Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal women without osteoporosis: A systematic review of randomized clinical trials
Menopause and vitamin D deficiency increase bone reabsorption and bone fracture risk in women in postmenopause, and vitamin D supplementation may improve bone health and decrease bone fracture risk. This study aims to discuss the effect of vitamin D supplementation, isolated or calcium-associated, o...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2023-12, Vol.116, p.112151, Article 112151 |
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| creator | Reis, Aline Rocha Santos, Ramara Kadija Fonseca Dos Santos, Cynthia Batista Santos, Beatriz da Cruz de Carvalho, Gabrielli Barbosa Brandão-Lima, Paula Nascimento de Oliveira E Silva, Ana Mara Pires, Liliane Viana |
| description | Menopause and vitamin D deficiency increase bone reabsorption and bone fracture risk in women in postmenopause, and vitamin D supplementation may improve bone health and decrease bone fracture risk. This study aims to discuss the effect of vitamin D supplementation, isolated or calcium-associated, on remodeling and fracture risk bone in women in postmenopause without osteoporosis. This study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO database registration: CRD42022359796). A search was conducted in four databases and gray literature using MeSH and similar terms related to supplements, vitamin D, calcium, remodeling, and fracture bone, without the restriction of language and year of publication. A total of 3460 studies were identified, and nine were selected. Vitamin D supplementation increased 25-hydroxyvitamin D levels ≥10 ng/mL and decreased parathyroid hormone secretion dependent on baseline levels. The doses of 400 IU of vitamin D improved the percentage of carboxylated osteocalcin, whereas 800 to 1000 IU combined with calcium resulted in reduced, improved, or maintained bone mineral density and reduced alkaline phosphatase levels. However, 4000 IU alone or combined with calcium for 6 mo did not improve C-telopeptide and procollagen type 1 peptide levels. Additionally, 15 000 IU/wk increased the cortical area of metacarpal bone, whereas 500 000 IU of vitamin D annually for 5 y did not contribute to reducing the fracture risk and falls. Only one study found a reduction in fracture risk (dose of 800 IU of vitamin D plus 1200 mg of calcium). Thus, the vitamin D supplementation, alone or calcium-associated, improved the status of 25-hydroxyvitamin D and bone remodeling, but it was not possible to assert that it reduced fracture bone risk in postmenopausal women. |
| doi_str_mv | 10.1016/j.nut.2023.112151 |
| format | Article |
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This study aims to discuss the effect of vitamin D supplementation, isolated or calcium-associated, on remodeling and fracture risk bone in women in postmenopause without osteoporosis. This study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO database registration: CRD42022359796). A search was conducted in four databases and gray literature using MeSH and similar terms related to supplements, vitamin D, calcium, remodeling, and fracture bone, without the restriction of language and year of publication. A total of 3460 studies were identified, and nine were selected. Vitamin D supplementation increased 25-hydroxyvitamin D levels ≥10 ng/mL and decreased parathyroid hormone secretion dependent on baseline levels. The doses of 400 IU of vitamin D improved the percentage of carboxylated osteocalcin, whereas 800 to 1000 IU combined with calcium resulted in reduced, improved, or maintained bone mineral density and reduced alkaline phosphatase levels. However, 4000 IU alone or combined with calcium for 6 mo did not improve C-telopeptide and procollagen type 1 peptide levels. Additionally, 15 000 IU/wk increased the cortical area of metacarpal bone, whereas 500 000 IU of vitamin D annually for 5 y did not contribute to reducing the fracture risk and falls. Only one study found a reduction in fracture risk (dose of 800 IU of vitamin D plus 1200 mg of calcium). Thus, the vitamin D supplementation, alone or calcium-associated, improved the status of 25-hydroxyvitamin D and bone remodeling, but it was not possible to assert that it reduced fracture bone risk in postmenopausal women.</description><identifier>ISSN: 0899-9007</identifier><identifier>ISSN: 1873-1244</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2023.112151</identifier><identifier>PMID: 37544189</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>25-Hydroxyvitamin D ; Agreements ; Alkaline phosphatase ; Bias ; Bone density ; Bone mineral density ; Bone Remodeling ; Calcifediol ; Calciferol ; Calcium ; Calcium, Dietary ; Clinical trials ; Collaboration ; Cortical bone ; Dietary Supplements ; Estrogens ; Female ; Fractures ; Fractures, Bone - drug therapy ; Fractures, Bone - etiology ; Fractures, Bone - prevention & control ; Homeostasis ; Humans ; Menopause ; Metabolism ; Metacarpal ; Osteocalcin ; Osteoporosis ; Parathyroid hormone ; Phosphatase ; Post-menopause ; Postmenopause ; Procollagen ; Randomized Controlled Trials as Topic ; Reabsorption ; Risk ; Software ; Systematic review ; Vitamin D ; Vitamin D - therapeutic use ; Vitamin deficiency ; Vitamins - therapeutic use ; Womens health</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2023-12, Vol.116, p.112151, Article 112151</ispartof><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><rights>2023. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-63dc7a81b60413d3f9eee4bfbabf71e2e50e0d7667f56345dee8bdc08587f9e93</citedby><cites>FETCH-LOGICAL-c329t-63dc7a81b60413d3f9eee4bfbabf71e2e50e0d7667f56345dee8bdc08587f9e93</cites><orcidid>0000-0003-1710-0836 ; 0000-0002-0949-361X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2889067408?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37544189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reis, Aline Rocha</creatorcontrib><creatorcontrib>Santos, Ramara Kadija Fonseca</creatorcontrib><creatorcontrib>Dos Santos, Cynthia Batista</creatorcontrib><creatorcontrib>Santos, Beatriz da Cruz</creatorcontrib><creatorcontrib>de Carvalho, Gabrielli Barbosa</creatorcontrib><creatorcontrib>Brandão-Lima, Paula Nascimento</creatorcontrib><creatorcontrib>de Oliveira E Silva, Ana Mara</creatorcontrib><creatorcontrib>Pires, Liliane Viana</creatorcontrib><title>Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal women without osteoporosis: A systematic review of randomized clinical trials</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Menopause and vitamin D deficiency increase bone reabsorption and bone fracture risk in women in postmenopause, and vitamin D supplementation may improve bone health and decrease bone fracture risk. This study aims to discuss the effect of vitamin D supplementation, isolated or calcium-associated, on remodeling and fracture risk bone in women in postmenopause without osteoporosis. This study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO database registration: CRD42022359796). A search was conducted in four databases and gray literature using MeSH and similar terms related to supplements, vitamin D, calcium, remodeling, and fracture bone, without the restriction of language and year of publication. A total of 3460 studies were identified, and nine were selected. Vitamin D supplementation increased 25-hydroxyvitamin D levels ≥10 ng/mL and decreased parathyroid hormone secretion dependent on baseline levels. The doses of 400 IU of vitamin D improved the percentage of carboxylated osteocalcin, whereas 800 to 1000 IU combined with calcium resulted in reduced, improved, or maintained bone mineral density and reduced alkaline phosphatase levels. However, 4000 IU alone or combined with calcium for 6 mo did not improve C-telopeptide and procollagen type 1 peptide levels. Additionally, 15 000 IU/wk increased the cortical area of metacarpal bone, whereas 500 000 IU of vitamin D annually for 5 y did not contribute to reducing the fracture risk and falls. Only one study found a reduction in fracture risk (dose of 800 IU of vitamin D plus 1200 mg of calcium). Thus, the vitamin D supplementation, alone or calcium-associated, improved the status of 25-hydroxyvitamin D and bone remodeling, but it was not possible to assert that it reduced fracture bone risk in postmenopausal women.</description><subject>25-Hydroxyvitamin D</subject><subject>Agreements</subject><subject>Alkaline phosphatase</subject><subject>Bias</subject><subject>Bone density</subject><subject>Bone mineral density</subject><subject>Bone Remodeling</subject><subject>Calcifediol</subject><subject>Calciferol</subject><subject>Calcium</subject><subject>Calcium, Dietary</subject><subject>Clinical trials</subject><subject>Collaboration</subject><subject>Cortical bone</subject><subject>Dietary Supplements</subject><subject>Estrogens</subject><subject>Female</subject><subject>Fractures</subject><subject>Fractures, Bone - drug therapy</subject><subject>Fractures, Bone - etiology</subject><subject>Fractures, Bone - prevention & control</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Menopause</subject><subject>Metabolism</subject><subject>Metacarpal</subject><subject>Osteocalcin</subject><subject>Osteoporosis</subject><subject>Parathyroid hormone</subject><subject>Phosphatase</subject><subject>Post-menopause</subject><subject>Postmenopause</subject><subject>Procollagen</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Reabsorption</subject><subject>Risk</subject><subject>Software</subject><subject>Systematic review</subject><subject>Vitamin D</subject><subject>Vitamin D - 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drug therapy</topic><topic>Fractures, Bone - etiology</topic><topic>Fractures, Bone - prevention & control</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Menopause</topic><topic>Metabolism</topic><topic>Metacarpal</topic><topic>Osteocalcin</topic><topic>Osteoporosis</topic><topic>Parathyroid hormone</topic><topic>Phosphatase</topic><topic>Post-menopause</topic><topic>Postmenopause</topic><topic>Procollagen</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Reabsorption</topic><topic>Risk</topic><topic>Software</topic><topic>Systematic review</topic><topic>Vitamin D</topic><topic>Vitamin D - therapeutic use</topic><topic>Vitamin deficiency</topic><topic>Vitamins - therapeutic use</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reis, Aline Rocha</creatorcontrib><creatorcontrib>Santos, Ramara Kadija Fonseca</creatorcontrib><creatorcontrib>Dos Santos, Cynthia Batista</creatorcontrib><creatorcontrib>Santos, Beatriz da Cruz</creatorcontrib><creatorcontrib>de Carvalho, Gabrielli Barbosa</creatorcontrib><creatorcontrib>Brandão-Lima, Paula Nascimento</creatorcontrib><creatorcontrib>de Oliveira E Silva, Ana Mara</creatorcontrib><creatorcontrib>Pires, Liliane Viana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Health Management Database (Proquest)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest_Research Library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reis, Aline Rocha</au><au>Santos, Ramara Kadija Fonseca</au><au>Dos Santos, Cynthia Batista</au><au>Santos, Beatriz da Cruz</au><au>de Carvalho, Gabrielli Barbosa</au><au>Brandão-Lima, Paula Nascimento</au><au>de Oliveira E Silva, Ana Mara</au><au>Pires, Liliane Viana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal women without osteoporosis: A systematic review of randomized clinical trials</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2023-12</date><risdate>2023</risdate><volume>116</volume><spage>112151</spage><pages>112151-</pages><artnum>112151</artnum><issn>0899-9007</issn><issn>1873-1244</issn><eissn>1873-1244</eissn><abstract>Menopause and vitamin D deficiency increase bone reabsorption and bone fracture risk in women in postmenopause, and vitamin D supplementation may improve bone health and decrease bone fracture risk. This study aims to discuss the effect of vitamin D supplementation, isolated or calcium-associated, on remodeling and fracture risk bone in women in postmenopause without osteoporosis. This study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO database registration: CRD42022359796). A search was conducted in four databases and gray literature using MeSH and similar terms related to supplements, vitamin D, calcium, remodeling, and fracture bone, without the restriction of language and year of publication. A total of 3460 studies were identified, and nine were selected. Vitamin D supplementation increased 25-hydroxyvitamin D levels ≥10 ng/mL and decreased parathyroid hormone secretion dependent on baseline levels. The doses of 400 IU of vitamin D improved the percentage of carboxylated osteocalcin, whereas 800 to 1000 IU combined with calcium resulted in reduced, improved, or maintained bone mineral density and reduced alkaline phosphatase levels. However, 4000 IU alone or combined with calcium for 6 mo did not improve C-telopeptide and procollagen type 1 peptide levels. Additionally, 15 000 IU/wk increased the cortical area of metacarpal bone, whereas 500 000 IU of vitamin D annually for 5 y did not contribute to reducing the fracture risk and falls. Only one study found a reduction in fracture risk (dose of 800 IU of vitamin D plus 1200 mg of calcium). Thus, the vitamin D supplementation, alone or calcium-associated, improved the status of 25-hydroxyvitamin D and bone remodeling, but it was not possible to assert that it reduced fracture bone risk in postmenopausal women.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>37544189</pmid><doi>10.1016/j.nut.2023.112151</doi><orcidid>https://orcid.org/0000-0003-1710-0836</orcidid><orcidid>https://orcid.org/0000-0002-0949-361X</orcidid></addata></record> |
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| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2023-12, Vol.116, p.112151, Article 112151 |
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| subjects | 25-Hydroxyvitamin D Agreements Alkaline phosphatase Bias Bone density Bone mineral density Bone Remodeling Calcifediol Calciferol Calcium Calcium, Dietary Clinical trials Collaboration Cortical bone Dietary Supplements Estrogens Female Fractures Fractures, Bone - drug therapy Fractures, Bone - etiology Fractures, Bone - prevention & control Homeostasis Humans Menopause Metabolism Metacarpal Osteocalcin Osteoporosis Parathyroid hormone Phosphatase Post-menopause Postmenopause Procollagen Randomized Controlled Trials as Topic Reabsorption Risk Software Systematic review Vitamin D Vitamin D - therapeutic use Vitamin deficiency Vitamins - therapeutic use Womens health |
| title | Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal women without osteoporosis: A systematic review of randomized clinical trials |
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