Proanthocyanidins inhibited colorectal cancer stem cell characteristics through Wnt/β-catenin signaling

Cancer stem cells (CSCs) play a key role in tumor cell growth, drug resistance, recurrence, and metastasis. Proanthocyanidins (PC) is widely existed in plants and endowed with powerful antioxidant and anti-aging effects. Interestingly, recent studies have found that PC exhibits the inhibitory effect...

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Veröffentlicht in:	Environmental toxicology 2023-12, Vol.38 (12), p.2894-2903
Hauptverfasser:	Chen, Yuzhuo, Yang, Zhirong, He, Xingqiang, Zhu, Wanglong, Wang, Yujun, Li, Jiaofeng, Han, Zhengyu, Wen, Jie, Liu, Wei, Yang, Yuhan, Zhang, Kun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging (natural) Cancer Catenin Cell growth Cell proliferation Cell viability Cholecystokinin Colonies Colorectal cancer Colorectal carcinoma Dishevelled protein Drug resistance Drugs Lithium chloride Metastases Molecular modelling Mouse devices Neoplasms New class Oxaliplatin Proanthocyanidins Proliferation Proteins Sensitivity enhancement Stem cell transplantation Stem cells Transcription factors Tumorigenicity Tumors Western blotting Wnt protein Xenotransplantation
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