Nordihydroguaiaretic acid inhibits glyoxalase I, and causes the accumulation of methylglyoxal followed by cell-growth inhibition

Background Methylglyoxal (MGO) is a known toxic byproduct of glycolysis, with MGO-induced cytotoxicity believed to contribute to the pathogenesis of several diseases. Glyoxalase I (GLO1) is a key enzyme for eliminating MGO in mammalian cells, therefore, compounds affecting GLO1 activity are potentia...

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Veröffentlicht in:	Molecular biology reports 2022-11, Vol.49 (11), p.10499-10507
Hauptverfasser:	Watanabe, Masahiro, Toyomura, Takao, Ikegami, Ryo, Suwaki, Yui, Sada, Minami, Wake, Hidenori, Nishinaka, Takashi, Hatipoglu, Omer Faruk, Takahashi, Hideo, Nishibori, Masahiro, Mori, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Advanced glycosylation end products Animal Anatomy Animal Biochemistry Biomedical and Life Sciences By products byproducts cell growth Chemical industry Cytotoxicity Diabetes dose response Enzymatic activity enzyme activity Enzymes Glycolysis Glycosylation growth retardation Histology Intracellular Lactoylglutathione lyase Life Sciences Mammalian cells mammals Metabolism Metabolites Molecular biology Morphology myricetin Nordihydroguaiaretic acid Original Article Oxidative stress Pathogenesis Pharmacology Pyruvaldehyde Statistical analysis therapeutics Toxicity
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