Radiofrequency energy in the treatment of erectile dysfunction—a novel cohort pilot study on safety, applicability, and short-term efficacy
The erectile mechanism depends, in part on the intactness of the collagen components in the penis. As such, impaired collagen may have a deleterious effect on erectile function. Radiofrequency energy has been shown to renew and restore spatial structural arrangement of collagen fibers; therefore, tr...
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| description | The erectile mechanism depends, in part on the intactness of the collagen components in the penis. As such, impaired collagen may have a deleterious effect on erectile function. Radiofrequency energy has been shown to renew and restore spatial structural arrangement of collagen fibers; therefore, treatment of erectile dysfunction with radiofrequency could lead to anatomical and physiological changes at the penile tissue level and could lead to improvement in the erectile mechanism. We conducted this study to assess the effect of radiofrequency treatment on erection quality. We evaluated the safety, applicability, and efficacy of a self-applied, handheld, low-intensity radiofrequency device (Vertica®) in men with moderate and mild-to-moderate organic erectile dysfunction. The treatment protocol consisted of 12 treatments (twice a week during the 1st month, and once a week during the 2nd month), and each participant treated himself individually. Treatment outcomes were evaluated using the International Index of Erectile Function, Erection Hardness Scale, Erectile Dysfunction Index of Treatment Satisfaction, Benefit, Satisfaction & Willingness to continue, Quality of Erection Questionnaire, Sexual Quality of Life questionnaires and specific questions addressing side effects and ease of use. Twenty-eight out of 32 men (mean age 59.5 ± 9.8, range: 41–78 years) completed a one-month follow-up after treatment. Mean International Index of Erectile Function (43.7. ± 7.8 vs. 60.9 ± 10.8,
p
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| doi_str_mv | 10.1038/s41443-023-00733-1 |
| format | Article |
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p
< 0.01), International Index of Erectile Function -Erection Function domain (16.8 ± 3.1 vs. 24.4 ± 4.4,
p
< 0.001), and Erection Hardness Scores (2.2 ± 0.8 vs. 3.2 ± 0.5,
p
= 0.01) were all significantly improved. Fifty percent of patients achieved normal erectile function parameters according to the International Index of Erectile Function -Erection Function domain score >25. High mean scores were achieved in the Erectile Dysfunction Index of Treatment Satisfaction (76.8 ± 20.3), Benefit, Satisfaction & Willingness to continue (4.83 ± 1.1), Quality of Erection Questionnaire (73.4 ± 23.8), and Sexual Quality of Life (67 ± 29.4) questionnaires. No side effects were reported and participants rated the device as very comfortable, simple, and easy to operate.</description><identifier>ISSN: 0955-9930</identifier><identifier>ISSN: 1476-5489</identifier><identifier>EISSN: 1476-5489</identifier><identifier>DOI: 10.1038/s41443-023-00733-1</identifier><identifier>PMID: 37592175</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699 ; 692/699/2732 ; Adult ; Aged ; Collagen ; Erectile dysfunction ; Erectile Dysfunction - therapy ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Patient Satisfaction ; Penile Erection ; Pilot Projects ; Quality of Life ; Questionnaires ; Reproductive Medicine ; rology ; Surveys and Questionnaires ; Treatment Outcome ; Urology</subject><ispartof>International journal of impotence research, 2024-11, Vol.36 (7), p.728-733</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Limited.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-df6e483f693643d200ca7591233084250e40e67d0a36c1e0f1bd4dea28c49e9b3</citedby><cites>FETCH-LOGICAL-c419t-df6e483f693643d200ca7591233084250e40e67d0a36c1e0f1bd4dea28c49e9b3</cites><orcidid>0000-0001-8270-8069 ; 0000-0003-0330-2859</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41443-023-00733-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41443-023-00733-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37592175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruenwald, Ilan</creatorcontrib><creatorcontrib>Appel, Boaz</creatorcontrib><creatorcontrib>Shechter, Arik</creatorcontrib><creatorcontrib>Greenstein, Alexander</creatorcontrib><title>Radiofrequency energy in the treatment of erectile dysfunction—a novel cohort pilot study on safety, applicability, and short-term efficacy</title><title>International journal of impotence research</title><addtitle>Int J Impot Res</addtitle><addtitle>Int J Impot Res</addtitle><description>The erectile mechanism depends, in part on the intactness of the collagen components in the penis. As such, impaired collagen may have a deleterious effect on erectile function. Radiofrequency energy has been shown to renew and restore spatial structural arrangement of collagen fibers; therefore, treatment of erectile dysfunction with radiofrequency could lead to anatomical and physiological changes at the penile tissue level and could lead to improvement in the erectile mechanism. We conducted this study to assess the effect of radiofrequency treatment on erection quality. We evaluated the safety, applicability, and efficacy of a self-applied, handheld, low-intensity radiofrequency device (Vertica®) in men with moderate and mild-to-moderate organic erectile dysfunction. The treatment protocol consisted of 12 treatments (twice a week during the 1st month, and once a week during the 2nd month), and each participant treated himself individually. Treatment outcomes were evaluated using the International Index of Erectile Function, Erection Hardness Scale, Erectile Dysfunction Index of Treatment Satisfaction, Benefit, Satisfaction & Willingness to continue, Quality of Erection Questionnaire, Sexual Quality of Life questionnaires and specific questions addressing side effects and ease of use. Twenty-eight out of 32 men (mean age 59.5 ± 9.8, range: 41–78 years) completed a one-month follow-up after treatment. Mean International Index of Erectile Function (43.7. ± 7.8 vs. 60.9 ± 10.8,
p
< 0.01), International Index of Erectile Function -Erection Function domain (16.8 ± 3.1 vs. 24.4 ± 4.4,
p
< 0.001), and Erection Hardness Scores (2.2 ± 0.8 vs. 3.2 ± 0.5,
p
= 0.01) were all significantly improved. Fifty percent of patients achieved normal erectile function parameters according to the International Index of Erectile Function -Erection Function domain score >25. High mean scores were achieved in the Erectile Dysfunction Index of Treatment Satisfaction (76.8 ± 20.3), Benefit, Satisfaction & Willingness to continue (4.83 ± 1.1), Quality of Erection Questionnaire (73.4 ± 23.8), and Sexual Quality of Life (67 ± 29.4) questionnaires. No side effects were reported and participants rated the device as very comfortable, simple, and easy to operate.</description><subject>692/699</subject><subject>692/699/2732</subject><subject>Adult</subject><subject>Aged</subject><subject>Collagen</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Patient Satisfaction</subject><subject>Penile Erection</subject><subject>Pilot Projects</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Reproductive Medicine</subject><subject>rology</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><subject>Urology</subject><issn>0955-9930</issn><issn>1476-5489</issn><issn>1476-5489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9qFTEUh4Mo9lp9ARcScOOio8mczJ8spWgVCoLoOuQmJ23KTDImGWF2voA7n9AnMbe3KrhwEZJwvvNLDh8hTzl7yRmMr7LgQkDD2rrYANDwe2THxdA3nRjlfbJjsusaKYGdkEc53zDGJOP9Q3ICQydbPnQ78v2jtj66hF9WDGajGDBdbdQHWq6RloS6zBgKjY5iQlP8hNRu2a2hnmP4-e2HpiF-xYmaeB1ToYufYqG5rHajMdCsHZbtjOplmbzRez_522uwNB_4pmCaKTpXi2Z7TB44PWV8crefks9v33w6f9dcfrh4f_76sjGCy9JY16MYwfUSegG2ZczoOhFvAdgo2o6hYNgPlmnoDUfm-N4Ki7odjZAo93BKXhxzlxTr4Lmo2WeD06QDxjWrduxAikH2UNHn_6A3cU2h_k4Bb_uRgwBeqfZImRRzTujUkvys06Y4UwdZ6ihLVVnqVpY6ND27i173M9o_Lb_tVACOQK6lcIXp79v_if0Fr6WiVg</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Gruenwald, Ilan</creator><creator>Appel, Boaz</creator><creator>Shechter, Arik</creator><creator>Greenstein, Alexander</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8270-8069</orcidid><orcidid>https://orcid.org/0000-0003-0330-2859</orcidid></search><sort><creationdate>202411</creationdate><title>Radiofrequency energy in the treatment of erectile dysfunction—a novel cohort pilot study on safety, applicability, and short-term efficacy</title><author>Gruenwald, Ilan ; Appel, Boaz ; Shechter, Arik ; Greenstein, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-df6e483f693643d200ca7591233084250e40e67d0a36c1e0f1bd4dea28c49e9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/699</topic><topic>692/699/2732</topic><topic>Adult</topic><topic>Aged</topic><topic>Collagen</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Patient Satisfaction</topic><topic>Penile Erection</topic><topic>Pilot Projects</topic><topic>Quality of Life</topic><topic>Questionnaires</topic><topic>Reproductive Medicine</topic><topic>rology</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruenwald, Ilan</creatorcontrib><creatorcontrib>Appel, Boaz</creatorcontrib><creatorcontrib>Shechter, Arik</creatorcontrib><creatorcontrib>Greenstein, Alexander</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of impotence research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruenwald, Ilan</au><au>Appel, Boaz</au><au>Shechter, Arik</au><au>Greenstein, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiofrequency energy in the treatment of erectile dysfunction—a novel cohort pilot study on safety, applicability, and short-term efficacy</atitle><jtitle>International journal of impotence research</jtitle><stitle>Int J Impot Res</stitle><addtitle>Int J Impot Res</addtitle><date>2024-11</date><risdate>2024</risdate><volume>36</volume><issue>7</issue><spage>728</spage><epage>733</epage><pages>728-733</pages><issn>0955-9930</issn><issn>1476-5489</issn><eissn>1476-5489</eissn><abstract>The erectile mechanism depends, in part on the intactness of the collagen components in the penis. As such, impaired collagen may have a deleterious effect on erectile function. Radiofrequency energy has been shown to renew and restore spatial structural arrangement of collagen fibers; therefore, treatment of erectile dysfunction with radiofrequency could lead to anatomical and physiological changes at the penile tissue level and could lead to improvement in the erectile mechanism. We conducted this study to assess the effect of radiofrequency treatment on erection quality. We evaluated the safety, applicability, and efficacy of a self-applied, handheld, low-intensity radiofrequency device (Vertica®) in men with moderate and mild-to-moderate organic erectile dysfunction. The treatment protocol consisted of 12 treatments (twice a week during the 1st month, and once a week during the 2nd month), and each participant treated himself individually. Treatment outcomes were evaluated using the International Index of Erectile Function, Erection Hardness Scale, Erectile Dysfunction Index of Treatment Satisfaction, Benefit, Satisfaction & Willingness to continue, Quality of Erection Questionnaire, Sexual Quality of Life questionnaires and specific questions addressing side effects and ease of use. Twenty-eight out of 32 men (mean age 59.5 ± 9.8, range: 41–78 years) completed a one-month follow-up after treatment. Mean International Index of Erectile Function (43.7. ± 7.8 vs. 60.9 ± 10.8,
p
< 0.01), International Index of Erectile Function -Erection Function domain (16.8 ± 3.1 vs. 24.4 ± 4.4,
p
< 0.001), and Erection Hardness Scores (2.2 ± 0.8 vs. 3.2 ± 0.5,
p
= 0.01) were all significantly improved. Fifty percent of patients achieved normal erectile function parameters according to the International Index of Erectile Function -Erection Function domain score >25. High mean scores were achieved in the Erectile Dysfunction Index of Treatment Satisfaction (76.8 ± 20.3), Benefit, Satisfaction & Willingness to continue (4.83 ± 1.1), Quality of Erection Questionnaire (73.4 ± 23.8), and Sexual Quality of Life (67 ± 29.4) questionnaires. No side effects were reported and participants rated the device as very comfortable, simple, and easy to operate.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37592175</pmid><doi>10.1038/s41443-023-00733-1</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8270-8069</orcidid><orcidid>https://orcid.org/0000-0003-0330-2859</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/699 692/699/2732 Adult Aged Collagen Erectile dysfunction Erectile Dysfunction - therapy Humans Male Medicine Medicine & Public Health Middle Aged Patient Satisfaction Penile Erection Pilot Projects Quality of Life Questionnaires Reproductive Medicine rology Surveys and Questionnaires Treatment Outcome Urology |
| title | Radiofrequency energy in the treatment of erectile dysfunction—a novel cohort pilot study on safety, applicability, and short-term efficacy |
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