Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short‐term negative side effects in horses
Objective To evaluate corneal sensitivity and acute side effects following application of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% on the healthy equine cornea. Animals Studied Eight healthy adult horses. Procedure A randomized, masked, crossover study design was utilized. Basel...
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| Veröffentlicht in: | Veterinary ophthalmology 2023-09, Vol.26 (5), p.446-451 |
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| creator | Minaldi, Michael P. Fidler, Laura E. Betbeze, Caroline M. Wills, Robert Fontenot, Robin L. Telle, Mary R. |
| description | Objective
To evaluate corneal sensitivity and acute side effects following application of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% on the healthy equine cornea.
Animals Studied
Eight healthy adult horses.
Procedure
A randomized, masked, crossover study design was utilized. Baseline Semiquantitative Preclinical Ocular Toxicology (SPOT) scores and corneal touch thresholds (CTT) using a Cochet‐Bonnet esthesiometer were recorded and measured, respectively, for eight healthy adult horses before medication application. Commercially available eyewash was used as a negative control. Ropivacaine hydrochloride 0.5% or lidocaine hydrochloride 2% solution was sprayed on a randomly selected eye, and the contralateral eye received eyewash. CTT was measured in both eyes at 1, 5, 15, 25, 35, 45, 55, 65, and 75 min post‐application. Post‐application SPOT scores were recorded immediately following the trial. Linear mixed model statistical analyses (mean ± standard error) were performed (p |
| doi_str_mv | 10.1111/vop.13137 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2847341953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2847341953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2857-d45ab3236bb27ae906d65cb83a24e67fb009eec0f40fd01bbee10eddc3fa26123</originalsourceid><addsrcrecordid>eNp1kTtOAzEQQC0E4l9wAeQGCYoE_3Y3KVHET0KCAmhXXntMjDZ2sL1B23EE7sDNOAmGABVMMyPN02seQnuUDGme44WfDymnvFpBm1SUfFAwJlZ_b1puoK0YHwkhvCDVOtrgVSFGVPBN9Hbr51bJFoe8F1JJ6wBPex28mrY-WA2YDIsDLJ3GrdX-L4Ad4GgfnDVZ5FLb4wC6U4CVDw6yOoKLNtmFTT1-tmnqu4Tj1If0_vKaIMywgweZ_5A1WQfGgEoRW4czFCHuoDUj2wi733sb3Z2d3k4uBlfX55eTk6uBYqOiGmhRyIYzXjYNqySMSanLQjUjLpmAsjINIWMARYwgRhPaNACUgNaKG8lKyvg2Olx658E_dRBTPbNRQdtKB76LNRuJigs6LnhGj5aoCj7GAKaeBzuToa8pqT-b1LlJ_dUks_vf2q6Zgf4lfyJk4HgJPNsW-v9N9f31zVL5ATIIm6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2847341953</pqid></control><display><type>article</type><title>Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short‐term negative side effects in horses</title><source>Access via Wiley Online Library</source><creator>Minaldi, Michael P. ; Fidler, Laura E. ; Betbeze, Caroline M. ; Wills, Robert ; Fontenot, Robin L. ; Telle, Mary R.</creator><creatorcontrib>Minaldi, Michael P. ; Fidler, Laura E. ; Betbeze, Caroline M. ; Wills, Robert ; Fontenot, Robin L. ; Telle, Mary R.</creatorcontrib><description>Objective
To evaluate corneal sensitivity and acute side effects following application of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% on the healthy equine cornea.
Animals Studied
Eight healthy adult horses.
Procedure
A randomized, masked, crossover study design was utilized. Baseline Semiquantitative Preclinical Ocular Toxicology (SPOT) scores and corneal touch thresholds (CTT) using a Cochet‐Bonnet esthesiometer were recorded and measured, respectively, for eight healthy adult horses before medication application. Commercially available eyewash was used as a negative control. Ropivacaine hydrochloride 0.5% or lidocaine hydrochloride 2% solution was sprayed on a randomly selected eye, and the contralateral eye received eyewash. CTT was measured in both eyes at 1, 5, 15, 25, 35, 45, 55, 65, and 75 min post‐application. Post‐application SPOT scores were recorded immediately following the trial. Linear mixed model statistical analyses (mean ± standard error) were performed (p < .05).
Results
Mean eyewash CTT (3.41 cm ± 0.464) was significantly different from ropivacaine‐treated (1.44 cm ± 0.562) (p = .008) and lidocaine‐treated eyes (1.75 cm ± 0.562) (p = .024); CTT was not significantly different between drug groups (p = .88). Time to maximum anesthesia was not significantly different between ropivacaine (13.25 min ± 3.353) and lidocaine (16.25 min ± 3.353) (p = .40). No side effects were appreciated as confirmed by SPOT.
Conclusions
Ropivacaine and lidocaine similarly decreased corneal sensitivity when applied topically without clinically evident short‐term ocular side effects. Lidocaine may be preferable in clinical settings due to its large, multi‐use vials and similar effects to ropivacaine.</description><identifier>ISSN: 1463-5216</identifier><identifier>EISSN: 1463-5224</identifier><identifier>DOI: 10.1111/vop.13137</identifier><identifier>PMID: 37548143</identifier><language>eng</language><publisher>England</publisher><subject>corneal touch threshold ; esthesiometry ; horse ; sensitivity ; topical anesthesia</subject><ispartof>Veterinary ophthalmology, 2023-09, Vol.26 (5), p.446-451</ispartof><rights>2023 American College of Veterinary Ophthalmologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2857-d45ab3236bb27ae906d65cb83a24e67fb009eec0f40fd01bbee10eddc3fa26123</cites><orcidid>0000-0001-6487-8371 ; 0000-0003-2169-8834 ; 0000-0002-8956-4819</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvop.13137$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvop.13137$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37548143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minaldi, Michael P.</creatorcontrib><creatorcontrib>Fidler, Laura E.</creatorcontrib><creatorcontrib>Betbeze, Caroline M.</creatorcontrib><creatorcontrib>Wills, Robert</creatorcontrib><creatorcontrib>Fontenot, Robin L.</creatorcontrib><creatorcontrib>Telle, Mary R.</creatorcontrib><title>Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short‐term negative side effects in horses</title><title>Veterinary ophthalmology</title><addtitle>Vet Ophthalmol</addtitle><description>Objective
To evaluate corneal sensitivity and acute side effects following application of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% on the healthy equine cornea.
Animals Studied
Eight healthy adult horses.
Procedure
A randomized, masked, crossover study design was utilized. Baseline Semiquantitative Preclinical Ocular Toxicology (SPOT) scores and corneal touch thresholds (CTT) using a Cochet‐Bonnet esthesiometer were recorded and measured, respectively, for eight healthy adult horses before medication application. Commercially available eyewash was used as a negative control. Ropivacaine hydrochloride 0.5% or lidocaine hydrochloride 2% solution was sprayed on a randomly selected eye, and the contralateral eye received eyewash. CTT was measured in both eyes at 1, 5, 15, 25, 35, 45, 55, 65, and 75 min post‐application. Post‐application SPOT scores were recorded immediately following the trial. Linear mixed model statistical analyses (mean ± standard error) were performed (p < .05).
Results
Mean eyewash CTT (3.41 cm ± 0.464) was significantly different from ropivacaine‐treated (1.44 cm ± 0.562) (p = .008) and lidocaine‐treated eyes (1.75 cm ± 0.562) (p = .024); CTT was not significantly different between drug groups (p = .88). Time to maximum anesthesia was not significantly different between ropivacaine (13.25 min ± 3.353) and lidocaine (16.25 min ± 3.353) (p = .40). No side effects were appreciated as confirmed by SPOT.
Conclusions
Ropivacaine and lidocaine similarly decreased corneal sensitivity when applied topically without clinically evident short‐term ocular side effects. Lidocaine may be preferable in clinical settings due to its large, multi‐use vials and similar effects to ropivacaine.</description><subject>corneal touch threshold</subject><subject>esthesiometry</subject><subject>horse</subject><subject>sensitivity</subject><subject>topical anesthesia</subject><issn>1463-5216</issn><issn>1463-5224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kTtOAzEQQC0E4l9wAeQGCYoE_3Y3KVHET0KCAmhXXntMjDZ2sL1B23EE7sDNOAmGABVMMyPN02seQnuUDGme44WfDymnvFpBm1SUfFAwJlZ_b1puoK0YHwkhvCDVOtrgVSFGVPBN9Hbr51bJFoe8F1JJ6wBPex28mrY-WA2YDIsDLJ3GrdX-L4Ad4GgfnDVZ5FLb4wC6U4CVDw6yOoKLNtmFTT1-tmnqu4Tj1If0_vKaIMywgweZ_5A1WQfGgEoRW4czFCHuoDUj2wi733sb3Z2d3k4uBlfX55eTk6uBYqOiGmhRyIYzXjYNqySMSanLQjUjLpmAsjINIWMARYwgRhPaNACUgNaKG8lKyvg2Olx658E_dRBTPbNRQdtKB76LNRuJigs6LnhGj5aoCj7GAKaeBzuToa8pqT-b1LlJ_dUks_vf2q6Zgf4lfyJk4HgJPNsW-v9N9f31zVL5ATIIm6w</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Minaldi, Michael P.</creator><creator>Fidler, Laura E.</creator><creator>Betbeze, Caroline M.</creator><creator>Wills, Robert</creator><creator>Fontenot, Robin L.</creator><creator>Telle, Mary R.</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6487-8371</orcidid><orcidid>https://orcid.org/0000-0003-2169-8834</orcidid><orcidid>https://orcid.org/0000-0002-8956-4819</orcidid></search><sort><creationdate>202309</creationdate><title>Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short‐term negative side effects in horses</title><author>Minaldi, Michael P. ; Fidler, Laura E. ; Betbeze, Caroline M. ; Wills, Robert ; Fontenot, Robin L. ; Telle, Mary R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2857-d45ab3236bb27ae906d65cb83a24e67fb009eec0f40fd01bbee10eddc3fa26123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>corneal touch threshold</topic><topic>esthesiometry</topic><topic>horse</topic><topic>sensitivity</topic><topic>topical anesthesia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minaldi, Michael P.</creatorcontrib><creatorcontrib>Fidler, Laura E.</creatorcontrib><creatorcontrib>Betbeze, Caroline M.</creatorcontrib><creatorcontrib>Wills, Robert</creatorcontrib><creatorcontrib>Fontenot, Robin L.</creatorcontrib><creatorcontrib>Telle, Mary R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minaldi, Michael P.</au><au>Fidler, Laura E.</au><au>Betbeze, Caroline M.</au><au>Wills, Robert</au><au>Fontenot, Robin L.</au><au>Telle, Mary R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short‐term negative side effects in horses</atitle><jtitle>Veterinary ophthalmology</jtitle><addtitle>Vet Ophthalmol</addtitle><date>2023-09</date><risdate>2023</risdate><volume>26</volume><issue>5</issue><spage>446</spage><epage>451</epage><pages>446-451</pages><issn>1463-5216</issn><eissn>1463-5224</eissn><abstract>Objective
To evaluate corneal sensitivity and acute side effects following application of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% on the healthy equine cornea.
Animals Studied
Eight healthy adult horses.
Procedure
A randomized, masked, crossover study design was utilized. Baseline Semiquantitative Preclinical Ocular Toxicology (SPOT) scores and corneal touch thresholds (CTT) using a Cochet‐Bonnet esthesiometer were recorded and measured, respectively, for eight healthy adult horses before medication application. Commercially available eyewash was used as a negative control. Ropivacaine hydrochloride 0.5% or lidocaine hydrochloride 2% solution was sprayed on a randomly selected eye, and the contralateral eye received eyewash. CTT was measured in both eyes at 1, 5, 15, 25, 35, 45, 55, 65, and 75 min post‐application. Post‐application SPOT scores were recorded immediately following the trial. Linear mixed model statistical analyses (mean ± standard error) were performed (p < .05).
Results
Mean eyewash CTT (3.41 cm ± 0.464) was significantly different from ropivacaine‐treated (1.44 cm ± 0.562) (p = .008) and lidocaine‐treated eyes (1.75 cm ± 0.562) (p = .024); CTT was not significantly different between drug groups (p = .88). Time to maximum anesthesia was not significantly different between ropivacaine (13.25 min ± 3.353) and lidocaine (16.25 min ± 3.353) (p = .40). No side effects were appreciated as confirmed by SPOT.
Conclusions
Ropivacaine and lidocaine similarly decreased corneal sensitivity when applied topically without clinically evident short‐term ocular side effects. Lidocaine may be preferable in clinical settings due to its large, multi‐use vials and similar effects to ropivacaine.</abstract><cop>England</cop><pmid>37548143</pmid><doi>10.1111/vop.13137</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6487-8371</orcidid><orcidid>https://orcid.org/0000-0003-2169-8834</orcidid><orcidid>https://orcid.org/0000-0002-8956-4819</orcidid></addata></record> |
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| source | Access via Wiley Online Library |
| subjects | corneal touch threshold esthesiometry horse sensitivity topical anesthesia |
| title | Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short‐term negative side effects in horses |
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