Demethylation of CDKN2A in systemic lupus erythematosus and rheumatoid arthritis: a blood biomarker for diagnosis and assessment of disease activity

Introduction/objectives Considering the phenotypic and serological heterogeneity of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), significant challenges may intervene with the precise diagnosis. In this regard, numerous studies have shown that changes in DNA methylation levels...

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Veröffentlicht in:	Clinical rheumatology 2023-12, Vol.42 (12), p.3387-3395
Hauptverfasser:	Gravand, Abdollah, Alesaeidi, Samira, Khoshbakht, Shahrouz, Saghaei, Mozhdeh, Kenarangi, Taiebe, Mosallaei, Meysam, Soosanabadi, Mohsen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Arthritis, Rheumatoid Autoimmune diseases Biomarkers Bisulfite bisulfites blood Cyclin-Dependent Kinase Inhibitor p16 - metabolism Demethylation Diagnosis Disease DNA DNA methylation Endonuclease Humans Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Lupus lupus erythematosus Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - genetics Medicine Medicine & Public Health Original Article pathogenesis Peripheral blood mononuclear cells phenotype prognosis Rheumatoid arthritis Rheumatology Statistical analysis Systemic lupus erythematosus
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