Deferoxamine Therapy for Hemorrhagic Transformation Following Brain Ischemia
The risk of HT increases after reperfusion therapies, such as tissue plasminogen activator (tPA) and mechanical thrombectomy [3], and it limits the use of such therapies. When large enough to form a parenchymal hematoma, HT is associated with increased risk of death and disability [5]. [...]there ar...
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| Veröffentlicht in: | Translational stroke research 2024-12, Vol.15 (6), p.1015-1016 |
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| creator | Bah, Momodou G. Holste, Katherine G. Xi, Guohua Keep, Richard F. |
| description | The risk of HT increases after reperfusion therapies, such as tissue plasminogen activator (tPA) and mechanical thrombectomy [3], and it limits the use of such therapies. When large enough to form a parenchymal hematoma, HT is associated with increased risk of death and disability [5]. [...]there are extensive efforts to develop adjunct therapies to be given with tPA or thrombectomy to limit HT (e.g., NCT0222274, NCT05484154, NCT05035953). Hao, Z; Yang, C; Xiang, L; Wu, B; Liu, M. Risk factors for intracranial hemorrhage after mechanical thrombectomy: a systematic review and meta-analysis. Targeting pro-oxidant iron with deferoxamine as a treatment for ischemic stroke: safety and optimal dose selection in a randomized clinical trial. |
| doi_str_mv | 10.1007/s12975-023-01188-8 |
| format | Article |
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| subjects | Asymptomatic Biomedical and Life Sciences Biomedicine Blood-brain barrier Cardiology Comment Hematoma Hemorrhage Hyperglycemia Ischemia Neurology Neurosciences Neurosurgery Patients Stroke Traumatic brain injury Vascular Surgery |
| title | Deferoxamine Therapy for Hemorrhagic Transformation Following Brain Ischemia |
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