Safety, Tolerability, and Pharmacokinetics of Valemetostat Tablets and the Effect of Food on Valemetostat Pharmacokinetics in Healthy Subjects: Two Phase 1 Studies

Valemetostat is an oral, selective inhibitor of enhancer of zeste homolog‐2 (EZH2) and EZH1. In a first‐in‐human phase‐1 trial, valemetostat capsules were well tolerated and clinically active in patients with relapsed/refractory non‐Hodgkin lymphoma. Subsequently, a film‐coated tablet formulation wa...

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Veröffentlicht in:	Clinical pharmacology in drug development 2024-01, Vol.13 (1), p.77-86
Hauptverfasser:	Tachibana, Masaya, Matsuki, Shunji, Toyama, Kaoru, Maekawa, Yutaro, Fukae, Masato, Shimizu, Takako, Tsutsumi, Junko, Shinohara, Sayaka, Ishizuka, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	bioavailability Biological Availability Clinical trials clinical trials (CTR) Cross-Over Studies Enzyme Inhibitors Fasting food effect Healthy Volunteers Humans Pharmacokinetics pharmacokinetics and drug metabolism Tablets valemetostat
Online-Zugang:	Volltext
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