Hypoxia activation attenuates progesterone synthesis in goat trophoblast cells via NR1D1 inhibition of StAR expression

Trophoblast plays a crucial role in gestation maintenance and embryo implantation, partly due to the synthesis of progesterone. It has been demonstrated that hypoxia regulates invasion, proliferation, and differentiation of trophoblast cells. Additionally, human trophoblasts display rhythmic express...

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Veröffentlicht in:	Biology of reproduction 2023-11, Vol.109 (5), p.720-735
Hauptverfasser:	Li, Chao, Yang, Dan, Yang, Wanghao, Wang, Yiqun, Li, Dan, Li, Yating, Xiao, Bonan, Zhang, Haisen, Zhao, Hongcong, Dong, Hao, Zhang, Jing, Chu, Guiyan, Wang, Aihua, Jin, Yaping, Liu, Yingqiu, Chen, Huatao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BMAL1 protein Cell differentiation Cell proliferation circadian clock Circadian rhythm Circadian rhythms Cobalt Forskolin Gene expression Goats - genetics Humans Hypoxia Immunofluorescence NR1D1 Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism Progesterone RESEARCH ARTICLE RNA, Messenger steroid hormone synthesis trophoblast cells Trophoblasts Trophoblasts - metabolism Western blotting
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