An Observational Prospective Cohort Study of Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection of an Aerosolized, Inhaled Adenovirus Type 5–Vectored Coronavirus Disease 2019 Vaccine Given as a Second Booster Dose in Guangzhou City, China
Abstract Using a prospective, observational cohort study during the post–“dynamic COVID-zero” wave in China, we estimated short-term relative effectiveness against Omicron BA.5 infection of inhaled aerosolized adenovirus type 5–vectored ancestral strain coronavirus disease 2019 (COVID-19) vaccine as...
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| Veröffentlicht in: | The Journal of infectious diseases 2024-01, Vol.229 (1), p.117-121 |
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| creator | Wang, Fu-Zhen Zhang, Chun-Huan Tang, Lin Rodewald, Lance E Wang, Wen Liu, Si-Yu Wang, Wen-Ji Wu, Dan Liu, Qian-Qian Wang, Xiao-Qi Huang, Li-Fang Huang, Ao-Di Bao, Li-Ming Zhang, Zhou-Bin Yin, Zun-Dong |
| description | Abstract
Using a prospective, observational cohort study during the post–“dynamic COVID-zero” wave in China, we estimated short-term relative effectiveness against Omicron BA.5 infection of inhaled aerosolized adenovirus type 5–vectored ancestral strain coronavirus disease 2019 (COVID-19) vaccine as a second booster dose approximately 1 year after homologous boosted primary series of inactivated COVID-19 vaccine compared with no second booster. Participants reported nucleic acid or antigen test results weekly until they tested positive or completed predesignated follow-up. After excluding participants infected |
| doi_str_mv | 10.1093/infdis/jiad338 |
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Using a prospective, observational cohort study during the post–“dynamic COVID-zero” wave in China, we estimated short-term relative effectiveness against Omicron BA.5 infection of inhaled aerosolized adenovirus type 5–vectored ancestral strain coronavirus disease 2019 (COVID-19) vaccine as a second booster dose approximately 1 year after homologous boosted primary series of inactivated COVID-19 vaccine compared with no second booster. Participants reported nucleic acid or antigen test results weekly until they tested positive or completed predesignated follow-up. After excluding participants infected <14 days after study entry, relative effectiveness among the 6576 participants was 61% in 18- to 59-year-olds and 38% in ≥60-year-olds and was sustained for 12 weeks.
In a real-world study during China's large SARS-CoV-2 BA.5 variant epidemic wave, effectiveness against actively monitored infection of an inhaled adenovirus type 5–vectored COVID-19 vaccine was 61% in 18- to 59-year-olds and 38% in ≥60-year-olds and was sustained for 12 weeks.</description><identifier>ISSN: 0022-1899</identifier><identifier>ISSN: 1537-6613</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiad338</identifier><identifier>PMID: 37565805</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adenoviridae - genetics ; China - epidemiology ; COVID-19 - prevention & control ; COVID-19 Vaccines ; Humans ; Prospective Studies ; Vaccine Efficacy</subject><ispartof>The Journal of infectious diseases, 2024-01, Vol.229 (1), p.117-121</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-be1c03ceef655bded9b341bee7fc3efbf3829d0e04051d9e9b6ed893f0b243c33</citedby><cites>FETCH-LOGICAL-c369t-be1c03ceef655bded9b341bee7fc3efbf3829d0e04051d9e9b6ed893f0b243c33</cites><orcidid>0000-0002-8901-5326</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37565805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Fu-Zhen</creatorcontrib><creatorcontrib>Zhang, Chun-Huan</creatorcontrib><creatorcontrib>Tang, Lin</creatorcontrib><creatorcontrib>Rodewald, Lance E</creatorcontrib><creatorcontrib>Wang, Wen</creatorcontrib><creatorcontrib>Liu, Si-Yu</creatorcontrib><creatorcontrib>Wang, Wen-Ji</creatorcontrib><creatorcontrib>Wu, Dan</creatorcontrib><creatorcontrib>Liu, Qian-Qian</creatorcontrib><creatorcontrib>Wang, Xiao-Qi</creatorcontrib><creatorcontrib>Huang, Li-Fang</creatorcontrib><creatorcontrib>Huang, Ao-Di</creatorcontrib><creatorcontrib>Bao, Li-Ming</creatorcontrib><creatorcontrib>Zhang, Zhou-Bin</creatorcontrib><creatorcontrib>Yin, Zun-Dong</creatorcontrib><title>An Observational Prospective Cohort Study of Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection of an Aerosolized, Inhaled Adenovirus Type 5–Vectored Coronavirus Disease 2019 Vaccine Given as a Second Booster Dose in Guangzhou City, China</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Using a prospective, observational cohort study during the post–“dynamic COVID-zero” wave in China, we estimated short-term relative effectiveness against Omicron BA.5 infection of inhaled aerosolized adenovirus type 5–vectored ancestral strain coronavirus disease 2019 (COVID-19) vaccine as a second booster dose approximately 1 year after homologous boosted primary series of inactivated COVID-19 vaccine compared with no second booster. Participants reported nucleic acid or antigen test results weekly until they tested positive or completed predesignated follow-up. After excluding participants infected <14 days after study entry, relative effectiveness among the 6576 participants was 61% in 18- to 59-year-olds and 38% in ≥60-year-olds and was sustained for 12 weeks.
In a real-world study during China's large SARS-CoV-2 BA.5 variant epidemic wave, effectiveness against actively monitored infection of an inhaled adenovirus type 5–vectored COVID-19 vaccine was 61% in 18- to 59-year-olds and 38% in ≥60-year-olds and was sustained for 12 weeks.</description><subject>Adenoviridae - genetics</subject><subject>China - epidemiology</subject><subject>COVID-19 - prevention & control</subject><subject>COVID-19 Vaccines</subject><subject>Humans</subject><subject>Prospective Studies</subject><subject>Vaccine Efficacy</subject><issn>0022-1899</issn><issn>1537-6613</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhgMC0aVwhCOaI5Wa1o6TbHIMaVkqVSqipdfIscddV1k72MlK6Yl36BvyJHjJUnHj5MN8881o_EfRe0pOKCnZqTZKan96r7lkrHgeLWjGlnGeU_YiWhCSJDEtyvIgeu39PSEkZfnyVXTAllmeFSRbPHtXGbhqPbotH7Q1vIOvzvoexaC3CLVdWzfA9TDKCayCWy6ENgjnSs2EQe-huuPa-IDhFh1CJcYB4Rv6Xjs-WDfB9WSks5udz4UZW-1GDwlcmD8Wa3ZqbqDCMNp2-gHlcSiueYcSKonGzh03U4-Q_fr5eBvarAvFf31n2iP3CAmh5dOiq92OwD3wsJ2wRsIna_2ADs5sYLWB1cjN3cPajlDrYTqGeq0NfxO9VLzz-Hb_HkbfP5_f1F_iy6vVRV1dxoLl5RC3SAVhAlHlWdZKlGXLUtoiLpVgqFrFiqSUBElKMipLLNscZVEyRdokZYKxw-jj7O2d_TGiH5qN9gK7jhu0o2-SIiOM0jxLA3oyoyIcyTtUTe_0hrupoaTZRaGZo9DsoxAaPuzdY7tB-YT__fsAHM2AHfv_yX4DxBbG1g</recordid><startdate>20240112</startdate><enddate>20240112</enddate><creator>Wang, Fu-Zhen</creator><creator>Zhang, Chun-Huan</creator><creator>Tang, Lin</creator><creator>Rodewald, Lance E</creator><creator>Wang, Wen</creator><creator>Liu, Si-Yu</creator><creator>Wang, Wen-Ji</creator><creator>Wu, Dan</creator><creator>Liu, Qian-Qian</creator><creator>Wang, Xiao-Qi</creator><creator>Huang, Li-Fang</creator><creator>Huang, Ao-Di</creator><creator>Bao, Li-Ming</creator><creator>Zhang, Zhou-Bin</creator><creator>Yin, Zun-Dong</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8901-5326</orcidid></search><sort><creationdate>20240112</creationdate><title>An Observational Prospective Cohort Study of Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection of an Aerosolized, Inhaled Adenovirus Type 5–Vectored Coronavirus Disease 2019 Vaccine Given as a Second Booster Dose in Guangzhou City, China</title><author>Wang, Fu-Zhen ; Zhang, Chun-Huan ; Tang, Lin ; Rodewald, Lance E ; Wang, Wen ; Liu, Si-Yu ; Wang, Wen-Ji ; Wu, Dan ; Liu, Qian-Qian ; Wang, Xiao-Qi ; Huang, Li-Fang ; Huang, Ao-Di ; Bao, Li-Ming ; Zhang, Zhou-Bin ; Yin, Zun-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-be1c03ceef655bded9b341bee7fc3efbf3829d0e04051d9e9b6ed893f0b243c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenoviridae - genetics</topic><topic>China - epidemiology</topic><topic>COVID-19 - prevention & control</topic><topic>COVID-19 Vaccines</topic><topic>Humans</topic><topic>Prospective Studies</topic><topic>Vaccine Efficacy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Fu-Zhen</creatorcontrib><creatorcontrib>Zhang, Chun-Huan</creatorcontrib><creatorcontrib>Tang, Lin</creatorcontrib><creatorcontrib>Rodewald, Lance E</creatorcontrib><creatorcontrib>Wang, Wen</creatorcontrib><creatorcontrib>Liu, Si-Yu</creatorcontrib><creatorcontrib>Wang, Wen-Ji</creatorcontrib><creatorcontrib>Wu, Dan</creatorcontrib><creatorcontrib>Liu, Qian-Qian</creatorcontrib><creatorcontrib>Wang, Xiao-Qi</creatorcontrib><creatorcontrib>Huang, Li-Fang</creatorcontrib><creatorcontrib>Huang, Ao-Di</creatorcontrib><creatorcontrib>Bao, Li-Ming</creatorcontrib><creatorcontrib>Zhang, Zhou-Bin</creatorcontrib><creatorcontrib>Yin, Zun-Dong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Fu-Zhen</au><au>Zhang, Chun-Huan</au><au>Tang, Lin</au><au>Rodewald, Lance E</au><au>Wang, Wen</au><au>Liu, Si-Yu</au><au>Wang, Wen-Ji</au><au>Wu, Dan</au><au>Liu, Qian-Qian</au><au>Wang, Xiao-Qi</au><au>Huang, Li-Fang</au><au>Huang, Ao-Di</au><au>Bao, Li-Ming</au><au>Zhang, Zhou-Bin</au><au>Yin, Zun-Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Observational Prospective Cohort Study of Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection of an Aerosolized, Inhaled Adenovirus Type 5–Vectored Coronavirus Disease 2019 Vaccine Given as a Second Booster Dose in Guangzhou City, China</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2024-01-12</date><risdate>2024</risdate><volume>229</volume><issue>1</issue><spage>117</spage><epage>121</epage><pages>117-121</pages><issn>0022-1899</issn><issn>1537-6613</issn><eissn>1537-6613</eissn><abstract>Abstract
Using a prospective, observational cohort study during the post–“dynamic COVID-zero” wave in China, we estimated short-term relative effectiveness against Omicron BA.5 infection of inhaled aerosolized adenovirus type 5–vectored ancestral strain coronavirus disease 2019 (COVID-19) vaccine as a second booster dose approximately 1 year after homologous boosted primary series of inactivated COVID-19 vaccine compared with no second booster. Participants reported nucleic acid or antigen test results weekly until they tested positive or completed predesignated follow-up. After excluding participants infected <14 days after study entry, relative effectiveness among the 6576 participants was 61% in 18- to 59-year-olds and 38% in ≥60-year-olds and was sustained for 12 weeks.
In a real-world study during China's large SARS-CoV-2 BA.5 variant epidemic wave, effectiveness against actively monitored infection of an inhaled adenovirus type 5–vectored COVID-19 vaccine was 61% in 18- to 59-year-olds and 38% in ≥60-year-olds and was sustained for 12 weeks.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>37565805</pmid><doi>10.1093/infdis/jiad338</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8901-5326</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adenoviridae - genetics China - epidemiology COVID-19 - prevention & control COVID-19 Vaccines Humans Prospective Studies Vaccine Efficacy |
| title | An Observational Prospective Cohort Study of Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection of an Aerosolized, Inhaled Adenovirus Type 5–Vectored Coronavirus Disease 2019 Vaccine Given as a Second Booster Dose in Guangzhou City, China |
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