Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis

Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis

COVID-19 patients demonstrating hyperactive immunologic response appear to have a severe illness with a poor prognosis. This study hypothesizes that the pro-inflammatory Annexin A2 (ANXA2) has role in COVID-19 pathogenesis. In thisobservational study, serum levels of ANXA2 along with interleukin 1 b...

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Veröffentlicht in:Immunobiology (1979) 2023-09, Vol.228 (5), p.152728-152728, Article 152728
Hauptverfasser: Shenoy, Rathika D., Nithin Kuriakose, Vijaykrishnaraj M., Patil, Prakash, Jayaswamy, Pavan K., Alagundagi, Dhananjay B., Shetty, Praveenkumar
Format: Artikel
Sprache:eng
Schlagworte:
Annexins
COVID-19
Cytokine
Inflammation
Interleukins
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Zusammenfassung:COVID-19 patients demonstrating hyperactive immunologic response appear to have a severe illness with a poor prognosis. This study hypothesizes that the pro-inflammatory Annexin A2 (ANXA2) has role in COVID-19 pathogenesis. In thisobservational study, serum levels of ANXA2 along with interleukin 1 beta (IL1β), IL6, tumour necrosis factor-alpha (TNFα), and anti-inflammatory ANXA1 were determined by sandwich ELISA in 20 each control, mild, moderate, and severe COVID-19 subjects.The ANXA2 levels (130 ng/mL, p 
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2023.152728