Prognosis of repeat hepatectomy for liver transplantable hepatocellular carcinoma recurrence after hepatectomy: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)
Purpose Factors affecting the prognosis of repeat hepatectomy for transplantable hepatocellular carcinoma (HCC) recurrence after hepatectomy remain unclear. We aimed to clarify the prognostic factors for transplantable hepatocellular carcinoma recurrence after hepatectomy. Methods We included 1758 p...
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| Veröffentlicht in: | Langenbeck's archives of surgery 2023-08, Vol.408 (1), p.314-314, Article 314 |
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| creator | Ohira, Masahiro Kobayashi, Tsuyoshi Hamaoka, Michinori Abe, Tomoyuki Onoe, Takashi Inoue, Masashi Honmyo, Naruhiko Oishi, Koichi Ohdan, Hideki |
| description | Purpose
Factors affecting the prognosis of repeat hepatectomy for transplantable hepatocellular carcinoma (HCC) recurrence after hepatectomy remain unclear. We aimed to clarify the prognostic factors for transplantable hepatocellular carcinoma recurrence after hepatectomy.
Methods
We included 1758 primary and 486 repeat hepatectomies out of 2244 for HCC performed between 2006 and 2017 using the Hiroshima Study Group for Clinical Oncology and Surgery database. We first compared survival rates of primary and repeat hepatectomy patients. Subsequently, prognostic factors were analyzed in patients who underwent a repeat hepatectomy for transplantable hepatocellular carcinoma recurrence after hepatectomy (defined as age 20 mm, and multiple tumors were independent prognostic risk factors for overall survival. Patients with two or more risk factors had a significantly lower survival rate (only 30.6% at 5 years) compared to those with one or fewer risk factors (81.8% at 5 years).
Conclusions
We identified the risk factors involved in post-hepatectomy survival for patients with transplantable recurrence after hepatectomy. The results are a potential indicator of whether salvage liver transplantation should be considered during repeat hepatectomy. |
| doi_str_mv | 10.1007/s00423-023-03057-2 |
| format | Article |
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Factors affecting the prognosis of repeat hepatectomy for transplantable hepatocellular carcinoma (HCC) recurrence after hepatectomy remain unclear. We aimed to clarify the prognostic factors for transplantable hepatocellular carcinoma recurrence after hepatectomy.
Methods
We included 1758 primary and 486 repeat hepatectomies out of 2244 for HCC performed between 2006 and 2017 using the Hiroshima Study Group for Clinical Oncology and Surgery database. We first compared survival rates of primary and repeat hepatectomy patients. Subsequently, prognostic factors were analyzed in patients who underwent a repeat hepatectomy for transplantable hepatocellular carcinoma recurrence after hepatectomy (defined as age < 70 years at the time of recurrence and recurrent tumor morphology that meets the Milan criteria).
Results
The 5-year overall survival rate (OS) after repeat hepatectomy was 63.2%, while the 5-year recurrence-free survival rate (RFS) was 23.7%. RFS demonstrated significant inferiority in the repeat hepatectomy group than in the primary hepatectomy group; however, OS did not present a notable difference between the two cohorts. In the transplantable recurrence group, mALBI grade 2b, max tumor size > 20 mm, and multiple tumors were independent prognostic risk factors for overall survival. Patients with two or more risk factors had a significantly lower survival rate (only 30.6% at 5 years) compared to those with one or fewer risk factors (81.8% at 5 years).
Conclusions
We identified the risk factors involved in post-hepatectomy survival for patients with transplantable recurrence after hepatectomy. The results are a potential indicator of whether salvage liver transplantation should be considered during repeat hepatectomy.</description><identifier>ISSN: 1435-2451</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-023-03057-2</identifier><identifier>PMID: 37584772</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Aged ; Carcinoma, Hepatocellular - pathology ; Cardiac Surgery ; General Surgery ; Hepatectomy - methods ; Humans ; Liver Neoplasms - pathology ; Medical Oncology ; Medicine ; Medicine & Public Health ; Neoplasm Recurrence, Local - pathology ; Prognosis ; Retrospective Studies ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2023-08, Vol.408 (1), p.314-314, Article 314</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c342t-bf82f5cc7ea7d4f5e385a9a5885592c71607b56e3488ef374e2d41b1b5b13f373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-023-03057-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-023-03057-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37584772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohira, Masahiro</creatorcontrib><creatorcontrib>Kobayashi, Tsuyoshi</creatorcontrib><creatorcontrib>Hamaoka, Michinori</creatorcontrib><creatorcontrib>Abe, Tomoyuki</creatorcontrib><creatorcontrib>Onoe, Takashi</creatorcontrib><creatorcontrib>Inoue, Masashi</creatorcontrib><creatorcontrib>Honmyo, Naruhiko</creatorcontrib><creatorcontrib>Oishi, Koichi</creatorcontrib><creatorcontrib>Ohdan, Hideki</creatorcontrib><creatorcontrib>Hiroshima Surgical study group of Clinical Oncology (HiSCO)</creatorcontrib><creatorcontrib>Hiroshima Surgical study group of Clinical Oncology (HiSCO)</creatorcontrib><title>Prognosis of repeat hepatectomy for liver transplantable hepatocellular carcinoma recurrence after hepatectomy: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Purpose
Factors affecting the prognosis of repeat hepatectomy for transplantable hepatocellular carcinoma (HCC) recurrence after hepatectomy remain unclear. We aimed to clarify the prognostic factors for transplantable hepatocellular carcinoma recurrence after hepatectomy.
Methods
We included 1758 primary and 486 repeat hepatectomies out of 2244 for HCC performed between 2006 and 2017 using the Hiroshima Study Group for Clinical Oncology and Surgery database. We first compared survival rates of primary and repeat hepatectomy patients. Subsequently, prognostic factors were analyzed in patients who underwent a repeat hepatectomy for transplantable hepatocellular carcinoma recurrence after hepatectomy (defined as age < 70 years at the time of recurrence and recurrent tumor morphology that meets the Milan criteria).
Results
The 5-year overall survival rate (OS) after repeat hepatectomy was 63.2%, while the 5-year recurrence-free survival rate (RFS) was 23.7%. RFS demonstrated significant inferiority in the repeat hepatectomy group than in the primary hepatectomy group; however, OS did not present a notable difference between the two cohorts. In the transplantable recurrence group, mALBI grade 2b, max tumor size > 20 mm, and multiple tumors were independent prognostic risk factors for overall survival. Patients with two or more risk factors had a significantly lower survival rate (only 30.6% at 5 years) compared to those with one or fewer risk factors (81.8% at 5 years).
Conclusions
We identified the risk factors involved in post-hepatectomy survival for patients with transplantable recurrence after hepatectomy. The results are a potential indicator of whether salvage liver transplantation should be considered during repeat hepatectomy.</description><subject>Abdominal Surgery</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cardiac Surgery</subject><subject>General Surgery</subject><subject>Hepatectomy - methods</subject><subject>Humans</subject><subject>Liver Neoplasms - pathology</subject><subject>Medical Oncology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><issn>1435-2451</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O0zAUhSMEYn7gBVggL4dFwL-xyw5FMEUaqYjCOnLcm9Yj1w62A-pj8kbjkIJmxeLK9vV3jnx9quoVwW8JxvJdwphTVuO5GBaypk-qS8KZqCkX5Omj_UV1ldI9xriRK_68umBSKC4lvax-f4lh70OyCYUBRRhBZ3SAUWcwORxPaAgROfsTIspR-zQ67bPuHSxQMODc5HRERkdjfTjqYmKmGMEbQHrIRfjI7j3S6CvkGNJYGsUWteEQYkbbPO1O6JfNB5QPgNa2IAdb3LZT3Fuj3Zm4jWEa56e2zvo__Y03wYX9Cd2s7bbdvHlRPRu0S_DyvF5X3z99_Nau67vN7ef2w11tGKe57gdFB2GMBC13fBDAlNArLZQSYkWNJA2WvWiAcaVgYJID3XHSk170hJUzu65uFt8xhh8TpNwdbZq_Q3sIU-qoEkQ1iuKmoHRBTZkqRRi6MZbZ4qkjuJuj7JYoOzzXHGVHi-j12X_qj7D7J_mbXQHYAqRy5fcQu_swRV9m_p_tAxR7rwk</recordid><startdate>20230816</startdate><enddate>20230816</enddate><creator>Ohira, Masahiro</creator><creator>Kobayashi, Tsuyoshi</creator><creator>Hamaoka, Michinori</creator><creator>Abe, Tomoyuki</creator><creator>Onoe, Takashi</creator><creator>Inoue, Masashi</creator><creator>Honmyo, Naruhiko</creator><creator>Oishi, Koichi</creator><creator>Ohdan, Hideki</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230816</creationdate><title>Prognosis of repeat hepatectomy for liver transplantable hepatocellular carcinoma recurrence after hepatectomy: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)</title><author>Ohira, Masahiro ; Kobayashi, Tsuyoshi ; Hamaoka, Michinori ; Abe, Tomoyuki ; Onoe, Takashi ; Inoue, Masashi ; Honmyo, Naruhiko ; Oishi, Koichi ; Ohdan, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-bf82f5cc7ea7d4f5e385a9a5885592c71607b56e3488ef374e2d41b1b5b13f373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdominal Surgery</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cardiac Surgery</topic><topic>General Surgery</topic><topic>Hepatectomy - methods</topic><topic>Humans</topic><topic>Liver Neoplasms - pathology</topic><topic>Medical Oncology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohira, Masahiro</creatorcontrib><creatorcontrib>Kobayashi, Tsuyoshi</creatorcontrib><creatorcontrib>Hamaoka, Michinori</creatorcontrib><creatorcontrib>Abe, Tomoyuki</creatorcontrib><creatorcontrib>Onoe, Takashi</creatorcontrib><creatorcontrib>Inoue, Masashi</creatorcontrib><creatorcontrib>Honmyo, Naruhiko</creatorcontrib><creatorcontrib>Oishi, Koichi</creatorcontrib><creatorcontrib>Ohdan, Hideki</creatorcontrib><creatorcontrib>Hiroshima Surgical study group of Clinical Oncology (HiSCO)</creatorcontrib><creatorcontrib>Hiroshima Surgical study group of Clinical Oncology (HiSCO)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohira, Masahiro</au><au>Kobayashi, Tsuyoshi</au><au>Hamaoka, Michinori</au><au>Abe, Tomoyuki</au><au>Onoe, Takashi</au><au>Inoue, Masashi</au><au>Honmyo, Naruhiko</au><au>Oishi, Koichi</au><au>Ohdan, Hideki</au><aucorp>Hiroshima Surgical study group of Clinical Oncology (HiSCO)</aucorp><aucorp>Hiroshima Surgical study group of Clinical Oncology (HiSCO)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognosis of repeat hepatectomy for liver transplantable hepatocellular carcinoma recurrence after hepatectomy: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2023-08-16</date><risdate>2023</risdate><volume>408</volume><issue>1</issue><spage>314</spage><epage>314</epage><pages>314-314</pages><artnum>314</artnum><issn>1435-2451</issn><eissn>1435-2451</eissn><abstract>Purpose
Factors affecting the prognosis of repeat hepatectomy for transplantable hepatocellular carcinoma (HCC) recurrence after hepatectomy remain unclear. We aimed to clarify the prognostic factors for transplantable hepatocellular carcinoma recurrence after hepatectomy.
Methods
We included 1758 primary and 486 repeat hepatectomies out of 2244 for HCC performed between 2006 and 2017 using the Hiroshima Study Group for Clinical Oncology and Surgery database. We first compared survival rates of primary and repeat hepatectomy patients. Subsequently, prognostic factors were analyzed in patients who underwent a repeat hepatectomy for transplantable hepatocellular carcinoma recurrence after hepatectomy (defined as age < 70 years at the time of recurrence and recurrent tumor morphology that meets the Milan criteria).
Results
The 5-year overall survival rate (OS) after repeat hepatectomy was 63.2%, while the 5-year recurrence-free survival rate (RFS) was 23.7%. RFS demonstrated significant inferiority in the repeat hepatectomy group than in the primary hepatectomy group; however, OS did not present a notable difference between the two cohorts. In the transplantable recurrence group, mALBI grade 2b, max tumor size > 20 mm, and multiple tumors were independent prognostic risk factors for overall survival. Patients with two or more risk factors had a significantly lower survival rate (only 30.6% at 5 years) compared to those with one or fewer risk factors (81.8% at 5 years).
Conclusions
We identified the risk factors involved in post-hepatectomy survival for patients with transplantable recurrence after hepatectomy. The results are a potential indicator of whether salvage liver transplantation should be considered during repeat hepatectomy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37584772</pmid><doi>10.1007/s00423-023-03057-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Langenbeck's archives of surgery, 2023-08, Vol.408 (1), p.314-314, Article 314 |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Abdominal Surgery Aged Carcinoma, Hepatocellular - pathology Cardiac Surgery General Surgery Hepatectomy - methods Humans Liver Neoplasms - pathology Medical Oncology Medicine Medicine & Public Health Neoplasm Recurrence, Local - pathology Prognosis Retrospective Studies Thoracic Surgery Traumatic Surgery Vascular Surgery |
| title | Prognosis of repeat hepatectomy for liver transplantable hepatocellular carcinoma recurrence after hepatectomy: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO) |
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