Discovery of N‑(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors

The JAK2V617F mutation leads to JAK2 autophosphorylation and activation of downstream pathways, eventually resulting in myelo­proliferative neoplasms (MPNs). Selective inhibitors showed advantages in terms of side effects; therefore, there is an urgent need to develop novel selective JAK2 inhibitors...

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Veröffentlicht in:	ACS medicinal chemistry letters 2023-08, Vol.14 (8), p.1113-1121
Hauptverfasser:	Tian, Yang, Qin, Songhui, Zhang, Fang, Luo, Jing, He, Xi, Sun, Yi, Yang, Tao
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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