Adult-onset chronic recurrent multifocal osteomyelitis: a case report
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease predominantly affecting the metaphyses of long bones and is usually seen in children. Although CRMO is generally a pediatric disease, it may also occur in adults. This may result in a delay in the diagnosis of adul...
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| Veröffentlicht in: | Skeletal radiology 2024-02, Vol.53 (2), p.395-400 |
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| creator | Yılmaz, Ebru İncesoy, Mustafa Alper |
| description | Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease predominantly affecting the metaphyses of long bones and is usually seen in children. Although CRMO is generally a pediatric disease, it may also occur in adults. This may result in a delay in the diagnosis of adult-onset CRMO. This report presents an adult-onset female patient who presented with left leg pain followed by swelling in the right knee. The patient was initially started on colchicine treatment, but, due to unresponsiveness in the follow-up the patient, the treatment was switched to a combination of methotrexate and prednisolone. A satisfactory clinical recovery was achieved with these drugs. CRMO could be considered in the differential diagnosis of patients presenting with bone pain and joint complaints. Considering that the disease progresses with clinical flare-ups and remission periods, it should be kept in mind that patients should be followed closely and treatment can be changed. |
| doi_str_mv | 10.1007/s00256-023-04413-5 |
| format | Article |
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Although CRMO is generally a pediatric disease, it may also occur in adults. This may result in a delay in the diagnosis of adult-onset CRMO. This report presents an adult-onset female patient who presented with left leg pain followed by swelling in the right knee. The patient was initially started on colchicine treatment, but, due to unresponsiveness in the follow-up the patient, the treatment was switched to a combination of methotrexate and prednisolone. A satisfactory clinical recovery was achieved with these drugs. CRMO could be considered in the differential diagnosis of patients presenting with bone pain and joint complaints. 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Although CRMO is generally a pediatric disease, it may also occur in adults. This may result in a delay in the diagnosis of adult-onset CRMO. This report presents an adult-onset female patient who presented with left leg pain followed by swelling in the right knee. The patient was initially started on colchicine treatment, but, due to unresponsiveness in the follow-up the patient, the treatment was switched to a combination of methotrexate and prednisolone. A satisfactory clinical recovery was achieved with these drugs. CRMO could be considered in the differential diagnosis of patients presenting with bone pain and joint complaints. Considering that the disease progresses with clinical flare-ups and remission periods, it should be kept in mind that patients should be followed closely and treatment can be changed.</description><subject>Adult</subject><subject>Antibiotics</subject><subject>Back pain</subject><subject>Biopsy</subject><subject>Bone and Bones</subject><subject>Bone diseases</subject><subject>Bone marrow</subject><subject>Bones</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Colchicine</subject><subject>Complaints</subject><subject>Complaints management</subject><subject>Diagnosis</subject><subject>Differential diagnosis</subject><subject>Edema</subject><subject>Female</subject><subject>Females</subject><subject>Health services</subject><subject>Humans</subject><subject>Imaging</subject><subject>Laboratories</subject><subject>Long bone</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methotrexate</subject><subject>Microorganisms</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Nuclear Medicine</subject><subject>Orthopedics</subject><subject>Osteomyelitis</subject><subject>Osteomyelitis - diagnostic imaging</subject><subject>Osteomyelitis - drug therapy</subject><subject>Outpatient care facilities</subject><subject>Pain</subject><subject>Pathology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Prednisolone</subject><subject>Prednisolone - therapeutic use</subject><subject>Radiology</subject><subject>Remission</subject><subject>Scintigraphy</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0EoqXwAgwoEguL4fiahK2qykWqxAKzFTsOpEriYjtD3x6XcpEYmM5wvv8_Rx9C5wSuCUB-EwCokBgow8A5YVgcoCnhjGJKJDlEU2CSY8p4MUEnIawBSJ4LeYwmLBc8ZckULef12EXshmBjZt68G1qTeWtG7-0Qsz4t28aZqstciNb1W9u1sQ23WZWZKtiEbpyPp-ioqbpgz77mDL3cLZ8XD3j1dP-4mK-wYVRGLMqmLjXoijMidFGXpgawtGCamVpzkGDy9KMG1kgQ0AhtSyZsTmte5AXRbIau9r0b795HG6Lq22Bs11WDdWNQtOCyTN2CJvTyD7p2ox_Sd4qWwHJaSikSRfeU8S4Ebxu18W1f-a0ioHaS1V6ySpLVp2S1C118VY-6t_VP5NtqAtgeCGk1vFr_e_uf2g-I2IZJ</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Yılmaz, Ebru</creator><creator>İncesoy, Mustafa Alper</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0275-8101</orcidid><orcidid>https://orcid.org/0000-0003-2172-2742</orcidid></search><sort><creationdate>20240201</creationdate><title>Adult-onset chronic recurrent multifocal osteomyelitis: a case report</title><author>Yılmaz, Ebru ; İncesoy, Mustafa Alper</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-59fd9b0ba4315b8d9cd00e283b3cdb4060c7017b03f6050f5be935e72d48781b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Antibiotics</topic><topic>Back pain</topic><topic>Biopsy</topic><topic>Bone and Bones</topic><topic>Bone diseases</topic><topic>Bone marrow</topic><topic>Bones</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>Colchicine</topic><topic>Complaints</topic><topic>Complaints management</topic><topic>Diagnosis</topic><topic>Differential diagnosis</topic><topic>Edema</topic><topic>Female</topic><topic>Females</topic><topic>Health services</topic><topic>Humans</topic><topic>Imaging</topic><topic>Laboratories</topic><topic>Long bone</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methotrexate</topic><topic>Microorganisms</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Nuclear Medicine</topic><topic>Orthopedics</topic><topic>Osteomyelitis</topic><topic>Osteomyelitis - diagnostic imaging</topic><topic>Osteomyelitis - drug therapy</topic><topic>Outpatient care facilities</topic><topic>Pain</topic><topic>Pathology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Prednisolone</topic><topic>Prednisolone - therapeutic use</topic><topic>Radiology</topic><topic>Remission</topic><topic>Scintigraphy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yılmaz, Ebru</creatorcontrib><creatorcontrib>İncesoy, Mustafa Alper</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Skeletal radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yılmaz, Ebru</au><au>İncesoy, Mustafa Alper</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult-onset chronic recurrent multifocal osteomyelitis: a case report</atitle><jtitle>Skeletal radiology</jtitle><stitle>Skeletal Radiol</stitle><addtitle>Skeletal Radiol</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>53</volume><issue>2</issue><spage>395</spage><epage>400</epage><pages>395-400</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><abstract>Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease predominantly affecting the metaphyses of long bones and is usually seen in children. Although CRMO is generally a pediatric disease, it may also occur in adults. This may result in a delay in the diagnosis of adult-onset CRMO. This report presents an adult-onset female patient who presented with left leg pain followed by swelling in the right knee. The patient was initially started on colchicine treatment, but, due to unresponsiveness in the follow-up the patient, the treatment was switched to a combination of methotrexate and prednisolone. A satisfactory clinical recovery was achieved with these drugs. CRMO could be considered in the differential diagnosis of patients presenting with bone pain and joint complaints. 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| subjects | Adult Antibiotics Back pain Biopsy Bone and Bones Bone diseases Bone marrow Bones Case Report Case reports Child Chronic Disease Colchicine Complaints Complaints management Diagnosis Differential diagnosis Edema Female Females Health services Humans Imaging Laboratories Long bone Magnetic resonance imaging Medicine Medicine & Public Health Methotrexate Microorganisms Nonsteroidal anti-inflammatory drugs Nuclear Medicine Orthopedics Osteomyelitis Osteomyelitis - diagnostic imaging Osteomyelitis - drug therapy Outpatient care facilities Pain Pathology Patients Pediatrics Prednisolone Prednisolone - therapeutic use Radiology Remission Scintigraphy |
| title | Adult-onset chronic recurrent multifocal osteomyelitis: a case report |
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