Development of a novel Fc fusion protein dual glucagon‐like peptide‐1 and gastric inhibitory polypeptide receptor agonists

Aim To develop and investigate an imbalanced dual gastric inhibitory polypeptide receptor (GIPR)/glucagon‐like peptide‐1 receptor (GLP‐1 R) agonist with Fc fusion protein structure. Methods We designed and constructed an Fc fusion protein that is a dual agonist (HEC‐CG115) with an empirically optimi...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2023-11, Vol.25 (11), p.3356-3365
Hauptverfasser:	Jiang, Peng, Sun, Ningyuan, Yang, Wen, Xiao, Lin, Zhou, Linjun, Gu, Baohua, Li, Yong, Li, Lijia, Li, Jing, Li, Xiaoping, Li, Wenjia, Guo, Linfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animal models Body weight loss Diabetes mellitus (non-insulin dependent) Diet Fc receptors Fusion protein GIP GLP‐1 Glucagon glycaemic control Hemoglobin Obesity obesity therapy Polypeptides Protein structure Proteins Toxicity weight control
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