The relationship of immunohistochemical SOX-2 staining with histopathological diagnosis in patients with abnormal colposcopic findings
This study aimed to analyze immunohistochemical staining and pathological data in cervical intraepithelial neoplasia (CIN) and squamous cell cervical carcinoma (SCC) with abnormal colposcopic findings. A histopathological evaluation of 45 low-grade squamous lesions (LSILs), 177 high-grade squamous l...
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| Veröffentlicht in: | Histochemistry and cell biology 2023-12, Vol.160 (6), p.555-561 |
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| creator | Atıgan, Ayhan Kılıç, Derya Karakaya, Yeliz Arman Gök, Soner Güler, Ömer Tolga |
| description | This study aimed to analyze immunohistochemical staining and pathological data in cervical intraepithelial neoplasia (CIN) and squamous cell cervical carcinoma (SCC) with abnormal colposcopic findings. A histopathological evaluation of 45 low-grade squamous lesions (LSILs), 177 high-grade squamous lesions (HSILs) and 16 SCC biopsy materials from existing slides was obtained from blocks obtained from the archive. In addition, SOX-2 immunohistochemical staining was evaluated. The mean age of the HSIL group was 43.20 ± 8.97 years, younger than the mean age of the LSIL group of 51.62 ± 9.64 years (
p
= 0.000). There was no difference between the groups regarding the method of biopsy (
p
> 0.05). Endocervical gland involvement was not observed in the LSIL group, but was observed in 66 (37.3%) biopsy materials in the HSIL group (
p
= 0.000). There was a difference between the groups in terms of the level of CIN at the surgical margin (
p
= 0.000). Ki-67, SOX-2 staining percentage and p16INK4a positivity were higher in the HSIL group than in the LSIL group (respectively, 67.57 ± 19.10 vs. 14.62 ± 7.11,
p
= 0.000; 27.72 ± 31.56 vs. 10.09 ± 15.38,
p
= 0.003; 66 (82.5%) vs. 8 (44.4%),
p
= 0.001). While there was no difference in SOX-2 intensity between the HSIL and LSIL groups (
p
> 0.05), it was statistically significantly higher in the SCC group (
p
= 0.000), as was the percentage of SOX-2 (
p
= 0.000). We have shown that p16INK4a and SOX-2 staining is useful, in addition to Ki-67 immunostaining, which is widely used for SCC, which is one of the preventable cancer types. In addition, SOX-2 may provide a glimmer of hope in the development of SCC treatment modalities, especially since it is aggressively elevated in SCC rather than CIN lesions. |
| doi_str_mv | 10.1007/s00418-023-02230-4 |
| format | Article |
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p
= 0.000). There was no difference between the groups regarding the method of biopsy (
p
> 0.05). Endocervical gland involvement was not observed in the LSIL group, but was observed in 66 (37.3%) biopsy materials in the HSIL group (
p
= 0.000). There was a difference between the groups in terms of the level of CIN at the surgical margin (
p
= 0.000). Ki-67, SOX-2 staining percentage and p16INK4a positivity were higher in the HSIL group than in the LSIL group (respectively, 67.57 ± 19.10 vs. 14.62 ± 7.11,
p
= 0.000; 27.72 ± 31.56 vs. 10.09 ± 15.38,
p
= 0.003; 66 (82.5%) vs. 8 (44.4%),
p
= 0.001). While there was no difference in SOX-2 intensity between the HSIL and LSIL groups (
p
> 0.05), it was statistically significantly higher in the SCC group (
p
= 0.000), as was the percentage of SOX-2 (
p
= 0.000). We have shown that p16INK4a and SOX-2 staining is useful, in addition to Ki-67 immunostaining, which is widely used for SCC, which is one of the preventable cancer types. In addition, SOX-2 may provide a glimmer of hope in the development of SCC treatment modalities, especially since it is aggressively elevated in SCC rather than CIN lesions.</description><identifier>ISSN: 0948-6143</identifier><identifier>EISSN: 1432-119X</identifier><identifier>DOI: 10.1007/s00418-023-02230-4</identifier><identifier>PMID: 37558931</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Biopsy ; Carcinoma, Squamous Cell - pathology ; Cell Biology ; Cervical cancer ; Cervical carcinoma ; Colonoscopy ; Developmental Biology ; Female ; Humans ; Immunohistochemistry ; INK4a protein ; Ki-67 Antigen ; Lesions ; Medical diagnosis ; Middle Aged ; Original Paper ; p16 Protein ; Squamous cell carcinoma ; Staining and Labeling ; Uterine Cervical Dysplasia - diagnosis ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - metabolism ; Vaginal Smears - methods</subject><ispartof>Histochemistry and cell biology, 2023-12, Vol.160 (6), p.555-561</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-4f5fb25efe4c45c8afda5d8a895d3454fb5bfa1e3c8e4bd6c1b7a3f30a7fd5453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00418-023-02230-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00418-023-02230-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37558931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atıgan, Ayhan</creatorcontrib><creatorcontrib>Kılıç, Derya</creatorcontrib><creatorcontrib>Karakaya, Yeliz Arman</creatorcontrib><creatorcontrib>Gök, Soner</creatorcontrib><creatorcontrib>Güler, Ömer Tolga</creatorcontrib><title>The relationship of immunohistochemical SOX-2 staining with histopathological diagnosis in patients with abnormal colposcopic findings</title><title>Histochemistry and cell biology</title><addtitle>Histochem Cell Biol</addtitle><addtitle>Histochem Cell Biol</addtitle><description>This study aimed to analyze immunohistochemical staining and pathological data in cervical intraepithelial neoplasia (CIN) and squamous cell cervical carcinoma (SCC) with abnormal colposcopic findings. A histopathological evaluation of 45 low-grade squamous lesions (LSILs), 177 high-grade squamous lesions (HSILs) and 16 SCC biopsy materials from existing slides was obtained from blocks obtained from the archive. In addition, SOX-2 immunohistochemical staining was evaluated. The mean age of the HSIL group was 43.20 ± 8.97 years, younger than the mean age of the LSIL group of 51.62 ± 9.64 years (
p
= 0.000). There was no difference between the groups regarding the method of biopsy (
p
> 0.05). Endocervical gland involvement was not observed in the LSIL group, but was observed in 66 (37.3%) biopsy materials in the HSIL group (
p
= 0.000). There was a difference between the groups in terms of the level of CIN at the surgical margin (
p
= 0.000). Ki-67, SOX-2 staining percentage and p16INK4a positivity were higher in the HSIL group than in the LSIL group (respectively, 67.57 ± 19.10 vs. 14.62 ± 7.11,
p
= 0.000; 27.72 ± 31.56 vs. 10.09 ± 15.38,
p
= 0.003; 66 (82.5%) vs. 8 (44.4%),
p
= 0.001). While there was no difference in SOX-2 intensity between the HSIL and LSIL groups (
p
> 0.05), it was statistically significantly higher in the SCC group (
p
= 0.000), as was the percentage of SOX-2 (
p
= 0.000). We have shown that p16INK4a and SOX-2 staining is useful, in addition to Ki-67 immunostaining, which is widely used for SCC, which is one of the preventable cancer types. In addition, SOX-2 may provide a glimmer of hope in the development of SCC treatment modalities, especially since it is aggressively elevated in SCC rather than CIN lesions.</description><subject>Adult</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biopsy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Biology</subject><subject>Cervical cancer</subject><subject>Cervical carcinoma</subject><subject>Colonoscopy</subject><subject>Developmental Biology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>INK4a protein</subject><subject>Ki-67 Antigen</subject><subject>Lesions</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>p16 Protein</subject><subject>Squamous cell carcinoma</subject><subject>Staining and Labeling</subject><subject>Uterine Cervical Dysplasia - diagnosis</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Vaginal Smears - methods</subject><issn>0948-6143</issn><issn>1432-119X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90ctq3DAUBmBRGprJtC-QRRF0040bXcfyMoT0AoEskkJ2QpalsYItuTo2IS_Q564yTlPIogsh0Pn0S_AjdErJF0pIfQaECKoqwnhZjJNKvEEbKjirKG3u3qINaYSqduXkGJ0A3BNCZcPYO3TMaylVw-kG_b7tHc5uMHNIEfow4eRxGMclpj7AnGzvxmDNgG-u7yqGYTYhhrjHD2Hu8UFMZu7TkPYH1QWzjwkC4BBxmQQXZ1ixaWPKYzE2DVMCm6ZgsQ-xK3HwHh15M4D78Lxv0c-vl7cX36ur628_Ls6vKsvZbq6El75l0nknrJBWGd8Z2SmjGtlxIYVvZesNddwqJ9puZ2lbG-45MbXvpJB8iz6vuVNOvxYHsx4DWDcMJrq0gGZKKCUE53Whn17R-7TkWH5XVKNqVlNKi2KrsjkBZOf1lMNo8qOmRD-1pNeWdGlJH1rSolz6-By9tKPrXq78raUAvgIoo7h3-d_b_4n9A8LNoTc</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Atıgan, Ayhan</creator><creator>Kılıç, Derya</creator><creator>Karakaya, Yeliz Arman</creator><creator>Gök, Soner</creator><creator>Güler, Ömer Tolga</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20231201</creationdate><title>The relationship of immunohistochemical SOX-2 staining with histopathological diagnosis in patients with abnormal colposcopic findings</title><author>Atıgan, Ayhan ; Kılıç, Derya ; Karakaya, Yeliz Arman ; Gök, Soner ; Güler, Ömer Tolga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-4f5fb25efe4c45c8afda5d8a895d3454fb5bfa1e3c8e4bd6c1b7a3f30a7fd5453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biopsy</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Biology</topic><topic>Cervical cancer</topic><topic>Cervical carcinoma</topic><topic>Colonoscopy</topic><topic>Developmental Biology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>INK4a protein</topic><topic>Ki-67 Antigen</topic><topic>Lesions</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>p16 Protein</topic><topic>Squamous cell carcinoma</topic><topic>Staining and Labeling</topic><topic>Uterine Cervical Dysplasia - diagnosis</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Vaginal Smears - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atıgan, Ayhan</creatorcontrib><creatorcontrib>Kılıç, Derya</creatorcontrib><creatorcontrib>Karakaya, Yeliz Arman</creatorcontrib><creatorcontrib>Gök, Soner</creatorcontrib><creatorcontrib>Güler, Ömer Tolga</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Histochemistry and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atıgan, Ayhan</au><au>Kılıç, Derya</au><au>Karakaya, Yeliz Arman</au><au>Gök, Soner</au><au>Güler, Ömer Tolga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship of immunohistochemical SOX-2 staining with histopathological diagnosis in patients with abnormal colposcopic findings</atitle><jtitle>Histochemistry and cell biology</jtitle><stitle>Histochem Cell Biol</stitle><addtitle>Histochem Cell Biol</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>160</volume><issue>6</issue><spage>555</spage><epage>561</epage><pages>555-561</pages><issn>0948-6143</issn><eissn>1432-119X</eissn><abstract>This study aimed to analyze immunohistochemical staining and pathological data in cervical intraepithelial neoplasia (CIN) and squamous cell cervical carcinoma (SCC) with abnormal colposcopic findings. A histopathological evaluation of 45 low-grade squamous lesions (LSILs), 177 high-grade squamous lesions (HSILs) and 16 SCC biopsy materials from existing slides was obtained from blocks obtained from the archive. In addition, SOX-2 immunohistochemical staining was evaluated. The mean age of the HSIL group was 43.20 ± 8.97 years, younger than the mean age of the LSIL group of 51.62 ± 9.64 years (
p
= 0.000). There was no difference between the groups regarding the method of biopsy (
p
> 0.05). Endocervical gland involvement was not observed in the LSIL group, but was observed in 66 (37.3%) biopsy materials in the HSIL group (
p
= 0.000). There was a difference between the groups in terms of the level of CIN at the surgical margin (
p
= 0.000). Ki-67, SOX-2 staining percentage and p16INK4a positivity were higher in the HSIL group than in the LSIL group (respectively, 67.57 ± 19.10 vs. 14.62 ± 7.11,
p
= 0.000; 27.72 ± 31.56 vs. 10.09 ± 15.38,
p
= 0.003; 66 (82.5%) vs. 8 (44.4%),
p
= 0.001). While there was no difference in SOX-2 intensity between the HSIL and LSIL groups (
p
> 0.05), it was statistically significantly higher in the SCC group (
p
= 0.000), as was the percentage of SOX-2 (
p
= 0.000). We have shown that p16INK4a and SOX-2 staining is useful, in addition to Ki-67 immunostaining, which is widely used for SCC, which is one of the preventable cancer types. In addition, SOX-2 may provide a glimmer of hope in the development of SCC treatment modalities, especially since it is aggressively elevated in SCC rather than CIN lesions.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37558931</pmid><doi>10.1007/s00418-023-02230-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biochemistry Biomarkers Biomedical and Life Sciences Biomedicine Biopsy Carcinoma, Squamous Cell - pathology Cell Biology Cervical cancer Cervical carcinoma Colonoscopy Developmental Biology Female Humans Immunohistochemistry INK4a protein Ki-67 Antigen Lesions Medical diagnosis Middle Aged Original Paper p16 Protein Squamous cell carcinoma Staining and Labeling Uterine Cervical Dysplasia - diagnosis Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - metabolism Vaginal Smears - methods |
| title | The relationship of immunohistochemical SOX-2 staining with histopathological diagnosis in patients with abnormal colposcopic findings |
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