SIRT1 and SIRT6: The role in aging-related diseases
Aging is characterized by progressive functional deterioration with increased risk of mortality. It is a complex biological process driven by a multitude of intertwined mechanisms such as increased DNA damage, chronic inflammation, and metabolic dysfunction. Sirtuins (SIRTs) are a family of NAD+-dep...
Gespeichert in:
| Veröffentlicht in: | Biochimica et biophysica acta. Molecular basis of disease 2023-10, Vol.1869 (7), p.166815-166815, Article 166815 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 166815 |
|---|---|
| container_issue | 7 |
| container_start_page | 166815 |
| container_title | Biochimica et biophysica acta. Molecular basis of disease |
| container_volume | 1869 |
| creator | You, Yuzi Liang, Wei |
| description | Aging is characterized by progressive functional deterioration with increased risk of mortality. It is a complex biological process driven by a multitude of intertwined mechanisms such as increased DNA damage, chronic inflammation, and metabolic dysfunction. Sirtuins (SIRTs) are a family of NAD+-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy metabolism and tumorigenesis. Of the seven mammalian SIRT isotypes (SIRT1–7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective role of SIRT1 and SIRT6 in aging-related diseases at molecular, cellular, tissue, and whole-organism levels. We also discuss the therapeutic potential of SIRT1 and SIRT6 modulators in the treatment of these diseases and challenges thereof.
•Overview of Sirts' role in aging and aging-related diseases.•Pathophysiological roles and biological interactions of SIRT1 and SIRT6 in aging.•Promising pharmaceutical treatments by interventing Sirts activities. |
| doi_str_mv | 10.1016/j.bbadis.2023.166815 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2846928812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0925443923001813</els_id><sourcerecordid>2846928812</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-b846177bbdadb45f76d51a2ebb479e1baa34a08a79feeb5401243b0c0f7fbc9b3</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMotlb_gcgs3UxNMplk4kKQ4gsKglZwF_K4U1OmMzWZCv57U6a69G7uXZxzD-dD6JzgKcGEX62mxmjn45RiWkwJ5xUpD9CYVELmlOP3QzTGkpY5Y4UcoZMYVzgNF_gYjQrBpJS0GqPi9ellQTLdumx38ets8QFZ6BrIfJvppW-XeYBG9-CyFAY6QjxFR7VuIpzt9wS93d8tZo_5_PnhaXY7zy3DVZ-binEihDFOO8PKWnBXEk3BGCYkEKN1wTSutJA1gCkZJpQVBltci9pYaYoJuhz-bkL3uYXYq7WPFppGt9Bto6IpIJWoCE1SNkht6GIMUKtN8GsdvhXBaodLrdSAS-1wqQFXsl3sE7ZmDe7P9MsnCW4GAaSeXx6CitZDa8H5ALZXrvP_J_wAcah7QQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2846928812</pqid></control><display><type>article</type><title>SIRT1 and SIRT6: The role in aging-related diseases</title><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>You, Yuzi ; Liang, Wei</creator><creatorcontrib>You, Yuzi ; Liang, Wei</creatorcontrib><description>Aging is characterized by progressive functional deterioration with increased risk of mortality. It is a complex biological process driven by a multitude of intertwined mechanisms such as increased DNA damage, chronic inflammation, and metabolic dysfunction. Sirtuins (SIRTs) are a family of NAD+-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy metabolism and tumorigenesis. Of the seven mammalian SIRT isotypes (SIRT1–7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective role of SIRT1 and SIRT6 in aging-related diseases at molecular, cellular, tissue, and whole-organism levels. We also discuss the therapeutic potential of SIRT1 and SIRT6 modulators in the treatment of these diseases and challenges thereof.
•Overview of Sirts' role in aging and aging-related diseases.•Pathophysiological roles and biological interactions of SIRT1 and SIRT6 in aging.•Promising pharmaceutical treatments by interventing Sirts activities.</description><identifier>ISSN: 0925-4439</identifier><identifier>EISSN: 1879-260X</identifier><identifier>DOI: 10.1016/j.bbadis.2023.166815</identifier><identifier>PMID: 37499928</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aging ; Aging-related diseases ; SIRT1 ; SIRT6 ; Sirtuins</subject><ispartof>Biochimica et biophysica acta. Molecular basis of disease, 2023-10, Vol.1869 (7), p.166815-166815, Article 166815</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-b846177bbdadb45f76d51a2ebb479e1baa34a08a79feeb5401243b0c0f7fbc9b3</citedby><cites>FETCH-LOGICAL-c408t-b846177bbdadb45f76d51a2ebb479e1baa34a08a79feeb5401243b0c0f7fbc9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbadis.2023.166815$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37499928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>You, Yuzi</creatorcontrib><creatorcontrib>Liang, Wei</creatorcontrib><title>SIRT1 and SIRT6: The role in aging-related diseases</title><title>Biochimica et biophysica acta. Molecular basis of disease</title><addtitle>Biochim Biophys Acta Mol Basis Dis</addtitle><description>Aging is characterized by progressive functional deterioration with increased risk of mortality. It is a complex biological process driven by a multitude of intertwined mechanisms such as increased DNA damage, chronic inflammation, and metabolic dysfunction. Sirtuins (SIRTs) are a family of NAD+-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy metabolism and tumorigenesis. Of the seven mammalian SIRT isotypes (SIRT1–7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective role of SIRT1 and SIRT6 in aging-related diseases at molecular, cellular, tissue, and whole-organism levels. We also discuss the therapeutic potential of SIRT1 and SIRT6 modulators in the treatment of these diseases and challenges thereof.
•Overview of Sirts' role in aging and aging-related diseases.•Pathophysiological roles and biological interactions of SIRT1 and SIRT6 in aging.•Promising pharmaceutical treatments by interventing Sirts activities.</description><subject>Aging</subject><subject>Aging-related diseases</subject><subject>SIRT1</subject><subject>SIRT6</subject><subject>Sirtuins</subject><issn>0925-4439</issn><issn>1879-260X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhYMotlb_gcgs3UxNMplk4kKQ4gsKglZwF_K4U1OmMzWZCv57U6a69G7uXZxzD-dD6JzgKcGEX62mxmjn45RiWkwJ5xUpD9CYVELmlOP3QzTGkpY5Y4UcoZMYVzgNF_gYjQrBpJS0GqPi9ellQTLdumx38ets8QFZ6BrIfJvppW-XeYBG9-CyFAY6QjxFR7VuIpzt9wS93d8tZo_5_PnhaXY7zy3DVZ-binEihDFOO8PKWnBXEk3BGCYkEKN1wTSutJA1gCkZJpQVBltci9pYaYoJuhz-bkL3uYXYq7WPFppGt9Bto6IpIJWoCE1SNkht6GIMUKtN8GsdvhXBaodLrdSAS-1wqQFXsl3sE7ZmDe7P9MsnCW4GAaSeXx6CitZDa8H5ALZXrvP_J_wAcah7QQ</recordid><startdate>202310</startdate><enddate>202310</enddate><creator>You, Yuzi</creator><creator>Liang, Wei</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202310</creationdate><title>SIRT1 and SIRT6: The role in aging-related diseases</title><author>You, Yuzi ; Liang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-b846177bbdadb45f76d51a2ebb479e1baa34a08a79feeb5401243b0c0f7fbc9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aging</topic><topic>Aging-related diseases</topic><topic>SIRT1</topic><topic>SIRT6</topic><topic>Sirtuins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>You, Yuzi</creatorcontrib><creatorcontrib>Liang, Wei</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimica et biophysica acta. Molecular basis of disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>You, Yuzi</au><au>Liang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SIRT1 and SIRT6: The role in aging-related diseases</atitle><jtitle>Biochimica et biophysica acta. Molecular basis of disease</jtitle><addtitle>Biochim Biophys Acta Mol Basis Dis</addtitle><date>2023-10</date><risdate>2023</risdate><volume>1869</volume><issue>7</issue><spage>166815</spage><epage>166815</epage><pages>166815-166815</pages><artnum>166815</artnum><issn>0925-4439</issn><eissn>1879-260X</eissn><abstract>Aging is characterized by progressive functional deterioration with increased risk of mortality. It is a complex biological process driven by a multitude of intertwined mechanisms such as increased DNA damage, chronic inflammation, and metabolic dysfunction. Sirtuins (SIRTs) are a family of NAD+-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy metabolism and tumorigenesis. Of the seven mammalian SIRT isotypes (SIRT1–7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective role of SIRT1 and SIRT6 in aging-related diseases at molecular, cellular, tissue, and whole-organism levels. We also discuss the therapeutic potential of SIRT1 and SIRT6 modulators in the treatment of these diseases and challenges thereof.
•Overview of Sirts' role in aging and aging-related diseases.•Pathophysiological roles and biological interactions of SIRT1 and SIRT6 in aging.•Promising pharmaceutical treatments by interventing Sirts activities.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37499928</pmid><doi>10.1016/j.bbadis.2023.166815</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0925-4439 |
| ispartof | Biochimica et biophysica acta. Molecular basis of disease, 2023-10, Vol.1869 (7), p.166815-166815, Article 166815 |
| issn | 0925-4439 1879-260X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2846928812 |
| source | Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aging Aging-related diseases SIRT1 SIRT6 Sirtuins |
| title | SIRT1 and SIRT6: The role in aging-related diseases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A25%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SIRT1%20and%20SIRT6:%20The%20role%20in%20aging-related%20diseases&rft.jtitle=Biochimica%20et%20biophysica%20acta.%20Molecular%20basis%20of%20disease&rft.au=You,%20Yuzi&rft.date=2023-10&rft.volume=1869&rft.issue=7&rft.spage=166815&rft.epage=166815&rft.pages=166815-166815&rft.artnum=166815&rft.issn=0925-4439&rft.eissn=1879-260X&rft_id=info:doi/10.1016/j.bbadis.2023.166815&rft_dat=%3Cproquest_cross%3E2846928812%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2846928812&rft_id=info:pmid/37499928&rft_els_id=S0925443923001813&rfr_iscdi=true |