Melatonin promotes orofacial antinociception in adult zebrafish by modulating TRP channels

•Melatonin (MT) promotes orofacial antinociception in adult zebrafish.•MT reduced nociceptive behavior induced by capsaicin (TRPV1 agonist), cinnamaldehyde (TRPA1 agonist) or menthol (TRPM8 agonist).•MT appears to have more affinity for the TRPV1 channel. Melatonin is an endogenous hormone, known as...

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Veröffentlicht in:	Physiology & behavior 2023-10, Vol.269, p.114238-114238, Article 114238
Hauptverfasser:	Sampaio, Guilherme Marinho Moreira Silva, Vieira-Neto, Antônio Eufrásio, Leite, Gerlânia de Oliveira, Campos, Adriana Rolim
Format:	Artikel
Sprache:	eng
Schlagworte:	adults agonists analgesic effect Analgesics - pharmacology Analgesics - therapeutic use Animals antagonists Antinociception behavior capsaicin Capsaicin - pharmacology Danio rerio locomotion Melatonin Melatonin - pharmacology menthol Molecular Docking Simulation nociception sleep transient receptor potential vanilloid channels TRPA1 Cation Channel TRPM Cation Channels TRPs TRPV Cation Channels Zebrafish
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