Exploration of mRNA nanoparticles based on DOTAP through optimization of the helper lipids

Lipid nanoparticles (LNPs) are one of the most efficient carriers for RNA packaging and delivery, and vaccines based on mRNA‐LNPs have received substantial attention since the outbreak of the COVID‐19 pandemic. LNPs based on 1,2‐dioleoyl‐3‐trimethylammonium propane (DOTAP) have been widely used in p...

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Veröffentlicht in:	Biotechnology journal 2023-11, Vol.18 (11), p.e2300123-n/a
Hauptverfasser:	Ma, Xueni, Wu, Fanqi, Peng, Caihong, Chen, Huiling, Zhang, Dekui, Han, Tiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	DOTAP helper lipids lipid nanoparticles mRNA delivery non‐phospholipids SARS‐CoV‐2 spike antibody
Online-Zugang:	Volltext
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