Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice
One-step and two-step pathways are proposed to synthesize cytokinin in plants. The one-step pathway is mediated by LONELY GUY (LOG) proteins. However, the enzyme for the two-step pathway remains to be identified. Here, we show that quantitative trait locus GY3 may boost grain yield by more than 20%...
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| Veröffentlicht in: | Nature genetics 2023-08, Vol.55 (8), p.1381-1389 |
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| creator | Wu, Bi Meng, Jianghu Liu, Hongbo Mao, Donghai Yin, Huanran Zhang, Zhanyi Zhou, Xiangchun Zhang, Bo Sherif, Ahmed Liu, Haiyang Li, Xianghua Xiao, Jinghua Yan, Wenhao Wang, Lei Li, Xingwang Chen, Wei Xie, Weibo Yin, Ping Zhang, Qifa Xing, Yongzhong |
| description | One-step and two-step pathways are proposed to synthesize cytokinin in plants. The one-step pathway is mediated by LONELY GUY (LOG) proteins. However, the enzyme for the two-step pathway remains to be identified. Here, we show that quantitative trait locus
GY3
may boost grain yield by more than 20% through manipulating a two-step pathway. Locus
GY3
encodes a LOG protein that acts as a 5′-ribonucleotide phosphohydrolase by excessively consuming the cytokinin precursors, which contrasts with the activity of canonical LOG members as phosphoribohydrolases in a one-step pathway. The residue S41 of GY3 is crucial for the dephosphorylation of iPRMP to produce iPR. A
solo-LTR
insertion within the promoter of
GY3
suppressed its expression and resulted in a higher content of active cytokinins in young panicles. Introgression of
GY3
02428
increased grain yield per plot by 7.4% to 16.3% in all investigated
indica
backgrounds, which demonstrates the great value of
GY3
02428
in
indica
rice production.
GY3
encodes a LOG-like protein that acts as a 5′-ribonucleotide phosphohydrolase in cytokinin synthesis. A
Gypsy
solo-LTR
insertion downregulates
GY3
expression and shows the potential to enhance grain yield in rice. |
| doi_str_mv | 10.1038/s41588-023-01454-3 |
| format | Article |
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GY3
may boost grain yield by more than 20% through manipulating a two-step pathway. Locus
GY3
encodes a LOG protein that acts as a 5′-ribonucleotide phosphohydrolase by excessively consuming the cytokinin precursors, which contrasts with the activity of canonical LOG members as phosphoribohydrolases in a one-step pathway. The residue S41 of GY3 is crucial for the dephosphorylation of iPRMP to produce iPR. A
solo-LTR
insertion within the promoter of
GY3
suppressed its expression and resulted in a higher content of active cytokinins in young panicles. Introgression of
GY3
02428
increased grain yield per plot by 7.4% to 16.3% in all investigated
indica
backgrounds, which demonstrates the great value of
GY3
02428
in
indica
rice production.
GY3
encodes a LOG-like protein that acts as a 5′-ribonucleotide phosphohydrolase in cytokinin synthesis. A
Gypsy
solo-LTR
insertion downregulates
GY3
expression and shows the potential to enhance grain yield in rice.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/s41588-023-01454-3</identifier><identifier>PMID: 37500729</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>38/1 ; 38/23 ; 631/208/2491 ; 631/208/711 ; Agriculture ; Animal Genetics and Genomics ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Crop production ; Crop yield ; Cytokinins ; Dephosphorylation ; DNA methylation ; Gene Function ; Gene mapping ; Human Genetics ; Leaves ; Nucleotides ; Phosphohydrolase ; Proteins ; Quantitative trait loci ; Rice</subject><ispartof>Nature genetics, 2023-08, Vol.55 (8), p.1381-1389</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><rights>Copyright Nature Publishing Group Aug 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-bc76b2303a5896d1aca7c7403bf9f6cedb9b865ff9146939a5fa11200e53bdff3</citedby><cites>FETCH-LOGICAL-c375t-bc76b2303a5896d1aca7c7403bf9f6cedb9b865ff9146939a5fa11200e53bdff3</cites><orcidid>0000-0001-8001-221X ; 0000-0002-1151-1848 ; 0000-0003-3985-2545 ; 0000-0003-2693-2685 ; 0000-0002-2768-3572 ; 0000-0003-0612-2589 ; 0000-0003-2087-6555 ; 0000-0003-1376-1514</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41588-023-01454-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41588-023-01454-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37500729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Bi</creatorcontrib><creatorcontrib>Meng, Jianghu</creatorcontrib><creatorcontrib>Liu, Hongbo</creatorcontrib><creatorcontrib>Mao, Donghai</creatorcontrib><creatorcontrib>Yin, Huanran</creatorcontrib><creatorcontrib>Zhang, Zhanyi</creatorcontrib><creatorcontrib>Zhou, Xiangchun</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Sherif, Ahmed</creatorcontrib><creatorcontrib>Liu, Haiyang</creatorcontrib><creatorcontrib>Li, Xianghua</creatorcontrib><creatorcontrib>Xiao, Jinghua</creatorcontrib><creatorcontrib>Yan, Wenhao</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Li, Xingwang</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Xie, Weibo</creatorcontrib><creatorcontrib>Yin, Ping</creatorcontrib><creatorcontrib>Zhang, Qifa</creatorcontrib><creatorcontrib>Xing, Yongzhong</creatorcontrib><title>Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>One-step and two-step pathways are proposed to synthesize cytokinin in plants. The one-step pathway is mediated by LONELY GUY (LOG) proteins. However, the enzyme for the two-step pathway remains to be identified. Here, we show that quantitative trait locus
GY3
may boost grain yield by more than 20% through manipulating a two-step pathway. Locus
GY3
encodes a LOG protein that acts as a 5′-ribonucleotide phosphohydrolase by excessively consuming the cytokinin precursors, which contrasts with the activity of canonical LOG members as phosphoribohydrolases in a one-step pathway. The residue S41 of GY3 is crucial for the dephosphorylation of iPRMP to produce iPR. A
solo-LTR
insertion within the promoter of
GY3
suppressed its expression and resulted in a higher content of active cytokinins in young panicles. Introgression of
GY3
02428
increased grain yield per plot by 7.4% to 16.3% in all investigated
indica
backgrounds, which demonstrates the great value of
GY3
02428
in
indica
rice production.
GY3
encodes a LOG-like protein that acts as a 5′-ribonucleotide phosphohydrolase in cytokinin synthesis. A
Gypsy
solo-LTR
insertion downregulates
GY3
expression and shows the potential to enhance grain yield in rice.</description><subject>38/1</subject><subject>38/23</subject><subject>631/208/2491</subject><subject>631/208/711</subject><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Crop production</subject><subject>Crop yield</subject><subject>Cytokinins</subject><subject>Dephosphorylation</subject><subject>DNA methylation</subject><subject>Gene Function</subject><subject>Gene mapping</subject><subject>Human Genetics</subject><subject>Leaves</subject><subject>Nucleotides</subject><subject>Phosphohydrolase</subject><subject>Proteins</subject><subject>Quantitative trait 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a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice</title><author>Wu, Bi ; Meng, Jianghu ; Liu, Hongbo ; Mao, Donghai ; Yin, Huanran ; Zhang, Zhanyi ; Zhou, Xiangchun ; Zhang, Bo ; Sherif, Ahmed ; Liu, Haiyang ; Li, Xianghua ; Xiao, Jinghua ; Yan, Wenhao ; Wang, Lei ; Li, Xingwang ; Chen, Wei ; Xie, Weibo ; Yin, Ping ; Zhang, Qifa ; Xing, Yongzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-bc76b2303a5896d1aca7c7403bf9f6cedb9b865ff9146939a5fa11200e53bdff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>38/1</topic><topic>38/23</topic><topic>631/208/2491</topic><topic>631/208/711</topic><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Crop production</topic><topic>Crop yield</topic><topic>Cytokinins</topic><topic>Dephosphorylation</topic><topic>DNA methylation</topic><topic>Gene Function</topic><topic>Gene mapping</topic><topic>Human Genetics</topic><topic>Leaves</topic><topic>Nucleotides</topic><topic>Phosphohydrolase</topic><topic>Proteins</topic><topic>Quantitative trait loci</topic><topic>Rice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Bi</creatorcontrib><creatorcontrib>Meng, Jianghu</creatorcontrib><creatorcontrib>Liu, Hongbo</creatorcontrib><creatorcontrib>Mao, Donghai</creatorcontrib><creatorcontrib>Yin, Huanran</creatorcontrib><creatorcontrib>Zhang, Zhanyi</creatorcontrib><creatorcontrib>Zhou, Xiangchun</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Sherif, Ahmed</creatorcontrib><creatorcontrib>Liu, Haiyang</creatorcontrib><creatorcontrib>Li, Xianghua</creatorcontrib><creatorcontrib>Xiao, Jinghua</creatorcontrib><creatorcontrib>Yan, 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Yongzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>55</volume><issue>8</issue><spage>1381</spage><epage>1389</epage><pages>1381-1389</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><abstract>One-step and two-step pathways are proposed to synthesize cytokinin in plants. The one-step pathway is mediated by LONELY GUY (LOG) proteins. However, the enzyme for the two-step pathway remains to be identified. Here, we show that quantitative trait locus
GY3
may boost grain yield by more than 20% through manipulating a two-step pathway. Locus
GY3
encodes a LOG protein that acts as a 5′-ribonucleotide phosphohydrolase by excessively consuming the cytokinin precursors, which contrasts with the activity of canonical LOG members as phosphoribohydrolases in a one-step pathway. The residue S41 of GY3 is crucial for the dephosphorylation of iPRMP to produce iPR. A
solo-LTR
insertion within the promoter of
GY3
suppressed its expression and resulted in a higher content of active cytokinins in young panicles. Introgression of
GY3
02428
increased grain yield per plot by 7.4% to 16.3% in all investigated
indica
backgrounds, which demonstrates the great value of
GY3
02428
in
indica
rice production.
GY3
encodes a LOG-like protein that acts as a 5′-ribonucleotide phosphohydrolase in cytokinin synthesis. A
Gypsy
solo-LTR
insertion downregulates
GY3
expression and shows the potential to enhance grain yield in rice.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>37500729</pmid><doi>10.1038/s41588-023-01454-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8001-221X</orcidid><orcidid>https://orcid.org/0000-0002-1151-1848</orcidid><orcidid>https://orcid.org/0000-0003-3985-2545</orcidid><orcidid>https://orcid.org/0000-0003-2693-2685</orcidid><orcidid>https://orcid.org/0000-0002-2768-3572</orcidid><orcidid>https://orcid.org/0000-0003-0612-2589</orcidid><orcidid>https://orcid.org/0000-0003-2087-6555</orcidid><orcidid>https://orcid.org/0000-0003-1376-1514</orcidid></addata></record> |
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| source | Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 38/1 38/23 631/208/2491 631/208/711 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Crop production Crop yield Cytokinins Dephosphorylation DNA methylation Gene Function Gene mapping Human Genetics Leaves Nucleotides Phosphohydrolase Proteins Quantitative trait loci Rice |
| title | Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice |
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