Development of palm-sized differential plasmon resonance meter based on concept of Sprode

A palm-sized differential surface plasmon resonance (SPR) meter, which consisted of a single light source, a prism, a divided mirror, and a single linear CCD element, was developed aiming at the miniaturization of an SPR instrument for use in field analysis of endocrine disrupting chemicals. The siz...

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Veröffentlicht in:Sensors and actuators. B, Chemical Chemical, 2005-07, Vol.108 (1), p.893-898
Hauptverfasser: Hemmi, Akihide, Imato, Toshihiko, Aoki, Yoshio, Sato, Masahiro, Soh, Nobuaki, Asano, Yasukazu, Akasaka, Chika, Okutani, Saeko, Ohkubo, Satoshi, Kaneki, Noriaki, Shimada, Koji, Eguchi, Tetsuya, Oinuma, Toshiaki
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container_issue 1
container_start_page 893
container_title Sensors and actuators. B, Chemical
container_volume 108
creator Hemmi, Akihide
Imato, Toshihiko
Aoki, Yoshio
Sato, Masahiro
Soh, Nobuaki
Asano, Yasukazu
Akasaka, Chika
Okutani, Saeko
Ohkubo, Satoshi
Kaneki, Noriaki
Shimada, Koji
Eguchi, Tetsuya
Oinuma, Toshiaki
description A palm-sized differential surface plasmon resonance (SPR) meter, which consisted of a single light source, a prism, a divided mirror, and a single linear CCD element, was developed aiming at the miniaturization of an SPR instrument for use in field analysis of endocrine disrupting chemicals. The size and weight of the meter were 160 cm ( W) × 10 cm ( H) × 6 cm ( D) and 770 g, respectively. The SPR meter composed of an Sprode with the sample and reference sensor-cells was found to be very effective for compensating drift and fluctuation of sensor signals as well as temperature variation at the same time without time lag. The effectiveness was due to a subtraction function of reference signal from the sample signal. The basic performance of the meter was a drift of within 0.001° in SPR measurement over 4300 s and a angle stability of within 0.0004° at a 10° incident LED light beam. Also, the SPR meter was applied to the immunoassay of 2,4-dichlorophenol (2,4-DCP) using a solid extraction technique. A good linear relationship between the concentration of 2,4-DCP and the SPR signal was obtained with the present meter. It was possible to determine 10 ppb of 2,4-DCP with the developed meter. A new concept of a divided mirror and the Sprode was thought to be useful for miniaturization of the SPR instrument aimed at on-site analysis.
doi_str_mv 10.1016/j.snb.2004.12.103
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1873-3077
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source Elsevier ScienceDirect Journals
subjects 2,4-Dichlorophenol
Charge coupled devices
Drift
Immunoassay
Measuring instruments
Meters
Miniaturization
Mobile
On-site analysis
Plasmons
Sensor
Sensors
Solid extraction
Surface plasmon resonance
Time lag
title Development of palm-sized differential plasmon resonance meter based on concept of Sprode
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