Novel antimicrobial iodo-dihydro-pyrrole-2-one compounds
A series of new hybrid molecules with two iodine atoms on the sides were synthesized. A one-pot, two-component method with trifluoroacetic acid as an effective catalyst to obtain dihydro-pyrrol-2-one compounds was developed. Short reaction times, a cheap catalyst, high yields and clean work-up are b...
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| Veröffentlicht in: | Future medicinal chemistry 2023-08, Vol.15 (15), p.1369-1391 |
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| container_title | Future medicinal chemistry |
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| creator | Al-Matarneh, Cristina M Nicolescu, Alina Marinas, Ioana C Chifiriuc, Mariana C Shova, Sergiu Silion, Mihaela Pinteala, Mariana |
| description | A series of new hybrid molecules with two iodine atoms on the sides were synthesized.
A one-pot, two-component method with trifluoroacetic acid as an effective catalyst to obtain dihydro-pyrrol-2-one compounds was developed. Short reaction times, a cheap catalyst, high yields and clean work-up are benefits of this method.
The chemical structures of the newly synthesized compounds were verified through spectroscopic techniques. Their antimicrobial activity against
,
and
was tested
.
NC- and OH- radicals confer broad-spectrum antimicrobial activity, including against Gram-positive and Gram-negative bacteria and yeasts. Compounds
>
and >
were most active on the two bacterial species, while
>
and >
were most active against the fungal strain. |
| doi_str_mv | 10.4155/fmc-2023-0121 |
| format | Article |
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A one-pot, two-component method with trifluoroacetic acid as an effective catalyst to obtain dihydro-pyrrol-2-one compounds was developed. Short reaction times, a cheap catalyst, high yields and clean work-up are benefits of this method.
The chemical structures of the newly synthesized compounds were verified through spectroscopic techniques. Their antimicrobial activity against
,
and
was tested
.
NC- and OH- radicals confer broad-spectrum antimicrobial activity, including against Gram-positive and Gram-negative bacteria and yeasts. Compounds
>
and >
were most active on the two bacterial species, while
>
and >
were most active against the fungal strain.</description><identifier>ISSN: 1756-8919</identifier><identifier>EISSN: 1756-8927</identifier><identifier>DOI: 10.4155/fmc-2023-0121</identifier><identifier>PMID: 37577781</identifier><language>eng</language><publisher>England: Newlands Press Ltd</publisher><subject>antimicrobial activity ; dihydro-pyrrol-2-one ; Doebner-type synthesis ; iodo-derivatives</subject><ispartof>Future medicinal chemistry, 2023-08, Vol.15 (15), p.1369-1391</ispartof><rights>2023 Newlands Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c306t-9e7e03536e3c0c62b0882eaf49037d12c36675d44e3cd7be4115a7ec01ce71033</citedby><cites>FETCH-LOGICAL-c306t-9e7e03536e3c0c62b0882eaf49037d12c36675d44e3cd7be4115a7ec01ce71033</cites><orcidid>0000-0002-7342-5398 ; 0000-0001-9299-1347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37577781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Matarneh, Cristina M</creatorcontrib><creatorcontrib>Nicolescu, Alina</creatorcontrib><creatorcontrib>Marinas, Ioana C</creatorcontrib><creatorcontrib>Chifiriuc, Mariana C</creatorcontrib><creatorcontrib>Shova, Sergiu</creatorcontrib><creatorcontrib>Silion, Mihaela</creatorcontrib><creatorcontrib>Pinteala, Mariana</creatorcontrib><title>Novel antimicrobial iodo-dihydro-pyrrole-2-one compounds</title><title>Future medicinal chemistry</title><addtitle>Future Med Chem</addtitle><description>A series of new hybrid molecules with two iodine atoms on the sides were synthesized.
A one-pot, two-component method with trifluoroacetic acid as an effective catalyst to obtain dihydro-pyrrol-2-one compounds was developed. Short reaction times, a cheap catalyst, high yields and clean work-up are benefits of this method.
The chemical structures of the newly synthesized compounds were verified through spectroscopic techniques. Their antimicrobial activity against
,
and
was tested
.
NC- and OH- radicals confer broad-spectrum antimicrobial activity, including against Gram-positive and Gram-negative bacteria and yeasts. Compounds
>
and >
were most active on the two bacterial species, while
>
and >
were most active against the fungal strain.</description><subject>antimicrobial activity</subject><subject>dihydro-pyrrol-2-one</subject><subject>Doebner-type synthesis</subject><subject>iodo-derivatives</subject><issn>1756-8919</issn><issn>1756-8927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kD1PwzAQhi0Eoqh0ZEUdWQz-iO1kRBVfUgULzJZjX4RREgc7Qeq_x1VKN7ycT_fcK92D0BUltwUV4q7pLGaEcUwooyfogiohcVkxdXr802qBVil9kfw4KyspztGCK6GUKukFKl_DD7Rr04--8zaG2pt27YML2PnPnYsBD7sYQwuY4dDD2oZuCFPv0iU6a0ybYHWoS_Tx-PC-ecbbt6eXzf0WW07kiCtQQLjgErglVrKalCUD0xQV4cpRZrmUSriiyHOnaigoFUaBJdSCooTzJbqZc4cYvidIo-58stC2pocwJc1KQRRVTFYZxTOa70gpQqOH6DsTd5oSvfelsy-996X3vjJ_fYie6g7ckf6zk4FqBpppnCIk66G3oOcub3jre_gn_BdaVHhX</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Al-Matarneh, Cristina M</creator><creator>Nicolescu, Alina</creator><creator>Marinas, Ioana C</creator><creator>Chifiriuc, Mariana C</creator><creator>Shova, Sergiu</creator><creator>Silion, Mihaela</creator><creator>Pinteala, Mariana</creator><general>Newlands Press Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7342-5398</orcidid><orcidid>https://orcid.org/0000-0001-9299-1347</orcidid></search><sort><creationdate>20230801</creationdate><title>Novel antimicrobial iodo-dihydro-pyrrole-2-one compounds</title><author>Al-Matarneh, Cristina M ; Nicolescu, Alina ; Marinas, Ioana C ; Chifiriuc, Mariana C ; Shova, Sergiu ; Silion, Mihaela ; Pinteala, Mariana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-9e7e03536e3c0c62b0882eaf49037d12c36675d44e3cd7be4115a7ec01ce71033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>antimicrobial activity</topic><topic>dihydro-pyrrol-2-one</topic><topic>Doebner-type synthesis</topic><topic>iodo-derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Matarneh, Cristina M</creatorcontrib><creatorcontrib>Nicolescu, Alina</creatorcontrib><creatorcontrib>Marinas, Ioana C</creatorcontrib><creatorcontrib>Chifiriuc, Mariana C</creatorcontrib><creatorcontrib>Shova, Sergiu</creatorcontrib><creatorcontrib>Silion, Mihaela</creatorcontrib><creatorcontrib>Pinteala, Mariana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Future medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Matarneh, Cristina M</au><au>Nicolescu, Alina</au><au>Marinas, Ioana C</au><au>Chifiriuc, Mariana C</au><au>Shova, Sergiu</au><au>Silion, Mihaela</au><au>Pinteala, Mariana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel antimicrobial iodo-dihydro-pyrrole-2-one compounds</atitle><jtitle>Future medicinal chemistry</jtitle><addtitle>Future Med Chem</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>15</volume><issue>15</issue><spage>1369</spage><epage>1391</epage><pages>1369-1391</pages><issn>1756-8919</issn><eissn>1756-8927</eissn><abstract>A series of new hybrid molecules with two iodine atoms on the sides were synthesized.
A one-pot, two-component method with trifluoroacetic acid as an effective catalyst to obtain dihydro-pyrrol-2-one compounds was developed. Short reaction times, a cheap catalyst, high yields and clean work-up are benefits of this method.
The chemical structures of the newly synthesized compounds were verified through spectroscopic techniques. Their antimicrobial activity against
,
and
was tested
.
NC- and OH- radicals confer broad-spectrum antimicrobial activity, including against Gram-positive and Gram-negative bacteria and yeasts. Compounds
>
and >
were most active on the two bacterial species, while
>
and >
were most active against the fungal strain.</abstract><cop>England</cop><pub>Newlands Press Ltd</pub><pmid>37577781</pmid><doi>10.4155/fmc-2023-0121</doi><tpages>23</tpages><orcidid>https://orcid.org/0000-0002-7342-5398</orcidid><orcidid>https://orcid.org/0000-0001-9299-1347</orcidid></addata></record> |
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| ispartof | Future medicinal chemistry, 2023-08, Vol.15 (15), p.1369-1391 |
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| language | eng |
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| source | PubMed Central |
| subjects | antimicrobial activity dihydro-pyrrol-2-one Doebner-type synthesis iodo-derivatives |
| title | Novel antimicrobial iodo-dihydro-pyrrole-2-one compounds |
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