Serum C‐reactive protein concentrations in dogs with structural and idiopathic epilepsy
Background C‐reactive protein (CRP) is an acute‐phase protein produced by the liver during systemic inflammation. In humans, some epilepsies are associated with increased serum CRP (sCRP) concentrations, but this has yet to be proven in veterinary studies. Dogs with structural epilepsy (SE) and norm...
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| Veröffentlicht in: | Veterinary record 2023-12, Vol.193 (12), p.no-no |
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| creator | Mahon, Elizabeth K. Williams, Tim L. Alves, Lisa |
| description | Background
C‐reactive protein (CRP) is an acute‐phase protein produced by the liver during systemic inflammation. In humans, some epilepsies are associated with increased serum CRP (sCRP) concentrations, but this has yet to be proven in veterinary studies. Dogs with structural epilepsy (SE) and normal interictal neurological examination are hard to distinguish from dogs with idiopathic epilepsy (IE) without the use of advanced imaging.
Methods
The study included eight dogs with SE and 12 dogs with IE from a referral hospital population. This was a retrospective observational cohort study. The Mann–Whitney test was used to compare the sCRP concentrations within 24 hours of the last epileptic seizure between dogs with SE or IE.
Results
Dogs with SE had higher sCRP concentrations than dogs with IE (8.9 [range |
| doi_str_mv | 10.1002/vetr.3211 |
| format | Article |
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C‐reactive protein (CRP) is an acute‐phase protein produced by the liver during systemic inflammation. In humans, some epilepsies are associated with increased serum CRP (sCRP) concentrations, but this has yet to be proven in veterinary studies. Dogs with structural epilepsy (SE) and normal interictal neurological examination are hard to distinguish from dogs with idiopathic epilepsy (IE) without the use of advanced imaging.
Methods
The study included eight dogs with SE and 12 dogs with IE from a referral hospital population. This was a retrospective observational cohort study. The Mann–Whitney test was used to compare the sCRP concentrations within 24 hours of the last epileptic seizure between dogs with SE or IE.
Results
Dogs with SE had higher sCRP concentrations than dogs with IE (8.9 [range <2.2–53.2] mg/L vs. <2.2 [range <2.2–6.9] mg/L; p = 0.043). Five of the eight (62%) dogs with SE had an sCRP concentration above the reference interval, compared with none of the 12 dogs with IE.
Limitations
The small sample size was the major limitation of this study. Other inflammatory causes were also not exclusively ruled out, although further clinical investigations were not indicated.
Conclusions
This study found that sCRP concentrations were higher in this cohort of dogs with SE than in those with IE. Further studies with larger cohorts of dogs are warranted to validate if sCRP can be used as an additional biomarker for SE.</description><identifier>ISSN: 0042-4900</identifier><identifier>EISSN: 2042-7670</identifier><identifier>DOI: 10.1002/vetr.3211</identifier><identifier>PMID: 37503700</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; C-Reactive Protein - metabolism ; Cohort Studies ; Dog Diseases - etiology ; Dogs ; Epilepsy ; Epilepsy - diagnosis ; Epilepsy - veterinary ; Humans ; Proteins ; Seizures - veterinary</subject><ispartof>Veterinary record, 2023-12, Vol.193 (12), p.no-no</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd on behalf of British Veterinary Association.</rights><rights>2023 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3481-47036ad34135080ac0c69c49b29c728ed56ec8257a08753f6711ae4478c618ec3</cites><orcidid>0000-0002-3787-7020</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fvetr.3211$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fvetr.3211$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37503700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahon, Elizabeth K.</creatorcontrib><creatorcontrib>Williams, Tim L.</creatorcontrib><creatorcontrib>Alves, Lisa</creatorcontrib><title>Serum C‐reactive protein concentrations in dogs with structural and idiopathic epilepsy</title><title>Veterinary record</title><addtitle>Vet Rec</addtitle><description>Background
C‐reactive protein (CRP) is an acute‐phase protein produced by the liver during systemic inflammation. In humans, some epilepsies are associated with increased serum CRP (sCRP) concentrations, but this has yet to be proven in veterinary studies. Dogs with structural epilepsy (SE) and normal interictal neurological examination are hard to distinguish from dogs with idiopathic epilepsy (IE) without the use of advanced imaging.
Methods
The study included eight dogs with SE and 12 dogs with IE from a referral hospital population. This was a retrospective observational cohort study. The Mann–Whitney test was used to compare the sCRP concentrations within 24 hours of the last epileptic seizure between dogs with SE or IE.
Results
Dogs with SE had higher sCRP concentrations than dogs with IE (8.9 [range <2.2–53.2] mg/L vs. <2.2 [range <2.2–6.9] mg/L; p = 0.043). Five of the eight (62%) dogs with SE had an sCRP concentration above the reference interval, compared with none of the 12 dogs with IE.
Limitations
The small sample size was the major limitation of this study. Other inflammatory causes were also not exclusively ruled out, although further clinical investigations were not indicated.
Conclusions
This study found that sCRP concentrations were higher in this cohort of dogs with SE than in those with IE. Further studies with larger cohorts of dogs are warranted to validate if sCRP can be used as an additional biomarker for SE.</description><subject>Animals</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cohort Studies</subject><subject>Dog Diseases - etiology</subject><subject>Dogs</subject><subject>Epilepsy</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - veterinary</subject><subject>Humans</subject><subject>Proteins</subject><subject>Seizures - veterinary</subject><issn>0042-4900</issn><issn>2042-7670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kM1KHEEQgJugxI3JIS8gDV70sFr9M909x7CoCQiCmkBOTdtTqy2zM5PunpW9-Qg-o09ib1ZzCHiqovj4KD5CvjI4YgD8eIk5HgnO2Acy4SD5VCsNW2QC613WADvkU0r3Ba0rwT-SHaErEBpgQn5fYRwXdPb8-BTR-RyWSIfYZwwd9X3nscvR5dB3iZZL098m-hDyHU05jj6P0bXUdQ0NTegHl--CpziEFoe0-ky2565N-OV17pKfpyfXs-_T84uzH7Nv51MvpGFTqUEo1wjJRAUGnAevai_rG157zQ02lUJveKUdGF2JudKMOZRSG6-YQS92ycHGW97-M2LKdhGSx7Z1HfZjstxUUnJVcVPQ_f_Q-36MXfnO8hpYbZRSolCHG8rHPqWIczvEsHBxZRnYdW-77m3XvQu792ocbxbY_CPfAhfgeAM8lCqr903218n15V_lC0hEiqw</recordid><startdate>20231216</startdate><enddate>20231216</enddate><creator>Mahon, Elizabeth K.</creator><creator>Williams, Tim L.</creator><creator>Alves, Lisa</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3787-7020</orcidid></search><sort><creationdate>20231216</creationdate><title>Serum C‐reactive protein concentrations in dogs with structural and idiopathic epilepsy</title><author>Mahon, Elizabeth K. ; Williams, Tim L. ; Alves, Lisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3481-47036ad34135080ac0c69c49b29c728ed56ec8257a08753f6711ae4478c618ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cohort Studies</topic><topic>Dog Diseases - etiology</topic><topic>Dogs</topic><topic>Epilepsy</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - veterinary</topic><topic>Humans</topic><topic>Proteins</topic><topic>Seizures - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahon, Elizabeth K.</creatorcontrib><creatorcontrib>Williams, Tim L.</creatorcontrib><creatorcontrib>Alves, Lisa</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary record</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahon, Elizabeth K.</au><au>Williams, Tim L.</au><au>Alves, Lisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum C‐reactive protein concentrations in dogs with structural and idiopathic epilepsy</atitle><jtitle>Veterinary record</jtitle><addtitle>Vet Rec</addtitle><date>2023-12-16</date><risdate>2023</risdate><volume>193</volume><issue>12</issue><spage>no</spage><epage>no</epage><pages>no-no</pages><issn>0042-4900</issn><eissn>2042-7670</eissn><abstract>Background
C‐reactive protein (CRP) is an acute‐phase protein produced by the liver during systemic inflammation. In humans, some epilepsies are associated with increased serum CRP (sCRP) concentrations, but this has yet to be proven in veterinary studies. Dogs with structural epilepsy (SE) and normal interictal neurological examination are hard to distinguish from dogs with idiopathic epilepsy (IE) without the use of advanced imaging.
Methods
The study included eight dogs with SE and 12 dogs with IE from a referral hospital population. This was a retrospective observational cohort study. The Mann–Whitney test was used to compare the sCRP concentrations within 24 hours of the last epileptic seizure between dogs with SE or IE.
Results
Dogs with SE had higher sCRP concentrations than dogs with IE (8.9 [range <2.2–53.2] mg/L vs. <2.2 [range <2.2–6.9] mg/L; p = 0.043). Five of the eight (62%) dogs with SE had an sCRP concentration above the reference interval, compared with none of the 12 dogs with IE.
Limitations
The small sample size was the major limitation of this study. Other inflammatory causes were also not exclusively ruled out, although further clinical investigations were not indicated.
Conclusions
This study found that sCRP concentrations were higher in this cohort of dogs with SE than in those with IE. Further studies with larger cohorts of dogs are warranted to validate if sCRP can be used as an additional biomarker for SE.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>37503700</pmid><doi>10.1002/vetr.3211</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3787-7020</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals C-Reactive Protein - metabolism Cohort Studies Dog Diseases - etiology Dogs Epilepsy Epilepsy - diagnosis Epilepsy - veterinary Humans Proteins Seizures - veterinary |
| title | Serum C‐reactive protein concentrations in dogs with structural and idiopathic epilepsy |
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