The 5‐HT2A/2C inverse agonist nelotanserin alleviates L‐DOPA‐induced dyskinesia in the MPTP‐lesioned marmoset

Nelotanserin is a serotonin 2A and 2C (5‐HT2A/2C) inverse agonist that was previously tested in the clinic for rapid‐eye movement sleep behaviour disorder and psychosis in patients with Parkinson's disease (PD) dementia. Its effect on L‐3,4‐dihydroxyphenylalanine (L‐DOPA)‐induced dyskinesia has...

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Veröffentlicht in:	The European journal of neuroscience 2024-03, Vol.59 (6), p.1169-1176
Hauptverfasser:	Kwan, Cynthia, Frouni, Imane, Bédard, Dominique, Hamadjida, Adjia, Nuara, Stephen G., Gourdon, Jim C., Huot, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT2A receptor Antagonism Basal ganglia Central nervous system diseases Dementia disorders Dihydroxyphenylalanine Drug dosages Dyskinesia Inverse agonists Levodopa L‐DOPA marmoset Movement disorders MPTP nelotanserin Neurodegenerative diseases Parkinson's disease parkinsonism Psychosis Sleep disorders
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