Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus–Specific CD8 T-Cell Responses and High Anti–Hepatitis B Surface Antigen Titers

Abstract Hepatitis B Virus (HBV) is a major driver of infectious disease mortality. Curative therapies are needed and ideally should induce CD8 T cell-mediated clearance of infected hepatocytes plus anti-hepatitis B surface antigen (HBsAg) antibodies (anti-HBs) to neutralize residual virus. We devel...

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Veröffentlicht in:	The Journal of infectious diseases 2024-04, Vol.229 (4), p.1077-1087
Hauptverfasser:	Schmidt, Sarah, Mengistu, Meron, Daffis, Stephane, Ahmadi-Erber, Sarah, Deutschmann, Daniela, Grigoriev, Tetiana, Chu, Ruth, Leung, Cleo, Tomkinson, Adrian, Uddin, Mohammad Nizam, Moshkani, Safiehkhatoon, Robek, Michael D, Perry, Jason, Lauterbach, Henning, Orlinger, Klaus, Fletcher, Simon P, Balsitis, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens CD8 antigen Genotypes Hepatitis B surface antigen Hepatocytes Immunization Infectious diseases Lymphocytes T Viruses
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