Updates on RPE cell damage in diabetic retinopathy (Review)

Diabetic retinopathy (DR) is a microvascular complication of diabetes. The retinal pigment epithelium (RPE) forms the outer layer of the blood-retinal barrier and serves a role in maintaining retinal function. RPE cell injury has been revealed in diabetic animal models, and high glucose (HG) levels...

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Veröffentlicht in:	Molecular medicine reports 2023-10, Vol.28 (4), Article 185
Hauptverfasser:	Li, Min, Tian, Meimei, Wang, Yuling, Ma, Huijie, Zhou, Yaru, Jiang, Xinli, Liu, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Apoptosis Cell adhesion & migration Cell death Cell growth Cell injury Cell proliferation Circular RNA Complications and side effects Cytokines Development and progression Diabetes Diabetes mellitus Diabetic retinopathy Drug development Epithelium Gene expression Genetic aspects GLP-1 receptor agonists Glucagon Glucagon-like peptide 1 Glucose transporter Health aspects Hesperidin Inflammation Kinases Metabolism Metformin MicroRNAs Microvasculature miRNA Mitochondria Non-coding RNA Oxidative stress Pathogenesis Physiological aspects Physiology Plant extracts Proteins Retina Retinal pigment epithelium Retinopathy RNA Therapeutic targets
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