Complexity in the immune system
The immune system is a real-time example of an evolving system that navigates the essentially infinite complexity of protein sequence space. How this system responds to disease and vaccination is discussed. Of particular focus is the case when vaccination leads to increased susceptibility to disease...
Gespeichert in:
| Veröffentlicht in: | Computers & chemical engineering 2005-02, Vol.29 (3), p.437-446 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 446 |
|---|---|
| container_issue | 3 |
| container_start_page | 437 |
| container_title | Computers & chemical engineering |
| container_volume | 29 |
| creator | Deem, Michael W. |
| description | The immune system is a real-time example of an evolving system that navigates the essentially infinite complexity of protein sequence space. How this system responds to disease and vaccination is discussed. Of particular focus is the case when vaccination leads to increased susceptibility to disease, a phenomenon termed original antigenic sin. A physical theory of protein evolution to explain limitations in the immune system response to vaccination and disease is discussed, and original antigenic sin is explained as stemming from localization of the immune system response in antibody sequence space. This localization is a result of the roughness in sequence space of the evolved antibody affinity constant for antigen and is observed for diseases with high year-to-year mutation rates, such as influenza. |
| doi_str_mv | 10.1016/j.compchemeng.2004.08.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_28471753</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0098135404002340</els_id><sourcerecordid>28471753</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-e6d14a7d2a5703671e869743be477edd43a3af5093e1c4a26f2db7ba434f733a3</originalsourceid><addsrcrecordid>eNqNkDtPwzAUhS0EEqXwGwgLW8L1I7EzooiXVIkFZsuxb6irOCl2iui_J1UZGJnucM53pPsRckOhoECru01hx7C1aww4fBQMQBSgCqDlCVlQJXkuuCxPyQKgVjnlpTgnFyltAIAJpRbkupnxHr_9tM_8kE1rzHwIuwGztE8Thkty1pk-4dXvXZL3x4e35jlfvT69NPer3PKSTTlWjgojHTOlBF5JiqqqpeAtCinROcENN10JNUdqhWFVx1wrWyO46CSfwyW5Pe5u4_i5wzTp4JPFvjcDjrukmRKSypLPxfpYtHFMKWKnt9EHE_eagj4o0Rv9R4k-KNGg9KxkZpsji_MnXx6jTtbjYNH5iHbSbvT_WPkBuJBvOA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>28471753</pqid></control><display><type>article</type><title>Complexity in the immune system</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Deem, Michael W.</creator><creatorcontrib>Deem, Michael W.</creatorcontrib><description>The immune system is a real-time example of an evolving system that navigates the essentially infinite complexity of protein sequence space. How this system responds to disease and vaccination is discussed. Of particular focus is the case when vaccination leads to increased susceptibility to disease, a phenomenon termed original antigenic sin. A physical theory of protein evolution to explain limitations in the immune system response to vaccination and disease is discussed, and original antigenic sin is explained as stemming from localization of the immune system response in antibody sequence space. This localization is a result of the roughness in sequence space of the evolved antibody affinity constant for antigen and is observed for diseases with high year-to-year mutation rates, such as influenza.</description><identifier>ISSN: 0098-1354</identifier><identifier>EISSN: 1873-4375</identifier><identifier>DOI: 10.1016/j.compchemeng.2004.08.015</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Complexity ; Immune system ; Influenza ; Original antigenic sin</subject><ispartof>Computers & chemical engineering, 2005-02, Vol.29 (3), p.437-446</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-e6d14a7d2a5703671e869743be477edd43a3af5093e1c4a26f2db7ba434f733a3</citedby><cites>FETCH-LOGICAL-c352t-e6d14a7d2a5703671e869743be477edd43a3af5093e1c4a26f2db7ba434f733a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0098135404002340$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Deem, Michael W.</creatorcontrib><title>Complexity in the immune system</title><title>Computers & chemical engineering</title><description>The immune system is a real-time example of an evolving system that navigates the essentially infinite complexity of protein sequence space. How this system responds to disease and vaccination is discussed. Of particular focus is the case when vaccination leads to increased susceptibility to disease, a phenomenon termed original antigenic sin. A physical theory of protein evolution to explain limitations in the immune system response to vaccination and disease is discussed, and original antigenic sin is explained as stemming from localization of the immune system response in antibody sequence space. This localization is a result of the roughness in sequence space of the evolved antibody affinity constant for antigen and is observed for diseases with high year-to-year mutation rates, such as influenza.</description><subject>Complexity</subject><subject>Immune system</subject><subject>Influenza</subject><subject>Original antigenic sin</subject><issn>0098-1354</issn><issn>1873-4375</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkDtPwzAUhS0EEqXwGwgLW8L1I7EzooiXVIkFZsuxb6irOCl2iui_J1UZGJnucM53pPsRckOhoECru01hx7C1aww4fBQMQBSgCqDlCVlQJXkuuCxPyQKgVjnlpTgnFyltAIAJpRbkupnxHr_9tM_8kE1rzHwIuwGztE8Thkty1pk-4dXvXZL3x4e35jlfvT69NPer3PKSTTlWjgojHTOlBF5JiqqqpeAtCinROcENN10JNUdqhWFVx1wrWyO46CSfwyW5Pe5u4_i5wzTp4JPFvjcDjrukmRKSypLPxfpYtHFMKWKnt9EHE_eagj4o0Rv9R4k-KNGg9KxkZpsji_MnXx6jTtbjYNH5iHbSbvT_WPkBuJBvOA</recordid><startdate>20050215</startdate><enddate>20050215</enddate><creator>Deem, Michael W.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SC</scope><scope>8FD</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20050215</creationdate><title>Complexity in the immune system</title><author>Deem, Michael W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-e6d14a7d2a5703671e869743be477edd43a3af5093e1c4a26f2db7ba434f733a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Complexity</topic><topic>Immune system</topic><topic>Influenza</topic><topic>Original antigenic sin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deem, Michael W.</creatorcontrib><collection>CrossRef</collection><collection>Computer and Information Systems Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Computers & chemical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deem, Michael W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complexity in the immune system</atitle><jtitle>Computers & chemical engineering</jtitle><date>2005-02-15</date><risdate>2005</risdate><volume>29</volume><issue>3</issue><spage>437</spage><epage>446</epage><pages>437-446</pages><issn>0098-1354</issn><eissn>1873-4375</eissn><abstract>The immune system is a real-time example of an evolving system that navigates the essentially infinite complexity of protein sequence space. How this system responds to disease and vaccination is discussed. Of particular focus is the case when vaccination leads to increased susceptibility to disease, a phenomenon termed original antigenic sin. A physical theory of protein evolution to explain limitations in the immune system response to vaccination and disease is discussed, and original antigenic sin is explained as stemming from localization of the immune system response in antibody sequence space. This localization is a result of the roughness in sequence space of the evolved antibody affinity constant for antigen and is observed for diseases with high year-to-year mutation rates, such as influenza.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.compchemeng.2004.08.015</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0098-1354 |
| ispartof | Computers & chemical engineering, 2005-02, Vol.29 (3), p.437-446 |
| issn | 0098-1354 1873-4375 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_28471753 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Complexity Immune system Influenza Original antigenic sin |
| title | Complexity in the immune system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T11%3A55%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Complexity%20in%20the%20immune%20system&rft.jtitle=Computers%20&%20chemical%20engineering&rft.au=Deem,%20Michael%20W.&rft.date=2005-02-15&rft.volume=29&rft.issue=3&rft.spage=437&rft.epage=446&rft.pages=437-446&rft.issn=0098-1354&rft.eissn=1873-4375&rft_id=info:doi/10.1016/j.compchemeng.2004.08.015&rft_dat=%3Cproquest_cross%3E28471753%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=28471753&rft_id=info:pmid/&rft_els_id=S0098135404002340&rfr_iscdi=true |