Novel antimicrobial iodo-dihydro-pyrrole-2-one compounds

A series of new hybrid molecules with two iodine atoms on the sides were synthesized. A one-pot, two-component method with trifluoroacetic acid as an effective catalyst to obtain dihydro-pyrrol-2-one compounds was developed. Short reaction times, a cheap catalyst, high yields and clean work-up are benefits of this method. The chemical structures of the newly synthesized compounds were verified through spectroscopic techniques. Their antimicrobial activity against , and was tested . NC- and OH- radicals confer broad-spectrum antimicrobial activity, including against Gram-positive and Gram-negative bacteria and yeasts. Compounds > and > were most active on the two bacterial species, while > and > were most active against the fungal strain.