HAPLN3 inhibits apoptosis and promotes EMT of clear cell renal cell carcinoma via ERK and Bcl-2 signal pathways

Hyaluronan and proteoglycan link protein 3 (HAPLN3) is a member of the hyaluronan and proteoglycan link protein family expressed in the extracellular matrix closely associated with the development and occurrence of various malignant tumors; yet, its function in clear cell renal cell cancer (ccRCC) i...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2023, Vol.149 (1), p.79-90
Hauptverfasser:	Ding, Yi, Xiong, Shida, Chen, Xinpeng, Pan, Qiufeng, Fan, Jiawen, Guo, Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Bcl-2 protein Bioinformatics biomarkers Cancer Research Carcinoma, Renal Cell - pathology Cell proliferation Clear cell-type renal cell carcinoma data collection Extracellular matrix Extracellular signal-regulated kinase family genes Genomes Hematology Humans Hyaluronic Acid Internal Medicine Kidney cancer Kidney Neoplasms - pathology Medicine Medicine & Public Health Metastases metastasis Oncology Proteins Proteoglycans renal cell carcinoma Renal function Signal transduction Signal Transduction - genetics Therapeutic targets therapeutics
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