Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune‐checkpoint inhibitor‐related biomarkers

Background Advanced penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with limited success of immune‐checkpoint inhibitors (ICIs). Approximately half of pSCC cases are associated with human papillomavirus (HPV) infection. Methods Evaluation was done retrospectively of the lan...

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Veröffentlicht in:	Cancer 2023-12, Vol.129 (24), p.3884-3893
Hauptverfasser:	Nazha, Bassel, Zhuang, Tony, Wu, Sharon, Brown, Jacqueline T., Magee, Daniel, Carthon, Bradley C., Kucuk, Omer, Nabhan, Chadi, Barata, Pedro C., Heath, Elisabeth I., Ryan, Charles J., McKay, Rana R., Master, Viraj A., Bilen, Mehmet Asim
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis B7-H1 Antigen - genetics B7-H1 Antigen - metabolism biomarker Biomarkers Biomarkers, Tumor - genetics Cancer Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Clinical trials Datasets DNA sequencing Fibroblast growth factor 3 Genital cancers Genomics Human papillomavirus human papillomavirus (HPV) Human papillomavirus 16 Human papillomavirus 18 Human Papillomavirus Viruses Humans Immune Checkpoint Inhibitors Immunohistochemistry Inhibitors Male Malignancy Microsatellite instability Mismatch repair Mutation next‐generation sequencing p53 Protein Papillomavirus Infections - complications Papillomavirus Infections - genetics PD-L1 protein penile cancer Penile Neoplasms - genetics Penis Retrospective Studies Risk factors Squamous cell carcinoma Stability analysis Tumorigenesis Tumors
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