Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice
This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. UCBMCs were injected once into the scrotal sheath cavity of elderly mice. The transplanted UCBMCs survived in the scrotal sheath cavity for 1 m...
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| Veröffentlicht in: | Regenerative medicine 2023-09, Vol.18 (9), p.695-706 |
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| container_title | Regenerative medicine |
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| creator | Li, Jun Jiang, Yinghong Xue, Wei Liu, Lejiang Yu, Hua Zhang, Xuemei Ye, Xiao Miao, Jianrong Liu, Jianling Chen, Yueen Lan, Xingbin Liu, Xiaoqing Yao, Wensong Sun, Jianchuan Zheng, Jing Xiao, Jianzhong |
| description | This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice.
UCBMCs were injected once into the scrotal sheath cavity of elderly mice.
The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000).
Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction. |
| doi_str_mv | 10.2217/rme-2022-0191 |
| format | Article |
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UCBMCs were injected once into the scrotal sheath cavity of elderly mice.
The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000).
Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.</description><identifier>ISSN: 1746-0751</identifier><identifier>EISSN: 1746-076X</identifier><identifier>DOI: 10.2217/rme-2022-0191</identifier><identifier>PMID: 37554102</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>elderly ; erectile dysfunction ; mouse ; scrotum ; stem cell ; umbilical cord blood mononuclear cells</subject><ispartof>Regenerative medicine, 2023-09, Vol.18 (9), p.695-706</ispartof><rights>2023 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c299t-c6dcd2786e62d1c5aa8b9124b2035a4076e5d2b7991c522c8acabfacabdc0e0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37554102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Jiang, Yinghong</creatorcontrib><creatorcontrib>Xue, Wei</creatorcontrib><creatorcontrib>Liu, Lejiang</creatorcontrib><creatorcontrib>Yu, Hua</creatorcontrib><creatorcontrib>Zhang, Xuemei</creatorcontrib><creatorcontrib>Ye, Xiao</creatorcontrib><creatorcontrib>Miao, Jianrong</creatorcontrib><creatorcontrib>Liu, Jianling</creatorcontrib><creatorcontrib>Chen, Yueen</creatorcontrib><creatorcontrib>Lan, Xingbin</creatorcontrib><creatorcontrib>Liu, Xiaoqing</creatorcontrib><creatorcontrib>Yao, Wensong</creatorcontrib><creatorcontrib>Sun, Jianchuan</creatorcontrib><creatorcontrib>Zheng, Jing</creatorcontrib><creatorcontrib>Xiao, Jianzhong</creatorcontrib><title>Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice</title><title>Regenerative medicine</title><addtitle>Regen Med</addtitle><description>This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice.
UCBMCs were injected once into the scrotal sheath cavity of elderly mice.
The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000).
Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.</description><subject>elderly</subject><subject>erectile dysfunction</subject><subject>mouse</subject><subject>scrotum</subject><subject>stem cell</subject><subject>umbilical cord blood mononuclear cells</subject><issn>1746-0751</issn><issn>1746-076X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kDtvHSEQRlGUKHbslG4jSjcbw9x9lpHlRyRLaRzJHWKHWQWLhRsekv3vzfo67tIAA2c-MYexMym-A8jhIq7UgABohJzkB3Ysh7ZvxNA_fHw_d_KIfUnpUYhuN3bwmR3thq5rpYBj9nS1LIQ58bDwHLVPe6d91tkGv12VdbbOonYcQzR8diEYvgYffEFHOnIk5xK3Pgee_xBPGEMuK6_diZ5K7VuKx9c06zk5Q9E989UinbJPi3aJvr7tJ-z39dX95W1z9-vm5-WPuwZhmnKDvUEDw9hTD0Zip_U4TxLaGcSu020dlDoD8zBN9REAR416XrbFoCBBuxN2fsjdx_C3UMpqtWn7tfYUSlIwtiNA9TFWtDmgdYiUIi1qH-2q47OSQm2yVZWtNtlqk135b2_RZV7JvNP_7FZgOgBLySVSQkseSR2q2mHRevpP-AudCZF3</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Li, Jun</creator><creator>Jiang, Yinghong</creator><creator>Xue, Wei</creator><creator>Liu, Lejiang</creator><creator>Yu, Hua</creator><creator>Zhang, Xuemei</creator><creator>Ye, Xiao</creator><creator>Miao, Jianrong</creator><creator>Liu, Jianling</creator><creator>Chen, Yueen</creator><creator>Lan, Xingbin</creator><creator>Liu, Xiaoqing</creator><creator>Yao, Wensong</creator><creator>Sun, Jianchuan</creator><creator>Zheng, Jing</creator><creator>Xiao, Jianzhong</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230901</creationdate><title>Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice</title><author>Li, Jun ; Jiang, Yinghong ; Xue, Wei ; Liu, Lejiang ; Yu, Hua ; Zhang, Xuemei ; Ye, Xiao ; Miao, Jianrong ; Liu, Jianling ; Chen, Yueen ; Lan, Xingbin ; Liu, Xiaoqing ; Yao, Wensong ; Sun, Jianchuan ; Zheng, Jing ; Xiao, Jianzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-c6dcd2786e62d1c5aa8b9124b2035a4076e5d2b7991c522c8acabfacabdc0e0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>elderly</topic><topic>erectile dysfunction</topic><topic>mouse</topic><topic>scrotum</topic><topic>stem cell</topic><topic>umbilical cord blood mononuclear cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Jiang, Yinghong</creatorcontrib><creatorcontrib>Xue, Wei</creatorcontrib><creatorcontrib>Liu, Lejiang</creatorcontrib><creatorcontrib>Yu, Hua</creatorcontrib><creatorcontrib>Zhang, Xuemei</creatorcontrib><creatorcontrib>Ye, Xiao</creatorcontrib><creatorcontrib>Miao, Jianrong</creatorcontrib><creatorcontrib>Liu, Jianling</creatorcontrib><creatorcontrib>Chen, Yueen</creatorcontrib><creatorcontrib>Lan, Xingbin</creatorcontrib><creatorcontrib>Liu, Xiaoqing</creatorcontrib><creatorcontrib>Yao, Wensong</creatorcontrib><creatorcontrib>Sun, Jianchuan</creatorcontrib><creatorcontrib>Zheng, Jing</creatorcontrib><creatorcontrib>Xiao, Jianzhong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regenerative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jun</au><au>Jiang, Yinghong</au><au>Xue, Wei</au><au>Liu, Lejiang</au><au>Yu, Hua</au><au>Zhang, Xuemei</au><au>Ye, Xiao</au><au>Miao, Jianrong</au><au>Liu, Jianling</au><au>Chen, Yueen</au><au>Lan, Xingbin</au><au>Liu, Xiaoqing</au><au>Yao, Wensong</au><au>Sun, Jianchuan</au><au>Zheng, Jing</au><au>Xiao, Jianzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice</atitle><jtitle>Regenerative medicine</jtitle><addtitle>Regen Med</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>18</volume><issue>9</issue><spage>695</spage><epage>706</epage><pages>695-706</pages><issn>1746-0751</issn><eissn>1746-076X</eissn><abstract>This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice.
UCBMCs were injected once into the scrotal sheath cavity of elderly mice.
The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000).
Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>37554102</pmid><doi>10.2217/rme-2022-0191</doi><tpages>12</tpages></addata></record> |
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| subjects | elderly erectile dysfunction mouse scrotum stem cell umbilical cord blood mononuclear cells |
| title | Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice |
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