Study on the Mechanism of Eerdun Wurile’s Effects on Post-operative Cognitive Dysfunction by the TLR4/NF-κB Pathway

The object of our work was to observe whether the Mongolian medicine Eerdun Wurile (EW) improve postoperative cognitive dysfunction (POCD) by affecting the TLR4/NF-κB. Mice (6–8-week-old male C57BL/6 J) were selected to establish an animal model of POCD by combining intracerebroventricular injection...

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Veröffentlicht in:	Molecular neurobiology 2023-12, Vol.60 (12), p.7274-7284
Hauptverfasser:	Qiao, Yun, Li, Huiru, Li, Yan, Su, Enboer, Wang, Zhe, Che, Limuge, Du, Yiri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animal models Animals Biomedical and Life Sciences Biomedicine Cell Biology Cognitive ability Cognitive Dysfunction Cytokines Enzyme-linked immunosorbent assay Hippocampus IL-1β Inflammation Interleukin 6 Ligands Lipopolysaccharides Lipopolysaccharides - pharmacology Male Medical research Medicine Memory Mice Mice, Inbred C57BL Microglia MyD88 protein Myeloid Differentiation Factor 88 Nephrectomy Nervous system Neurobiology Neurological disorders Neurology Neurosciences NF-kappa B NF-κB protein Nitric-oxide synthase Postoperative Cognitive Complications Secretions Surgery TLR4 protein Toll-Like Receptor 4 Toll-like receptors Trauma Tumor Necrosis Factor-alpha Tumor necrosis factor-α Western blotting
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