Differential Correlations Informed Metabolite Set Enrichment Analysis to Decipher Metabolic Heterogeneity of Disease

Metabolic pathways are regarded as functional and basic components of the biological system. In metabolomics, metabolite set enrichment analysis (MSEA) is often used to identify the altered metabolic pathways (metabolite sets) associated with phenotypes of interest (POI), e.g., disease. However, in...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-08, Vol.95 (33), p.12505-12513
Hauptverfasser:	Lin, Genjin, Dong, Liheng, Cheng, Kian-Kai, Xu, Xiangnan, Wang, Yongpei, Deng, Lingli, Raftery, Daniel, Dong, Jiyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analytical chemistry Cancer Clustering Colorectal cancer Colorectal carcinoma Correlation Heterogeneity Metabolic pathways Metabolism Metabolites Metabolomics Perturbation Phenotypes Random walk
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