Predicting self-diffusion coefficients in semi-crystalline and amorphous solid dispersions using free volume theory

[Display omitted] The self-diffusion coefficient of active ingredients (AI) in polymeric solid dispersions is one of the essential parameters for the rational formulation design in life sciences. Measuring this parameter for products in their application temperature range can, however, be difficult...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2023-09, Vol.190, p.107-120
Hauptverfasser:	Mansuri, Ali, Völkel, Milan, Mihiranga, Dilshan, Feuerbach, Tim, Winck, Judith, Vermeer, Arnoldus W.P., Hoheisel, Werner, Thommes, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous polymers Diffusion Drug diffusion coefficient Fragility Free volume theory Molecular mobility Semi-crystalline polymers Solid dispersions
Online-Zugang:	Volltext
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