Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence
Chronic alcohol use induces innate immune genes, which activate the innate immune system. Neuroimmune regulatory proteins [e.g., Cluster of Differentiation 200 (CD200)] are immune response regulators and are involved in balancing the immune response. This study aimed to investigate the expression of...
Gespeichert in:
| Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 2023-12, Vol.113, p.21-25 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 25 |
|---|---|
| container_issue | |
| container_start_page | 21 |
| container_title | Alcohol (Fayetteville, N.Y.) |
| container_volume | 113 |
| creator | Chaturvedi, Abhishek Rao, Guruprasad Praharaj, Samir Kumar Guruprasad, Kanive Parashiva Pais, Vivek Sadacharan, Chakravarthy Marx |
| description | Chronic alcohol use induces innate immune genes, which activate the innate immune system. Neuroimmune regulatory proteins [e.g., Cluster of Differentiation 200 (CD200)] are immune response regulators and are involved in balancing the immune response. This study aimed to investigate the expression of CD200 on the surface of peripheral blood leukocytes in patients with alcohol use disorder and compare them with controls. Fifty male patients with alcohol use disorder were included in the study. A baseline assessment was done, and alcohol use history, craving, and withdrawal scores were collected. A 2-mL venous blood sample was collected from cases and controls for immunophenotyping of CD200. The control group consisted of 50 participants with similar socio-economic backgrounds. The cellular expression of CD200 on total leukocytes (median ± IQR) [39.94 (28.85, 50.01)] in cases was significantly lower compared to controls [45.07 (37.70, 51.69)] (U = 896, p = 0.015). Expression of CD200 on lymphocytes in cases was negatively correlated with years of heavy drinking and this was statistically significant (r = −0.321, p = 0.023). The study indicates that cellular expression of CD200 on the surface of peripheral blood leukocytes is reduced in alcohol-dependent patients. This reduction can contribute to exaggerated immune activity, release of pro-inflammatory cytokines, chronic microglial activation, neuroinflammation, and neurodegeneration in alcohol dependence.
•Chronic alcohol consumption leads to activation of the neuroimmune system.•Cluster of differentiation (CD200) is a neuroimmune-regulating protein.•Cellular expression of CD200 on leukocytes is reduced in alcohol-dependent individuals.•Reduced CD200 can contribute to an exaggerated immune response in alcohol dependence. |
| doi_str_mv | 10.1016/j.alcohol.2023.08.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2853942212</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0741832923002550</els_id><sourcerecordid>2853942212</sourcerecordid><originalsourceid>FETCH-LOGICAL-c341t-6c1ae22c8f9ff6e07bc14dd12b31aa4c42d31a1dc6305ef05abc6c8e2c2f85f03</originalsourceid><addsrcrecordid>eNqFkM1u1DAURi1ERYfCI4AssWGT9NpOHGeF0BRopUqVqnZtOfa16iETp_YE0bevRzN0waar-y3O_TuEfGJQM2DyfFOb0caHONYcuKhB1QDiDVkx1YlKKi7ekhV0DauU4P0peZ_zBgC6ruvfkVPRtX0re7kitxdoE5qMjuLfOWHOIU40erq-4AC05BlTmB8wmZEOY4yOjrj8jvZph5mGiR6voA5nnBxOFj-QE2_GjB-P9Yzc__xxt76srm9-Xa2_X1dWNGxXScsMcm6V772XCN1gWeMc44NgxjS24a4E5qwU0KKH1gxWWoXccq9aD-KMfD3MnVN8XDDv9DZki-NoJoxL1ly1om84Z7ygX_5DN3FJU7muUD0HAbJVhWoPlE0x54RezylsTXrSDPReut7o47t6L12D0kV66ft8nL4MW3QvXf8sF-DbAcCi40_ApLMNe1UuJLQ77WJ4ZcUzqzGVXw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2892030658</pqid></control><display><type>article</type><title>Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Chaturvedi, Abhishek ; Rao, Guruprasad ; Praharaj, Samir Kumar ; Guruprasad, Kanive Parashiva ; Pais, Vivek ; Sadacharan, Chakravarthy Marx</creator><creatorcontrib>Chaturvedi, Abhishek ; Rao, Guruprasad ; Praharaj, Samir Kumar ; Guruprasad, Kanive Parashiva ; Pais, Vivek ; Sadacharan, Chakravarthy Marx</creatorcontrib><description>Chronic alcohol use induces innate immune genes, which activate the innate immune system. Neuroimmune regulatory proteins [e.g., Cluster of Differentiation 200 (CD200)] are immune response regulators and are involved in balancing the immune response. This study aimed to investigate the expression of CD200 on the surface of peripheral blood leukocytes in patients with alcohol use disorder and compare them with controls. Fifty male patients with alcohol use disorder were included in the study. A baseline assessment was done, and alcohol use history, craving, and withdrawal scores were collected. A 2-mL venous blood sample was collected from cases and controls for immunophenotyping of CD200. The control group consisted of 50 participants with similar socio-economic backgrounds. The cellular expression of CD200 on total leukocytes (median ± IQR) [39.94 (28.85, 50.01)] in cases was significantly lower compared to controls [45.07 (37.70, 51.69)] (U = 896, p = 0.015). Expression of CD200 on lymphocytes in cases was negatively correlated with years of heavy drinking and this was statistically significant (r = −0.321, p = 0.023). The study indicates that cellular expression of CD200 on the surface of peripheral blood leukocytes is reduced in alcohol-dependent patients. This reduction can contribute to exaggerated immune activity, release of pro-inflammatory cytokines, chronic microglial activation, neuroinflammation, and neurodegeneration in alcohol dependence.
•Chronic alcohol consumption leads to activation of the neuroimmune system.•Cluster of differentiation (CD200) is a neuroimmune-regulating protein.•Cellular expression of CD200 on leukocytes is reduced in alcohol-dependent individuals.•Reduced CD200 can contribute to an exaggerated immune response in alcohol dependence.</description><identifier>ISSN: 0741-8329</identifier><identifier>EISSN: 1873-6823</identifier><identifier>DOI: 10.1016/j.alcohol.2023.08.003</identifier><identifier>PMID: 37595696</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Addiction ; Alcohol ; Alcohol use ; Alcoholism ; Antigens, CD - metabolism ; Cardiovascular disease ; CD200 ; CD200 antigen ; Cellular expression ; Chronic illnesses ; Cytokines ; Cytokines - metabolism ; Drinking behavior ; Drug dependence ; Humans ; Immune response ; Immune system ; Immunophenotyping ; Inflammation ; Innate immunity ; Leukocytes ; Leukocytes - metabolism ; Lymphocytes ; Male ; Mental disorders ; Neurodegeneration ; Peripheral blood ; Proteins ; Regulatory proteins ; Sociodemographics ; Statistical analysis</subject><ispartof>Alcohol (Fayetteville, N.Y.), 2023-12, Vol.113, p.21-25</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><rights>2023. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c341t-6c1ae22c8f9ff6e07bc14dd12b31aa4c42d31a1dc6305ef05abc6c8e2c2f85f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2892030658?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37595696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaturvedi, Abhishek</creatorcontrib><creatorcontrib>Rao, Guruprasad</creatorcontrib><creatorcontrib>Praharaj, Samir Kumar</creatorcontrib><creatorcontrib>Guruprasad, Kanive Parashiva</creatorcontrib><creatorcontrib>Pais, Vivek</creatorcontrib><creatorcontrib>Sadacharan, Chakravarthy Marx</creatorcontrib><title>Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence</title><title>Alcohol (Fayetteville, N.Y.)</title><addtitle>Alcohol</addtitle><description>Chronic alcohol use induces innate immune genes, which activate the innate immune system. Neuroimmune regulatory proteins [e.g., Cluster of Differentiation 200 (CD200)] are immune response regulators and are involved in balancing the immune response. This study aimed to investigate the expression of CD200 on the surface of peripheral blood leukocytes in patients with alcohol use disorder and compare them with controls. Fifty male patients with alcohol use disorder were included in the study. A baseline assessment was done, and alcohol use history, craving, and withdrawal scores were collected. A 2-mL venous blood sample was collected from cases and controls for immunophenotyping of CD200. The control group consisted of 50 participants with similar socio-economic backgrounds. The cellular expression of CD200 on total leukocytes (median ± IQR) [39.94 (28.85, 50.01)] in cases was significantly lower compared to controls [45.07 (37.70, 51.69)] (U = 896, p = 0.015). Expression of CD200 on lymphocytes in cases was negatively correlated with years of heavy drinking and this was statistically significant (r = −0.321, p = 0.023). The study indicates that cellular expression of CD200 on the surface of peripheral blood leukocytes is reduced in alcohol-dependent patients. This reduction can contribute to exaggerated immune activity, release of pro-inflammatory cytokines, chronic microglial activation, neuroinflammation, and neurodegeneration in alcohol dependence.
•Chronic alcohol consumption leads to activation of the neuroimmune system.•Cluster of differentiation (CD200) is a neuroimmune-regulating protein.•Cellular expression of CD200 on leukocytes is reduced in alcohol-dependent individuals.•Reduced CD200 can contribute to an exaggerated immune response in alcohol dependence.</description><subject>Addiction</subject><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Alcoholism</subject><subject>Antigens, CD - metabolism</subject><subject>Cardiovascular disease</subject><subject>CD200</subject><subject>CD200 antigen</subject><subject>Cellular expression</subject><subject>Chronic illnesses</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Drinking behavior</subject><subject>Drug dependence</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunophenotyping</subject><subject>Inflammation</subject><subject>Innate immunity</subject><subject>Leukocytes</subject><subject>Leukocytes - metabolism</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Neurodegeneration</subject><subject>Peripheral blood</subject><subject>Proteins</subject><subject>Regulatory proteins</subject><subject>Sociodemographics</subject><subject>Statistical analysis</subject><issn>0741-8329</issn><issn>1873-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkM1u1DAURi1ERYfCI4AssWGT9NpOHGeF0BRopUqVqnZtOfa16iETp_YE0bevRzN0waar-y3O_TuEfGJQM2DyfFOb0caHONYcuKhB1QDiDVkx1YlKKi7ekhV0DauU4P0peZ_zBgC6ruvfkVPRtX0re7kitxdoE5qMjuLfOWHOIU40erq-4AC05BlTmB8wmZEOY4yOjrj8jvZph5mGiR6voA5nnBxOFj-QE2_GjB-P9Yzc__xxt76srm9-Xa2_X1dWNGxXScsMcm6V772XCN1gWeMc44NgxjS24a4E5qwU0KKH1gxWWoXccq9aD-KMfD3MnVN8XDDv9DZki-NoJoxL1ly1om84Z7ygX_5DN3FJU7muUD0HAbJVhWoPlE0x54RezylsTXrSDPReut7o47t6L12D0kV66ft8nL4MW3QvXf8sF-DbAcCi40_ApLMNe1UuJLQ77WJ4ZcUzqzGVXw</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Chaturvedi, Abhishek</creator><creator>Rao, Guruprasad</creator><creator>Praharaj, Samir Kumar</creator><creator>Guruprasad, Kanive Parashiva</creator><creator>Pais, Vivek</creator><creator>Sadacharan, Chakravarthy Marx</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QG</scope><scope>7RV</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202312</creationdate><title>Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence</title><author>Chaturvedi, Abhishek ; Rao, Guruprasad ; Praharaj, Samir Kumar ; Guruprasad, Kanive Parashiva ; Pais, Vivek ; Sadacharan, Chakravarthy Marx</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-6c1ae22c8f9ff6e07bc14dd12b31aa4c42d31a1dc6305ef05abc6c8e2c2f85f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Addiction</topic><topic>Alcohol</topic><topic>Alcohol use</topic><topic>Alcoholism</topic><topic>Antigens, CD - metabolism</topic><topic>Cardiovascular disease</topic><topic>CD200</topic><topic>CD200 antigen</topic><topic>Cellular expression</topic><topic>Chronic illnesses</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Drinking behavior</topic><topic>Drug dependence</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunophenotyping</topic><topic>Inflammation</topic><topic>Innate immunity</topic><topic>Leukocytes</topic><topic>Leukocytes - metabolism</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Neurodegeneration</topic><topic>Peripheral blood</topic><topic>Proteins</topic><topic>Regulatory proteins</topic><topic>Sociodemographics</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaturvedi, Abhishek</creatorcontrib><creatorcontrib>Rao, Guruprasad</creatorcontrib><creatorcontrib>Praharaj, Samir Kumar</creatorcontrib><creatorcontrib>Guruprasad, Kanive Parashiva</creatorcontrib><creatorcontrib>Pais, Vivek</creatorcontrib><creatorcontrib>Sadacharan, Chakravarthy Marx</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Criminal Justice</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaturvedi, Abhishek</au><au>Rao, Guruprasad</au><au>Praharaj, Samir Kumar</au><au>Guruprasad, Kanive Parashiva</au><au>Pais, Vivek</au><au>Sadacharan, Chakravarthy Marx</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence</atitle><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle><addtitle>Alcohol</addtitle><date>2023-12</date><risdate>2023</risdate><volume>113</volume><spage>21</spage><epage>25</epage><pages>21-25</pages><issn>0741-8329</issn><eissn>1873-6823</eissn><abstract>Chronic alcohol use induces innate immune genes, which activate the innate immune system. Neuroimmune regulatory proteins [e.g., Cluster of Differentiation 200 (CD200)] are immune response regulators and are involved in balancing the immune response. This study aimed to investigate the expression of CD200 on the surface of peripheral blood leukocytes in patients with alcohol use disorder and compare them with controls. Fifty male patients with alcohol use disorder were included in the study. A baseline assessment was done, and alcohol use history, craving, and withdrawal scores were collected. A 2-mL venous blood sample was collected from cases and controls for immunophenotyping of CD200. The control group consisted of 50 participants with similar socio-economic backgrounds. The cellular expression of CD200 on total leukocytes (median ± IQR) [39.94 (28.85, 50.01)] in cases was significantly lower compared to controls [45.07 (37.70, 51.69)] (U = 896, p = 0.015). Expression of CD200 on lymphocytes in cases was negatively correlated with years of heavy drinking and this was statistically significant (r = −0.321, p = 0.023). The study indicates that cellular expression of CD200 on the surface of peripheral blood leukocytes is reduced in alcohol-dependent patients. This reduction can contribute to exaggerated immune activity, release of pro-inflammatory cytokines, chronic microglial activation, neuroinflammation, and neurodegeneration in alcohol dependence.
•Chronic alcohol consumption leads to activation of the neuroimmune system.•Cluster of differentiation (CD200) is a neuroimmune-regulating protein.•Cellular expression of CD200 on leukocytes is reduced in alcohol-dependent individuals.•Reduced CD200 can contribute to an exaggerated immune response in alcohol dependence.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37595696</pmid><doi>10.1016/j.alcohol.2023.08.003</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0741-8329 |
| ispartof | Alcohol (Fayetteville, N.Y.), 2023-12, Vol.113, p.21-25 |
| issn | 0741-8329 1873-6823 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2853942212 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Addiction Alcohol Alcohol use Alcoholism Antigens, CD - metabolism Cardiovascular disease CD200 CD200 antigen Cellular expression Chronic illnesses Cytokines Cytokines - metabolism Drinking behavior Drug dependence Humans Immune response Immune system Immunophenotyping Inflammation Innate immunity Leukocytes Leukocytes - metabolism Lymphocytes Male Mental disorders Neurodegeneration Peripheral blood Proteins Regulatory proteins Sociodemographics Statistical analysis |
| title | Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T15%3A07%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20expression%20of%20CD200%20on%20peripheral%20blood%20leukocytes%20in%20alcohol%20dependence&rft.jtitle=Alcohol%20(Fayetteville,%20N.Y.)&rft.au=Chaturvedi,%20Abhishek&rft.date=2023-12&rft.volume=113&rft.spage=21&rft.epage=25&rft.pages=21-25&rft.issn=0741-8329&rft.eissn=1873-6823&rft_id=info:doi/10.1016/j.alcohol.2023.08.003&rft_dat=%3Cproquest_cross%3E2853942212%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2892030658&rft_id=info:pmid/37595696&rft_els_id=S0741832923002550&rfr_iscdi=true |