Transdermal drug delivery via microneedles for musculoskeletal systems
As the population is ageing and lifestyle is changing, the prevalence of musculoskeletal (MSK) disorders is gradually increasing with each passing year, posing a serious threat to the health and quality of the public, especially the elderly. However, currently prevalent treatments for MSK disorders,...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-09, Vol.11 (35), p.8327-8346 |
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| container_issue | 35 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Zheng, Haibin Xie, Xuankun Ling, Haocong You, Xintong Liang, Siyu Lin, Rurong Qiu, Renjie Hou, Honghao |
| description | As the population is ageing and lifestyle is changing, the prevalence of musculoskeletal (MSK) disorders is gradually increasing with each passing year, posing a serious threat to the health and quality of the public, especially the elderly. However, currently prevalent treatments for MSK disorders, mainly administered orally and by injection, are not targeted to the specific lesion, resulting in low efficacy along with a series of local and systemic adverse effects. Microneedle (MN) patches loaded with micron-sized needle array, combining the advantages of oral administration and local injection, have become a potentially novel strategy for the administration and treatment of MSK diseases. In this review, we briefly introduce the basics of MNs and focus on the main characteristics of the MSK systems and various types of MN-based transdermal drug delivery (TDD) systems. We emphasize the progress and broad applications of MN-based transdermal drug delivery (TDD) for MSK systems, including osteoporosis, nutritional rickets and some other typical types of arthritis and muscular damage, and in closing summarize the future prospects and challenges of MNs application. |
| doi_str_mv | 10.1039/d3tb01441j |
| format | Article |
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However, currently prevalent treatments for MSK disorders, mainly administered orally and by injection, are not targeted to the specific lesion, resulting in low efficacy along with a series of local and systemic adverse effects. Microneedle (MN) patches loaded with micron-sized needle array, combining the advantages of oral administration and local injection, have become a potentially novel strategy for the administration and treatment of MSK diseases. In this review, we briefly introduce the basics of MNs and focus on the main characteristics of the MSK systems and various types of MN-based transdermal drug delivery (TDD) systems. 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We emphasize the progress and broad applications of MN-based transdermal drug delivery (TDD) for MSK systems, including osteoporosis, nutritional rickets and some other typical types of arthritis and muscular damage, and in closing summarize the future prospects and challenges of MNs application.</description><subject>Disorders</subject><subject>Drug delivery</subject><subject>Geriatrics</subject><subject>Health risks</subject><subject>Injection</subject><subject>Needles</subject><subject>Oral administration</subject><subject>Osteoporosis</subject><subject>Rickets</subject><subject>Transdermal medication</subject><issn>2050-750X</issn><issn>2050-7518</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0E1LwzAYB_AgihtzFz-AFLyIUM1b0-So0_nCwMsEbyVNn0hn2s6kHezbG930YC5PDr_8efJH6JTgK4KZuq5YX2LCOVkdoDHFGU7zjMjDvzt-G6FpCCscjyRCMn6MRizPmBI0G6P50us2VOAb7ZLKD-9JBa7egN8mm1onTW181wJUDkJiO580QzCD68IHOOjjk7ANPTThBB1Z7QJM93OCXuf3y9ljunh5eJrdLFLDMtGnYKlRpTQgFeGSAiuZokRYTqnkZa7zXBNRSQtgLWfGmoormeGoGFCNgU3QxS537bvPAUJfNHUw4JxuoRtCEWOEYjjLaaTn_-iqG3wbt4tKcIIF5yqqy52K_wzBgy3Wvm603xYEF98FF3dseftT8HPEZ_vIoWyg-qO_dbIvUMp15A</recordid><startdate>20230913</startdate><enddate>20230913</enddate><creator>Zheng, Haibin</creator><creator>Xie, Xuankun</creator><creator>Ling, Haocong</creator><creator>You, Xintong</creator><creator>Liang, Siyu</creator><creator>Lin, Rurong</creator><creator>Qiu, Renjie</creator><creator>Hou, Honghao</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7133-9760</orcidid></search><sort><creationdate>20230913</creationdate><title>Transdermal drug delivery via microneedles for musculoskeletal systems</title><author>Zheng, Haibin ; Xie, Xuankun ; Ling, Haocong ; You, Xintong ; Liang, Siyu ; Lin, Rurong ; Qiu, Renjie ; Hou, Honghao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ef2c9b8ce891482e3b39216f42284b7a77a16d8feeff43cfcd49850b393e2a0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Disorders</topic><topic>Drug delivery</topic><topic>Geriatrics</topic><topic>Health risks</topic><topic>Injection</topic><topic>Needles</topic><topic>Oral administration</topic><topic>Osteoporosis</topic><topic>Rickets</topic><topic>Transdermal medication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Haibin</creatorcontrib><creatorcontrib>Xie, Xuankun</creatorcontrib><creatorcontrib>Ling, Haocong</creatorcontrib><creatorcontrib>You, Xintong</creatorcontrib><creatorcontrib>Liang, Siyu</creatorcontrib><creatorcontrib>Lin, Rurong</creatorcontrib><creatorcontrib>Qiu, Renjie</creatorcontrib><creatorcontrib>Hou, Honghao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. 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Microneedle (MN) patches loaded with micron-sized needle array, combining the advantages of oral administration and local injection, have become a potentially novel strategy for the administration and treatment of MSK diseases. In this review, we briefly introduce the basics of MNs and focus on the main characteristics of the MSK systems and various types of MN-based transdermal drug delivery (TDD) systems. We emphasize the progress and broad applications of MN-based transdermal drug delivery (TDD) for MSK systems, including osteoporosis, nutritional rickets and some other typical types of arthritis and muscular damage, and in closing summarize the future prospects and challenges of MNs application.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37539625</pmid><doi>10.1039/d3tb01441j</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-7133-9760</orcidid></addata></record> |
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| source | Royal Society Of Chemistry Journals |
| subjects | Disorders Drug delivery Geriatrics Health risks Injection Needles Oral administration Osteoporosis Rickets Transdermal medication |
| title | Transdermal drug delivery via microneedles for musculoskeletal systems |
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