Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach

Fibroblast growth factor receptors (FGFRs) are transmembrane receptor tyrosine kinases that regulate multiple physiological processes. Aberrant activation of FGFR2 and FGFR3 has been linked to the pathogenesis of many tumor types, including cholangiocarcinoma and bladder cancer. Current therapies ta...

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Veröffentlicht in:	ACS medicinal chemistry letters 2023-03, Vol.14 (3), p.312-318
Hauptverfasser:	Nguyen, Minh H., Ye, Hai-Fen, Xu, Yao, Truong, Lisa, Horsey, April, Zhao, Peng, Styduhar, Evan D., Frascella, Michelle, Leffet, Lynn, Federowicz, Kelly, Behshad, Elham, Wang, Anlai, Zhang, Ke, Witten, Michael R., Qi, Chao, Jalluri, Ravi, Lai, Cheng-Tsung, Atasoylu, Onur, Harris, Jennifer J., Hess, Rodrigo, Lin, Luping, Zhang, Guofeng, Covington, Maryanne, Diamond, Sharon, Yao, Wenqing, Vechorkin, Oleg
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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