Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures
Abstract Context Climate change and global warming have been hypothesized to influence the increased prevalence of obesity worldwide. However, the evidence is scarce. Objective We aimed to investigate how outside temperature might affect adipose tissue physiology and metabolic traits. Methods The ex...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2024-01, Vol.109 (1), p.e145-e154 |
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| creator | Oliveras-Cañellas, Núria Moreno-Navarrete, José María Lorenzo, Paula M Garrido-Sánchez, Lourdes Becerril, Sara Rangel, Oriol Latorre, Jèssica de la Calle Vargas, Elena Pardo, Maria Valentí, Victor Romero-Cabrera, Juan L Oliva-Olivera, Wilfredo Silva, Camilo Diéguez, Carlos Villarroya, Francesc López, Miguel Crujeiras, Ana B Seoane, Luisa-Maria López-Miranda, José Frühbeck, Gema Tinahones, Francisco José Fernández-Real, José-Manuel |
| description | Abstract
Context
Climate change and global warming have been hypothesized to influence the increased prevalence of obesity worldwide. However, the evidence is scarce.
Objective
We aimed to investigate how outside temperature might affect adipose tissue physiology and metabolic traits.
Methods
The expression of genes involved in thermogenesis/browning and adipogenesis were evaluated (through quantitative polymerase chain reaction) in the subcutaneous adipose tissue (SAT) from 1083 individuals recruited in 5 different regions of Spain (3 in the North and 2 in the South). Plasma biochemical variables and adiponectin (enzyme-linked immunosorbent assay) were collected through standardized protocols. Mean environmental outdoor temperatures were obtained from the National Agency of Meteorology. Univariate, multivariate, and artificial intelligence analyses (Boruta algorithm) were performed.
Results
The SAT expression of genes associated with browning (UCP1, PRDM16, and CIDEA) and ADIPOQ were significantly and negatively associated with minimum, average, and maximum temperatures. The latter temperatures were also negatively associated with the expression of genes involved in adipogenesis (FASN, SLC2A4, and PLIN1). Decreased SAT expression of UCP1 and ADIPOQ messenger RNA and circulating adiponectin were observed with increasing temperatures in all individuals as a whole and within participants with obesity in univariate, multivariate, and artificial intelligence analyses. The differences remained statistically significant in individuals without type 2 diabetes and in samples collected during winter.
Conclusion
Decreased adipose tissue expression of genes involved in browning and adiponectin with increased environmental temperatures were observed. Given the North-South gradient of obesity prevalence in these same regions, the present observations could have implications for the relationship of the obesity pandemic with global warming. |
| doi_str_mv | 10.1210/clinem/dgad469 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2848842013</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A779501118</galeid><oup_id>10.1210/clinem/dgad469</oup_id><sourcerecordid>A779501118</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-8e861752645f44656b3767ce7c2e9bc401b02be8c8819a6758d67f3316ee352f3</originalsourceid><addsrcrecordid>eNqF0UuLFDEUBeAgitOObl1KwI0uaibvx7JnbMeBATctugup1K02UpWUSZWPf28N3boakCwuhO9cLhyEXlJyQRkll2GICcbL7uA7oewjtKFWyEZTqx-jDSGMNlazL2foWa3fCKFCSP4UnXEtFbFWb1B4l3-mAodl8DN0eNvFKVfA-1jrAnj3aypQa8wJ5x5fldXGdMA3kKDiz3H-im9TKODrGt2lH7HkNEKa_YD3ME5Q_Lys-efoSe-HCi9O8xx9er_bX39o7j7e3F5v75oguJobA0ZRLZkSshdCSdVyrXQAHRjYNghCW8JaMMEYar3S0nRK95xTBcAl6_k5enPcO5X8fYE6uzHWAMPgE-SlOmaEMYIRylf6-kgPfgAXU5_n4sM9d1utrSSUUrOqiwfU-joYY8gJ-rj-PxQIJddaoHdTiaMvvx0l7r4vd-zLnfpaA69OJy_tCN0__regFbw9grxM_1v2B8lWoKo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2848842013</pqid></control><display><type>article</type><title>Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures</title><source>Oxford University Press Journals Current</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Oliveras-Cañellas, Núria ; Moreno-Navarrete, José María ; Lorenzo, Paula M ; Garrido-Sánchez, Lourdes ; Becerril, Sara ; Rangel, Oriol ; Latorre, Jèssica ; de la Calle Vargas, Elena ; Pardo, Maria ; Valentí, Victor ; Romero-Cabrera, Juan L ; Oliva-Olivera, Wilfredo ; Silva, Camilo ; Diéguez, Carlos ; Villarroya, Francesc ; López, Miguel ; Crujeiras, Ana B ; Seoane, Luisa-Maria ; López-Miranda, José ; Frühbeck, Gema ; Tinahones, Francisco José ; Fernández-Real, José-Manuel</creator><creatorcontrib>Oliveras-Cañellas, Núria ; Moreno-Navarrete, José María ; Lorenzo, Paula M ; Garrido-Sánchez, Lourdes ; Becerril, Sara ; Rangel, Oriol ; Latorre, Jèssica ; de la Calle Vargas, Elena ; Pardo, Maria ; Valentí, Victor ; Romero-Cabrera, Juan L ; Oliva-Olivera, Wilfredo ; Silva, Camilo ; Diéguez, Carlos ; Villarroya, Francesc ; López, Miguel ; Crujeiras, Ana B ; Seoane, Luisa-Maria ; López-Miranda, José ; Frühbeck, Gema ; Tinahones, Francisco José ; Fernández-Real, José-Manuel</creatorcontrib><description>Abstract
Context
Climate change and global warming have been hypothesized to influence the increased prevalence of obesity worldwide. However, the evidence is scarce.
Objective
We aimed to investigate how outside temperature might affect adipose tissue physiology and metabolic traits.
Methods
The expression of genes involved in thermogenesis/browning and adipogenesis were evaluated (through quantitative polymerase chain reaction) in the subcutaneous adipose tissue (SAT) from 1083 individuals recruited in 5 different regions of Spain (3 in the North and 2 in the South). Plasma biochemical variables and adiponectin (enzyme-linked immunosorbent assay) were collected through standardized protocols. Mean environmental outdoor temperatures were obtained from the National Agency of Meteorology. Univariate, multivariate, and artificial intelligence analyses (Boruta algorithm) were performed.
Results
The SAT expression of genes associated with browning (UCP1, PRDM16, and CIDEA) and ADIPOQ were significantly and negatively associated with minimum, average, and maximum temperatures. The latter temperatures were also negatively associated with the expression of genes involved in adipogenesis (FASN, SLC2A4, and PLIN1). Decreased SAT expression of UCP1 and ADIPOQ messenger RNA and circulating adiponectin were observed with increasing temperatures in all individuals as a whole and within participants with obesity in univariate, multivariate, and artificial intelligence analyses. The differences remained statistically significant in individuals without type 2 diabetes and in samples collected during winter.
Conclusion
Decreased adipose tissue expression of genes involved in browning and adiponectin with increased environmental temperatures were observed. Given the North-South gradient of obesity prevalence in these same regions, the present observations could have implications for the relationship of the obesity pandemic with global warming.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgad469</identifier><identifier>PMID: 37560997</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adipose tissues ; Algorithms ; Artificial intelligence ; C-reactive protein ; Enzyme-linked immunosorbent assay ; Enzymes ; Ethylenediaminetetraacetic acid ; Genes ; Global warming ; Low density lipoproteins ; Messenger RNA ; Type 2 diabetes ; Weather</subject><ispartof>The journal of clinical endocrinology and metabolism, 2024-01, Vol.109 (1), p.e145-e154</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2024 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-8e861752645f44656b3767ce7c2e9bc401b02be8c8819a6758d67f3316ee352f3</citedby><cites>FETCH-LOGICAL-c436t-8e861752645f44656b3767ce7c2e9bc401b02be8c8819a6758d67f3316ee352f3</cites><orcidid>0000-0003-1266-9142 ; 0000-0002-7758-3326 ; 0000-0001-6871-4403 ; 0000-0002-7442-9323</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37560997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveras-Cañellas, Núria</creatorcontrib><creatorcontrib>Moreno-Navarrete, José María</creatorcontrib><creatorcontrib>Lorenzo, Paula M</creatorcontrib><creatorcontrib>Garrido-Sánchez, Lourdes</creatorcontrib><creatorcontrib>Becerril, Sara</creatorcontrib><creatorcontrib>Rangel, Oriol</creatorcontrib><creatorcontrib>Latorre, Jèssica</creatorcontrib><creatorcontrib>de la Calle Vargas, Elena</creatorcontrib><creatorcontrib>Pardo, Maria</creatorcontrib><creatorcontrib>Valentí, Victor</creatorcontrib><creatorcontrib>Romero-Cabrera, Juan L</creatorcontrib><creatorcontrib>Oliva-Olivera, Wilfredo</creatorcontrib><creatorcontrib>Silva, Camilo</creatorcontrib><creatorcontrib>Diéguez, Carlos</creatorcontrib><creatorcontrib>Villarroya, Francesc</creatorcontrib><creatorcontrib>López, Miguel</creatorcontrib><creatorcontrib>Crujeiras, Ana B</creatorcontrib><creatorcontrib>Seoane, Luisa-Maria</creatorcontrib><creatorcontrib>López-Miranda, José</creatorcontrib><creatorcontrib>Frühbeck, Gema</creatorcontrib><creatorcontrib>Tinahones, Francisco José</creatorcontrib><creatorcontrib>Fernández-Real, José-Manuel</creatorcontrib><title>Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context
Climate change and global warming have been hypothesized to influence the increased prevalence of obesity worldwide. However, the evidence is scarce.
Objective
We aimed to investigate how outside temperature might affect adipose tissue physiology and metabolic traits.
Methods
The expression of genes involved in thermogenesis/browning and adipogenesis were evaluated (through quantitative polymerase chain reaction) in the subcutaneous adipose tissue (SAT) from 1083 individuals recruited in 5 different regions of Spain (3 in the North and 2 in the South). Plasma biochemical variables and adiponectin (enzyme-linked immunosorbent assay) were collected through standardized protocols. Mean environmental outdoor temperatures were obtained from the National Agency of Meteorology. Univariate, multivariate, and artificial intelligence analyses (Boruta algorithm) were performed.
Results
The SAT expression of genes associated with browning (UCP1, PRDM16, and CIDEA) and ADIPOQ were significantly and negatively associated with minimum, average, and maximum temperatures. The latter temperatures were also negatively associated with the expression of genes involved in adipogenesis (FASN, SLC2A4, and PLIN1). Decreased SAT expression of UCP1 and ADIPOQ messenger RNA and circulating adiponectin were observed with increasing temperatures in all individuals as a whole and within participants with obesity in univariate, multivariate, and artificial intelligence analyses. The differences remained statistically significant in individuals without type 2 diabetes and in samples collected during winter.
Conclusion
Decreased adipose tissue expression of genes involved in browning and adiponectin with increased environmental temperatures were observed. Given the North-South gradient of obesity prevalence in these same regions, the present observations could have implications for the relationship of the obesity pandemic with global warming.</description><subject>Adipose tissues</subject><subject>Algorithms</subject><subject>Artificial intelligence</subject><subject>C-reactive protein</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Genes</subject><subject>Global warming</subject><subject>Low density lipoproteins</subject><subject>Messenger RNA</subject><subject>Type 2 diabetes</subject><subject>Weather</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqF0UuLFDEUBeAgitOObl1KwI0uaibvx7JnbMeBATctugup1K02UpWUSZWPf28N3boakCwuhO9cLhyEXlJyQRkll2GICcbL7uA7oewjtKFWyEZTqx-jDSGMNlazL2foWa3fCKFCSP4UnXEtFbFWb1B4l3-mAodl8DN0eNvFKVfA-1jrAnj3aypQa8wJ5x5fldXGdMA3kKDiz3H-im9TKODrGt2lH7HkNEKa_YD3ME5Q_Lys-efoSe-HCi9O8xx9er_bX39o7j7e3F5v75oguJobA0ZRLZkSshdCSdVyrXQAHRjYNghCW8JaMMEYar3S0nRK95xTBcAl6_k5enPcO5X8fYE6uzHWAMPgE-SlOmaEMYIRylf6-kgPfgAXU5_n4sM9d1utrSSUUrOqiwfU-joYY8gJ-rj-PxQIJddaoHdTiaMvvx0l7r4vd-zLnfpaA69OJy_tCN0__regFbw9grxM_1v2B8lWoKo</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Oliveras-Cañellas, Núria</creator><creator>Moreno-Navarrete, José María</creator><creator>Lorenzo, Paula M</creator><creator>Garrido-Sánchez, Lourdes</creator><creator>Becerril, Sara</creator><creator>Rangel, Oriol</creator><creator>Latorre, Jèssica</creator><creator>de la Calle Vargas, Elena</creator><creator>Pardo, Maria</creator><creator>Valentí, Victor</creator><creator>Romero-Cabrera, Juan L</creator><creator>Oliva-Olivera, Wilfredo</creator><creator>Silva, Camilo</creator><creator>Diéguez, Carlos</creator><creator>Villarroya, Francesc</creator><creator>López, Miguel</creator><creator>Crujeiras, Ana B</creator><creator>Seoane, Luisa-Maria</creator><creator>López-Miranda, José</creator><creator>Frühbeck, Gema</creator><creator>Tinahones, Francisco José</creator><creator>Fernández-Real, José-Manuel</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1266-9142</orcidid><orcidid>https://orcid.org/0000-0002-7758-3326</orcidid><orcidid>https://orcid.org/0000-0001-6871-4403</orcidid><orcidid>https://orcid.org/0000-0002-7442-9323</orcidid></search><sort><creationdate>20240101</creationdate><title>Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures</title><author>Oliveras-Cañellas, Núria ; Moreno-Navarrete, José María ; Lorenzo, Paula M ; Garrido-Sánchez, Lourdes ; Becerril, Sara ; Rangel, Oriol ; Latorre, Jèssica ; de la Calle Vargas, Elena ; Pardo, Maria ; Valentí, Victor ; Romero-Cabrera, Juan L ; Oliva-Olivera, Wilfredo ; Silva, Camilo ; Diéguez, Carlos ; Villarroya, Francesc ; López, Miguel ; Crujeiras, Ana B ; Seoane, Luisa-Maria ; López-Miranda, José ; Frühbeck, Gema ; Tinahones, Francisco José ; Fernández-Real, José-Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-8e861752645f44656b3767ce7c2e9bc401b02be8c8819a6758d67f3316ee352f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adipose tissues</topic><topic>Algorithms</topic><topic>Artificial intelligence</topic><topic>C-reactive protein</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Genes</topic><topic>Global warming</topic><topic>Low density lipoproteins</topic><topic>Messenger RNA</topic><topic>Type 2 diabetes</topic><topic>Weather</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveras-Cañellas, Núria</creatorcontrib><creatorcontrib>Moreno-Navarrete, José María</creatorcontrib><creatorcontrib>Lorenzo, Paula M</creatorcontrib><creatorcontrib>Garrido-Sánchez, Lourdes</creatorcontrib><creatorcontrib>Becerril, Sara</creatorcontrib><creatorcontrib>Rangel, Oriol</creatorcontrib><creatorcontrib>Latorre, Jèssica</creatorcontrib><creatorcontrib>de la Calle Vargas, Elena</creatorcontrib><creatorcontrib>Pardo, Maria</creatorcontrib><creatorcontrib>Valentí, Victor</creatorcontrib><creatorcontrib>Romero-Cabrera, Juan L</creatorcontrib><creatorcontrib>Oliva-Olivera, Wilfredo</creatorcontrib><creatorcontrib>Silva, Camilo</creatorcontrib><creatorcontrib>Diéguez, Carlos</creatorcontrib><creatorcontrib>Villarroya, Francesc</creatorcontrib><creatorcontrib>López, Miguel</creatorcontrib><creatorcontrib>Crujeiras, Ana B</creatorcontrib><creatorcontrib>Seoane, Luisa-Maria</creatorcontrib><creatorcontrib>López-Miranda, José</creatorcontrib><creatorcontrib>Frühbeck, Gema</creatorcontrib><creatorcontrib>Tinahones, Francisco José</creatorcontrib><creatorcontrib>Fernández-Real, José-Manuel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveras-Cañellas, Núria</au><au>Moreno-Navarrete, José María</au><au>Lorenzo, Paula M</au><au>Garrido-Sánchez, Lourdes</au><au>Becerril, Sara</au><au>Rangel, Oriol</au><au>Latorre, Jèssica</au><au>de la Calle Vargas, Elena</au><au>Pardo, Maria</au><au>Valentí, Victor</au><au>Romero-Cabrera, Juan L</au><au>Oliva-Olivera, Wilfredo</au><au>Silva, Camilo</au><au>Diéguez, Carlos</au><au>Villarroya, Francesc</au><au>López, Miguel</au><au>Crujeiras, Ana B</au><au>Seoane, Luisa-Maria</au><au>López-Miranda, José</au><au>Frühbeck, Gema</au><au>Tinahones, Francisco José</au><au>Fernández-Real, José-Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>109</volume><issue>1</issue><spage>e145</spage><epage>e154</epage><pages>e145-e154</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context
Climate change and global warming have been hypothesized to influence the increased prevalence of obesity worldwide. However, the evidence is scarce.
Objective
We aimed to investigate how outside temperature might affect adipose tissue physiology and metabolic traits.
Methods
The expression of genes involved in thermogenesis/browning and adipogenesis were evaluated (through quantitative polymerase chain reaction) in the subcutaneous adipose tissue (SAT) from 1083 individuals recruited in 5 different regions of Spain (3 in the North and 2 in the South). Plasma biochemical variables and adiponectin (enzyme-linked immunosorbent assay) were collected through standardized protocols. Mean environmental outdoor temperatures were obtained from the National Agency of Meteorology. Univariate, multivariate, and artificial intelligence analyses (Boruta algorithm) were performed.
Results
The SAT expression of genes associated with browning (UCP1, PRDM16, and CIDEA) and ADIPOQ were significantly and negatively associated with minimum, average, and maximum temperatures. The latter temperatures were also negatively associated with the expression of genes involved in adipogenesis (FASN, SLC2A4, and PLIN1). Decreased SAT expression of UCP1 and ADIPOQ messenger RNA and circulating adiponectin were observed with increasing temperatures in all individuals as a whole and within participants with obesity in univariate, multivariate, and artificial intelligence analyses. The differences remained statistically significant in individuals without type 2 diabetes and in samples collected during winter.
Conclusion
Decreased adipose tissue expression of genes involved in browning and adiponectin with increased environmental temperatures were observed. Given the North-South gradient of obesity prevalence in these same regions, the present observations could have implications for the relationship of the obesity pandemic with global warming.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>37560997</pmid><doi>10.1210/clinem/dgad469</doi><orcidid>https://orcid.org/0000-0003-1266-9142</orcidid><orcidid>https://orcid.org/0000-0002-7758-3326</orcidid><orcidid>https://orcid.org/0000-0001-6871-4403</orcidid><orcidid>https://orcid.org/0000-0002-7442-9323</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2024-01, Vol.109 (1), p.e145-e154 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2848842013 |
| source | Oxford University Press Journals Current; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adipose tissues Algorithms Artificial intelligence C-reactive protein Enzyme-linked immunosorbent assay Enzymes Ethylenediaminetetraacetic acid Genes Global warming Low density lipoproteins Messenger RNA Type 2 diabetes Weather |
| title | Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures |
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