Agrocybe cylindracea fucoglucogalactan induced lysosome-mediated apoptosis of colorectal cancer cell through H3K27ac-regulated cathepsin D

Inducing lysosomal dysfunction is emerging as a promising means for cancer therapy. Agrocybe cylindracea fucoglucogalactan (ACP) is a bioactive ingredient with anti-tumor activity, while its mechanism remains obscure. Herein, we found that ACP visibly inhibited the proliferation of colorectal cancer...

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Veröffentlicht in:	Carbohydrate polymers 2023-11, Vol.319, p.121208-121208, Article 121208
Hauptverfasser:	Wang, Ziwei, Chen, Kunying, Zhang, Ke, He, Kaihong, Zhang, Duoduo, Guo, Xiaohan, Huang, Tongwen, Hu, Jielun, Zhou, Xingtao, Nie, Shaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Agrocybe cylindracea fucoglucogalactan Apoptosis Colorectal cancer CTSD H3K27ac Lysosome
Online-Zugang:	Volltext
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