Ascending Aorta 4D Time to Peak Distention Sexual Dimorphism and Association with Coronary Plaque Burden Severity in Women
Coronary artery disease (CAD) risk and plaque scores are often subjective and biased, particularly in mid-age asymptomatic women, whose CAD risk assessment has been historically underestimated. In this study, a new automatic ascending aorta time-to-peak-distention (TPD) analysis was developed for fa...
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| Veröffentlicht in: | Journal of cardiovascular translational research 2024-04, Vol.17 (2), p.298-307 |
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| container_title | Journal of cardiovascular translational research |
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| creator | Hamimi, Ahmed H. Ghanem, Ahmed M. Hannah-Shmouni, Fady Elgarf, Reham M. Matta, Jatin R. Gharib, Ahmed M. Abd-Elmoniem, Khaled Z. |
| description | Coronary artery disease (CAD) risk and plaque scores are often subjective and biased, particularly in mid-age asymptomatic women, whose CAD risk assessment has been historically underestimated. In this study, a new automatic ascending aorta time-to-peak-distention (TPD) analysis was developed for fast screening and as an independent surrogate for subclinical atherosclerosis in asymptomatic women. CCTA was obtained in 50 asymptomatic adults. Plaque burden segment involvement score (SIS) and automatic TPD were obtained from all subjects. Logistic regression analyses were performed to investigate the association between CAD risk scores and TPD with severe coronary plaque burden (SIS>5). TPD, individually, was found to be a significant predictor of SIS>5. Additionally, sex was a significant effect modifier of TPD, with a stronger statistically significant association with women. Four-dimensional aortic time-to-peak distention could supplement conventional CCTA analysis and offer a quick objective screening tool for plaque burden severity and CAD risk stratification, especially in women.
Graphical Abstract |
| doi_str_mv | 10.1007/s12265-023-10422-5 |
| format | Article |
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Graphical Abstract</description><subject>Adult</subject><subject>Aged</subject><subject>Aorta - diagnostic imaging</subject><subject>Aorta - pathology</subject><subject>Aorta - physiopathology</subject><subject>Aortography</subject><subject>Asymptomatic Diseases</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Cardiology</subject><subject>Computed Tomography Angiography</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - physiopathology</subject><subject>Female</subject><subject>Health Status Disparities</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Time Factors</subject><issn>1937-5387</issn><issn>1937-5395</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPxCAUhYnR-P4DLgxLN1UeQ6HLcXwmJpqocUlouVW0hRFaX79edNSlK2643zlwDkI7lOxTQuRBooyVoiCMF5RMGCvEElqnFZeF4JVY_puVXEMbKT0SUjIi5Spa41KIknC5jj6mqQFvnb_H0xAHgydH-Mb1gIeAr8A84SOXBvCDCx5fw9tounzThzh_cKnHxls8TSk0znwTr254wLMQgzfxHV915nkEfDhGC1_qF4hueMfO47vQg99CK63pEmz_nJvo9uT4ZnZWXFyens-mF0XDKjUUzBiomrpSUoEVgtvW1hQsiJqWjFFbKdqUjWlsKRUljAITzArTVorXddsSvon2Fr7zGPJ_0qB7l0N3nfEQxqSZmiiWnypVRtkCbWJIKUKr59H1OYumRH91rhed69y5_u5ciyza_fEf6x7sn-S35AzwBZDyyt9D1I9hjD5n_s_2E5aajiI</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Hamimi, Ahmed H.</creator><creator>Ghanem, Ahmed M.</creator><creator>Hannah-Shmouni, Fady</creator><creator>Elgarf, Reham M.</creator><creator>Matta, Jatin R.</creator><creator>Gharib, Ahmed M.</creator><creator>Abd-Elmoniem, Khaled Z.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1001-1702</orcidid></search><sort><creationdate>20240401</creationdate><title>Ascending Aorta 4D Time to Peak Distention Sexual Dimorphism and Association with Coronary Plaque Burden Severity in Women</title><author>Hamimi, Ahmed H. ; Ghanem, Ahmed M. ; Hannah-Shmouni, Fady ; Elgarf, Reham M. ; Matta, Jatin R. ; Gharib, Ahmed M. ; Abd-Elmoniem, Khaled Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-2aae9cb9878ed553dfdb1ede5b16221d981c6cacd6781021e252d5af983bbff03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aorta - diagnostic imaging</topic><topic>Aorta - pathology</topic><topic>Aorta - physiopathology</topic><topic>Aortography</topic><topic>Asymptomatic Diseases</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Cardiology</topic><topic>Computed Tomography Angiography</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - physiopathology</topic><topic>Female</topic><topic>Health Status Disparities</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Plaque, Atherosclerotic</topic><topic>Predictive Value of Tests</topic><topic>Radiographic Image Interpretation, Computer-Assisted</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamimi, Ahmed H.</creatorcontrib><creatorcontrib>Ghanem, Ahmed M.</creatorcontrib><creatorcontrib>Hannah-Shmouni, Fady</creatorcontrib><creatorcontrib>Elgarf, Reham M.</creatorcontrib><creatorcontrib>Matta, Jatin R.</creatorcontrib><creatorcontrib>Gharib, Ahmed M.</creatorcontrib><creatorcontrib>Abd-Elmoniem, Khaled Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular translational research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamimi, Ahmed H.</au><au>Ghanem, Ahmed M.</au><au>Hannah-Shmouni, Fady</au><au>Elgarf, Reham M.</au><au>Matta, Jatin R.</au><au>Gharib, Ahmed M.</au><au>Abd-Elmoniem, Khaled Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ascending Aorta 4D Time to Peak Distention Sexual Dimorphism and Association with Coronary Plaque Burden Severity in Women</atitle><jtitle>Journal of cardiovascular translational research</jtitle><stitle>J. of Cardiovasc. Trans. Res</stitle><addtitle>J Cardiovasc Transl Res</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>17</volume><issue>2</issue><spage>298</spage><epage>307</epage><pages>298-307</pages><issn>1937-5387</issn><eissn>1937-5395</eissn><abstract>Coronary artery disease (CAD) risk and plaque scores are often subjective and biased, particularly in mid-age asymptomatic women, whose CAD risk assessment has been historically underestimated. In this study, a new automatic ascending aorta time-to-peak-distention (TPD) analysis was developed for fast screening and as an independent surrogate for subclinical atherosclerosis in asymptomatic women. CCTA was obtained in 50 asymptomatic adults. Plaque burden segment involvement score (SIS) and automatic TPD were obtained from all subjects. Logistic regression analyses were performed to investigate the association between CAD risk scores and TPD with severe coronary plaque burden (SIS>5). TPD, individually, was found to be a significant predictor of SIS>5. Additionally, sex was a significant effect modifier of TPD, with a stronger statistically significant association with women. Four-dimensional aortic time-to-peak distention could supplement conventional CCTA analysis and offer a quick objective screening tool for plaque burden severity and CAD risk stratification, especially in women.
Graphical Abstract</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37556037</pmid><doi>10.1007/s12265-023-10422-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1001-1702</orcidid></addata></record> |
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| subjects | Adult Aged Aorta - diagnostic imaging Aorta - pathology Aorta - physiopathology Aortography Asymptomatic Diseases Biomedical Engineering and Bioengineering Biomedicine Cardiology Computed Tomography Angiography Coronary Angiography Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - physiopathology Coronary Vessels - diagnostic imaging Coronary Vessels - physiopathology Female Health Status Disparities Human Genetics Humans Male Medicine Medicine & Public Health Middle Aged Original Article Plaque, Atherosclerotic Predictive Value of Tests Radiographic Image Interpretation, Computer-Assisted Risk Assessment Risk Factors Severity of Illness Index Sex Factors Time Factors |
| title | Ascending Aorta 4D Time to Peak Distention Sexual Dimorphism and Association with Coronary Plaque Burden Severity in Women |
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