Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection

Transient blockade of glycine decarboxylase (GLDC) can restrict de novo pyrimidine synthesis, which is a well-described strategy for enhancing the host interferon response to viral infection and a target pathway for some licenced anti-inflammatory therapies. The aminothiol, cysteamine, is produced e...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-10, Vol.677, p.168-181
Hauptverfasser:	Fraser-Pitt, Douglas, Mercer, Derry K., Francis, Marie-Louise, Toledo-Aparicio, David, Smith, Daniel W., O'Neil, Deborah A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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