Human skin stem cell-derived hepatic cells as in vitro drug discovery model for insulin-driven de novo lipogenesis

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is characterized by intrahepatic triglyceride accumulation and can progress to metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis. Hepatic de novo li...

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Veröffentlicht in:	European journal of pharmacology 2023-10, Vol.957, p.175989-175989, Article 175989
Hauptverfasser:	Buyl, Karolien, Vrints, Martine, Fernando, Ruani, Desmae, Terry, Van Eeckhoutte, Thomas, Jans, Mia, Van Der Schueren, Jan, Boeckmans, Joost, Rodrigues, Robim M., De Boe, Veerle, Rogiers, Vera, De Kock, Joery, Beirinckx, Filip, Vanhaecke, Tamara
Format:	Artikel
Sprache:	eng
Schlagworte:	de novo lipogenesis Drug discovery Drug targets High throughput functional lipid assay Human-based alternative methods MASLD
Online-Zugang:	Volltext
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