Effects of exercise on immune cells with tumor-specific activity in breast cancer patients and survivors: a systematic review and meta-analysis
Exercise is effective for improving the physical and psychological health of breast cancer patients. However, there is still controversy around its role on the immune system. Therefore, this systematic review and meta-analysis is aimed to evaluate the effect of chronic exercise on the number and act...
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| Veröffentlicht in: | Supportive care in cancer 2023-09, Vol.31 (9), p.507, Article 507 |
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| creator | Lavín-Pérez, Ana Myriam Collado-Mateo, Daniel Abbasi, Shaghayegh Ferreira-Júnior, João B Hekmatikar, Amir Hossein Ahmadi |
| description | Exercise is effective for improving the physical and psychological health of breast cancer patients. However, there is still controversy around its role on the immune system. Therefore, this systematic review and meta-analysis is aimed to evaluate the effect of chronic exercise on the number and activity of the immune cells that can contribute to anti-tumor immune responses, such as natural killers (NK) cells, CD + 4, or CD + 8. The main hypothesis of this study was that exercise could improve the immune system or, at least, there will not be a reduction in the number or activity of immune cells because of exercise. The search was conducted in the PubMed and Web of Science databases. Out of 244 studies reviewed, 10 studies met the inclusion criteria. The studies included in the meta-analyses showed mixed results and no significant (
p
> 0.05) positive or negative effects of exercise interventions in women with breast cancer. Therefore, the current evidence indicates that exercise does not significantly improve or reduce the immune system; thus, the prescription of exercise must not be discouraged due to the effects on the number and activity of immune system cells, but should be recommended due to the well-known benefits in quality of life, physical function or fatigue, and the absence of negative effects on the immune system. Further studies are needed to evaluate the effects according to the type of exercise, the type of cancer, or the timing of the intervention. |
| doi_str_mv | 10.1007/s00520-023-07968-0 |
| format | Article |
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p
> 0.05) positive or negative effects of exercise interventions in women with breast cancer. Therefore, the current evidence indicates that exercise does not significantly improve or reduce the immune system; thus, the prescription of exercise must not be discouraged due to the effects on the number and activity of immune system cells, but should be recommended due to the well-known benefits in quality of life, physical function or fatigue, and the absence of negative effects on the immune system. Further studies are needed to evaluate the effects according to the type of exercise, the type of cancer, or the timing of the intervention.</description><identifier>ISSN: 0941-4355</identifier><identifier>ISSN: 1433-7339</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-023-07968-0</identifier><identifier>PMID: 37542543</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Breast cancer ; Breast Neoplasms - psychology ; Breast Neoplasms - therapy ; Care and treatment ; Exercise ; Exercise - physiology ; Exercise therapy ; Female ; Humans ; Immune response ; Immune system ; Medicine ; Medicine & Public Health ; Mental Health ; Meta-analysis ; Nursing ; Nursing Research ; Oncology ; Pain Medicine ; Quality of Life ; Rehabilitation Medicine ; Review ; Survivor ; Survivors ; Systematic review</subject><ispartof>Supportive care in cancer, 2023-09, Vol.31 (9), p.507, Article 507</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-35c658cffe411e4ec9a9fbcb74ccd9300cacd4603ea557844b7dedd21e7bc74b3</citedby><cites>FETCH-LOGICAL-c442t-35c658cffe411e4ec9a9fbcb74ccd9300cacd4603ea557844b7dedd21e7bc74b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-023-07968-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-023-07968-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37542543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lavín-Pérez, Ana Myriam</creatorcontrib><creatorcontrib>Collado-Mateo, Daniel</creatorcontrib><creatorcontrib>Abbasi, Shaghayegh</creatorcontrib><creatorcontrib>Ferreira-Júnior, João B</creatorcontrib><creatorcontrib>Hekmatikar, Amir Hossein Ahmadi</creatorcontrib><title>Effects of exercise on immune cells with tumor-specific activity in breast cancer patients and survivors: a systematic review and meta-analysis</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Exercise is effective for improving the physical and psychological health of breast cancer patients. However, there is still controversy around its role on the immune system. Therefore, this systematic review and meta-analysis is aimed to evaluate the effect of chronic exercise on the number and activity of the immune cells that can contribute to anti-tumor immune responses, such as natural killers (NK) cells, CD + 4, or CD + 8. The main hypothesis of this study was that exercise could improve the immune system or, at least, there will not be a reduction in the number or activity of immune cells because of exercise. The search was conducted in the PubMed and Web of Science databases. Out of 244 studies reviewed, 10 studies met the inclusion criteria. The studies included in the meta-analyses showed mixed results and no significant (
p
> 0.05) positive or negative effects of exercise interventions in women with breast cancer. Therefore, the current evidence indicates that exercise does not significantly improve or reduce the immune system; thus, the prescription of exercise must not be discouraged due to the effects on the number and activity of immune system cells, but should be recommended due to the well-known benefits in quality of life, physical function or fatigue, and the absence of negative effects on the immune system. Further studies are needed to evaluate the effects according to the type of exercise, the type of cancer, or the timing of the intervention.</description><subject>Analysis</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - psychology</subject><subject>Breast Neoplasms - therapy</subject><subject>Care and treatment</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental Health</subject><subject>Meta-analysis</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Pain Medicine</subject><subject>Quality of Life</subject><subject>Rehabilitation Medicine</subject><subject>Review</subject><subject>Survivor</subject><subject>Survivors</subject><subject>Systematic review</subject><issn>0941-4355</issn><issn>1433-7339</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kkFv1DAQhSMEokvhD3BAlrhwcXFie51wq6oClSpxgbPlTCbFVWIvHmfb_RX8ZbzdQlWEkA-WPN97eiO_qnpdi5NaCPOehNCN4KKRXJhu3XLxpFrVSkpupOyeVivRqZorqfVR9YLoWojaGN08r46k0arRSq6qn-fjiJCJxZHhLSbwhCwG5ud5CcgAp4nYjc_fWV7mmDhtEPzogTnIfuvzjvnA-oSOMgMXABPbuOwxFEsXBkZL2vptTPSBOUY7yjiXMbCEW483d8iM2XEX3LQjTy-rZ6ObCF_d38fVt4_nX88-88svny7OTi85KNVkLjWsdQslu6prVAid68YeeqMAhk4KAQ4GtRYSndamVao3Aw5DU6PpwaheHlfvDr6bFH8sSNnOnvbbuoBxIdu0at01xihV0Ld_oddxSSXvgZKdEW3zQF25Ca0PY8zJwd7UnhrdtbXWShTq5B9UOQPOHmLA0Zf3R4LmIIAUiRKOdpP87NLO1sLuW2APLbClBfauBXYvenOfeOlnHP5Ifn97AeQBoDIKV5geVvqP7S8D377l</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Lavín-Pérez, Ana Myriam</creator><creator>Collado-Mateo, Daniel</creator><creator>Abbasi, Shaghayegh</creator><creator>Ferreira-Júnior, João B</creator><creator>Hekmatikar, Amir Hossein Ahmadi</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20230901</creationdate><title>Effects of exercise on immune cells with tumor-specific activity in breast cancer patients and survivors: a systematic review and meta-analysis</title><author>Lavín-Pérez, Ana Myriam ; 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However, there is still controversy around its role on the immune system. Therefore, this systematic review and meta-analysis is aimed to evaluate the effect of chronic exercise on the number and activity of the immune cells that can contribute to anti-tumor immune responses, such as natural killers (NK) cells, CD + 4, or CD + 8. The main hypothesis of this study was that exercise could improve the immune system or, at least, there will not be a reduction in the number or activity of immune cells because of exercise. The search was conducted in the PubMed and Web of Science databases. Out of 244 studies reviewed, 10 studies met the inclusion criteria. The studies included in the meta-analyses showed mixed results and no significant (
p
> 0.05) positive or negative effects of exercise interventions in women with breast cancer. Therefore, the current evidence indicates that exercise does not significantly improve or reduce the immune system; thus, the prescription of exercise must not be discouraged due to the effects on the number and activity of immune system cells, but should be recommended due to the well-known benefits in quality of life, physical function or fatigue, and the absence of negative effects on the immune system. Further studies are needed to evaluate the effects according to the type of exercise, the type of cancer, or the timing of the intervention.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37542543</pmid><doi>10.1007/s00520-023-07968-0</doi></addata></record> |
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| ispartof | Supportive care in cancer, 2023-09, Vol.31 (9), p.507, Article 507 |
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| subjects | Analysis Breast cancer Breast Neoplasms - psychology Breast Neoplasms - therapy Care and treatment Exercise Exercise - physiology Exercise therapy Female Humans Immune response Immune system Medicine Medicine & Public Health Mental Health Meta-analysis Nursing Nursing Research Oncology Pain Medicine Quality of Life Rehabilitation Medicine Review Survivor Survivors Systematic review |
| title | Effects of exercise on immune cells with tumor-specific activity in breast cancer patients and survivors: a systematic review and meta-analysis |
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