Disruption of Ebola NP0VP35 Inclusion Body-like Structures reduce Viral Infection

•In vitro purified Ebola eNP0VP35 spontaneously phase separates, likely seeding early stages of viral IB assembly.•Construct screening illuminates key interactions within phase separated droplets.•Ebola IBs are composed of eNP0VP35 complexes and other key viral and host components.•Perturbation of e...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of molecular biology 2023-10, Vol.435 (20), p.168241, Article 168241
Hauptverfasser:	Wu, Chao, Wagner, Nicole D., Moyle, Austin B., Feng, Annie, Sharma, Nitin, Stubbs, Sarah H., Donahue, Callie, Davey, Robert A., Gross, Michael L., Leung, Daisy W., Amarasinghe, Gaya K.
Format:	Artikel
Sprache:	eng
Schlagworte:	biomolecular condensate Ebola inclusion body phase separation viral replication organelle
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!