Knockdown of BUB1 inhibits tumor necrosis factor‐α‐induced proliferation and migration of rheumatoid arthritis synovial fibroblasts by regulating PI3K /Akt pathway

BackgroundRheumatoid arthritis (RA) is a common disease with joint cartilage destruction. BUB1 Mitotic Checkpoint Serine/Threonine Kinase (BUB1) is abnormally expressed in synovial tissues of RA patients, but its effect on RA remains unclear. In this study, we explored the role of BUB1 in RA.Methods...

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Veröffentlicht in:	International journal of rheumatic diseases 2023-10, Vol.26 (10), p.2024-2030
Hauptverfasser:	He, Qian, Jia, Lanlan, Wang, Xiaowan, Feng, Dandan, Mao, Tongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Cell growth Cell migration Cell proliferation Cytokines Fibroblasts Inflammation Protein-serine/threonine kinase Reverse transcription Rheumatoid arthritis Transfection Tumor necrosis factor Tumor necrosis factor-TNF Wound healing
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