Dysregulated miRNAs in recurrent miscarriage: A systematic review

•Recurrent Miscarriage is an unpleasant reproductive condition in females.•miRNAs are short sequences of non-coding RNAs with regulatory properties.•Finding suggests the possible correlation between miRNAs levels and miscarriage.•Using different mechanism miRNAs can affect the occurrence of miscarri...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Gene 2023-10, Vol.884, p.147689-147689, Article 147689
Hauptverfasser: Hakimi, Parvin, Tabatabaei, Fatemeh, Rahmani, Vahideh, Zakariya, Nahideh Afshar, Moslehian, Marziyeh Sadat, Bedate, Alberto Miranda, Tamadon, Amin, Rahbarghazi, Reza, Mahdipour, Mahdi
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 147689
container_issue
container_start_page 147689
container_title Gene
container_volume 884
creator Hakimi, Parvin
Tabatabaei, Fatemeh
Rahmani, Vahideh
Zakariya, Nahideh Afshar
Moslehian, Marziyeh Sadat
Bedate, Alberto Miranda
Tamadon, Amin
Rahbarghazi, Reza
Mahdipour, Mahdi
description •Recurrent Miscarriage is an unpleasant reproductive condition in females.•miRNAs are short sequences of non-coding RNAs with regulatory properties.•Finding suggests the possible correlation between miRNAs levels and miscarriage.•Using different mechanism miRNAs can affect the occurrence of miscarriage. Recurrent miscarriage (RM) is a complex reproductive medicine disease that affects many families. The cause of RM is unclear at this time; however, lifestyle and genetic variables may influence the process. The slight alteration in miRNA expression has enormous consequences for a variety of difficulties, one of which may be RM. The target of this systematic study was to provide a framework of the dysregulated miRNAs in RM. The Prisma guidelines were applied to perform current systematic review pertaining to articles in the seven databases. Thirty-nine papers out of 245 received fulfilled all inclusion requirements. From all the mentioned miRNAs, 40 were up-regulated (65.57 %), whereas 21 were down-regulated (34.43 %). These dysregulated miRNAs contributed to the pathophysiology of RM by influencing key pathways and processes such as apoptosis, angiogenesis, epithelial-mesenchymal transition, and the immune system. Understanding the dysregulation of miRNAs, as well as the pathways and processes that engage these miRNAs and impact disease pathogenesis, may aid in clarifying the unknown underlying mechanisms of RM and the development of novel molecular therapeutic targets and medical domains.
doi_str_mv 10.1016/j.gene.2023.147689
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2846927351</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378111923005309</els_id><sourcerecordid>2846927351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-4b84cf7804d1ed5b6e40d7f80b81fe4b87f7a036c79db5a8350b7252e440c52e3</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMozjj6Ai6kSzetubVJxc0wXmFQEF2HND0dMvSiSavM25vS0aXZHEi-85P_Q-ic4IRgkl1tkw20kFBMWUK4yGR-gOZEijzGmMlDNMdMyJgQks_QifdbHE6a0mM0YyLljFI8R8vbnXewGWrdQxk19vV56SPbRg7M4By0fbjzRjtn9Qauo2Xkd76HRvfWBObLwvcpOqp07eFsPxfo_f7ubfUYr18enlbLdWwYFn3MC8lNJSTmJYEyLTLguBSVxIUkFYRXUQmNWWZEXhaplizFhaApBc6xCYMt0OWU--G6zwF8r8afQV3rFrrBKyp5llPBUhJQOqHGdT7Uq9SHs412O0WwGtWprRrVqVGdmtSFpYt9_lA0UP6t_LoKwM0EQGgZmjvljYXWQGmDrV6Vnf0v_weuq37h</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2846927351</pqid></control><display><type>article</type><title>Dysregulated miRNAs in recurrent miscarriage: A systematic review</title><source>Access via ScienceDirect (Elsevier)</source><creator>Hakimi, Parvin ; Tabatabaei, Fatemeh ; Rahmani, Vahideh ; Zakariya, Nahideh Afshar ; Moslehian, Marziyeh Sadat ; Bedate, Alberto Miranda ; Tamadon, Amin ; Rahbarghazi, Reza ; Mahdipour, Mahdi</creator><creatorcontrib>Hakimi, Parvin ; Tabatabaei, Fatemeh ; Rahmani, Vahideh ; Zakariya, Nahideh Afshar ; Moslehian, Marziyeh Sadat ; Bedate, Alberto Miranda ; Tamadon, Amin ; Rahbarghazi, Reza ; Mahdipour, Mahdi</creatorcontrib><description>•Recurrent Miscarriage is an unpleasant reproductive condition in females.•miRNAs are short sequences of non-coding RNAs with regulatory properties.•Finding suggests the possible correlation between miRNAs levels and miscarriage.•Using different mechanism miRNAs can affect the occurrence of miscarriage. Recurrent miscarriage (RM) is a complex reproductive medicine disease that affects many families. The cause of RM is unclear at this time; however, lifestyle and genetic variables may influence the process. The slight alteration in miRNA expression has enormous consequences for a variety of difficulties, one of which may be RM. The target of this systematic study was to provide a framework of the dysregulated miRNAs in RM. The Prisma guidelines were applied to perform current systematic review pertaining to articles in the seven databases. Thirty-nine papers out of 245 received fulfilled all inclusion requirements. From all the mentioned miRNAs, 40 were up-regulated (65.57 %), whereas 21 were down-regulated (34.43 %). These dysregulated miRNAs contributed to the pathophysiology of RM by influencing key pathways and processes such as apoptosis, angiogenesis, epithelial-mesenchymal transition, and the immune system. Understanding the dysregulation of miRNAs, as well as the pathways and processes that engage these miRNAs and impact disease pathogenesis, may aid in clarifying the unknown underlying mechanisms of RM and the development of novel molecular therapeutic targets and medical domains.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2023.147689</identifier><identifier>PMID: 37543220</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Angiogenesis ; Apoptosis ; Epithelial-mesenchymal transition ; miRNA ; Recurrent miscarriage ; Systematic review</subject><ispartof>Gene, 2023-10, Vol.884, p.147689-147689, Article 147689</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c307t-4b84cf7804d1ed5b6e40d7f80b81fe4b87f7a036c79db5a8350b7252e440c52e3</cites><orcidid>0000-0002-0222-3035 ; 0000-0003-3864-9166 ; 0000-0002-2729-4593</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2023.147689$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37543220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hakimi, Parvin</creatorcontrib><creatorcontrib>Tabatabaei, Fatemeh</creatorcontrib><creatorcontrib>Rahmani, Vahideh</creatorcontrib><creatorcontrib>Zakariya, Nahideh Afshar</creatorcontrib><creatorcontrib>Moslehian, Marziyeh Sadat</creatorcontrib><creatorcontrib>Bedate, Alberto Miranda</creatorcontrib><creatorcontrib>Tamadon, Amin</creatorcontrib><creatorcontrib>Rahbarghazi, Reza</creatorcontrib><creatorcontrib>Mahdipour, Mahdi</creatorcontrib><title>Dysregulated miRNAs in recurrent miscarriage: A systematic review</title><title>Gene</title><addtitle>Gene</addtitle><description>•Recurrent Miscarriage is an unpleasant reproductive condition in females.•miRNAs are short sequences of non-coding RNAs with regulatory properties.•Finding suggests the possible correlation between miRNAs levels and miscarriage.•Using different mechanism miRNAs can affect the occurrence of miscarriage. Recurrent miscarriage (RM) is a complex reproductive medicine disease that affects many families. The cause of RM is unclear at this time; however, lifestyle and genetic variables may influence the process. The slight alteration in miRNA expression has enormous consequences for a variety of difficulties, one of which may be RM. The target of this systematic study was to provide a framework of the dysregulated miRNAs in RM. The Prisma guidelines were applied to perform current systematic review pertaining to articles in the seven databases. Thirty-nine papers out of 245 received fulfilled all inclusion requirements. From all the mentioned miRNAs, 40 were up-regulated (65.57 %), whereas 21 were down-regulated (34.43 %). These dysregulated miRNAs contributed to the pathophysiology of RM by influencing key pathways and processes such as apoptosis, angiogenesis, epithelial-mesenchymal transition, and the immune system. Understanding the dysregulation of miRNAs, as well as the pathways and processes that engage these miRNAs and impact disease pathogenesis, may aid in clarifying the unknown underlying mechanisms of RM and the development of novel molecular therapeutic targets and medical domains.</description><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Epithelial-mesenchymal transition</subject><subject>miRNA</subject><subject>Recurrent miscarriage</subject><subject>Systematic review</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMozjj6Ai6kSzetubVJxc0wXmFQEF2HND0dMvSiSavM25vS0aXZHEi-85P_Q-ic4IRgkl1tkw20kFBMWUK4yGR-gOZEijzGmMlDNMdMyJgQks_QifdbHE6a0mM0YyLljFI8R8vbnXewGWrdQxk19vV56SPbRg7M4By0fbjzRjtn9Qauo2Xkd76HRvfWBObLwvcpOqp07eFsPxfo_f7ubfUYr18enlbLdWwYFn3MC8lNJSTmJYEyLTLguBSVxIUkFYRXUQmNWWZEXhaplizFhaApBc6xCYMt0OWU--G6zwF8r8afQV3rFrrBKyp5llPBUhJQOqHGdT7Uq9SHs412O0WwGtWprRrVqVGdmtSFpYt9_lA0UP6t_LoKwM0EQGgZmjvljYXWQGmDrV6Vnf0v_weuq37h</recordid><startdate>20231030</startdate><enddate>20231030</enddate><creator>Hakimi, Parvin</creator><creator>Tabatabaei, Fatemeh</creator><creator>Rahmani, Vahideh</creator><creator>Zakariya, Nahideh Afshar</creator><creator>Moslehian, Marziyeh Sadat</creator><creator>Bedate, Alberto Miranda</creator><creator>Tamadon, Amin</creator><creator>Rahbarghazi, Reza</creator><creator>Mahdipour, Mahdi</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0222-3035</orcidid><orcidid>https://orcid.org/0000-0003-3864-9166</orcidid><orcidid>https://orcid.org/0000-0002-2729-4593</orcidid></search><sort><creationdate>20231030</creationdate><title>Dysregulated miRNAs in recurrent miscarriage: A systematic review</title><author>Hakimi, Parvin ; Tabatabaei, Fatemeh ; Rahmani, Vahideh ; Zakariya, Nahideh Afshar ; Moslehian, Marziyeh Sadat ; Bedate, Alberto Miranda ; Tamadon, Amin ; Rahbarghazi, Reza ; Mahdipour, Mahdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-4b84cf7804d1ed5b6e40d7f80b81fe4b87f7a036c79db5a8350b7252e440c52e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angiogenesis</topic><topic>Apoptosis</topic><topic>Epithelial-mesenchymal transition</topic><topic>miRNA</topic><topic>Recurrent miscarriage</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hakimi, Parvin</creatorcontrib><creatorcontrib>Tabatabaei, Fatemeh</creatorcontrib><creatorcontrib>Rahmani, Vahideh</creatorcontrib><creatorcontrib>Zakariya, Nahideh Afshar</creatorcontrib><creatorcontrib>Moslehian, Marziyeh Sadat</creatorcontrib><creatorcontrib>Bedate, Alberto Miranda</creatorcontrib><creatorcontrib>Tamadon, Amin</creatorcontrib><creatorcontrib>Rahbarghazi, Reza</creatorcontrib><creatorcontrib>Mahdipour, Mahdi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hakimi, Parvin</au><au>Tabatabaei, Fatemeh</au><au>Rahmani, Vahideh</au><au>Zakariya, Nahideh Afshar</au><au>Moslehian, Marziyeh Sadat</au><au>Bedate, Alberto Miranda</au><au>Tamadon, Amin</au><au>Rahbarghazi, Reza</au><au>Mahdipour, Mahdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dysregulated miRNAs in recurrent miscarriage: A systematic review</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2023-10-30</date><risdate>2023</risdate><volume>884</volume><spage>147689</spage><epage>147689</epage><pages>147689-147689</pages><artnum>147689</artnum><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>•Recurrent Miscarriage is an unpleasant reproductive condition in females.•miRNAs are short sequences of non-coding RNAs with regulatory properties.•Finding suggests the possible correlation between miRNAs levels and miscarriage.•Using different mechanism miRNAs can affect the occurrence of miscarriage. Recurrent miscarriage (RM) is a complex reproductive medicine disease that affects many families. The cause of RM is unclear at this time; however, lifestyle and genetic variables may influence the process. The slight alteration in miRNA expression has enormous consequences for a variety of difficulties, one of which may be RM. The target of this systematic study was to provide a framework of the dysregulated miRNAs in RM. The Prisma guidelines were applied to perform current systematic review pertaining to articles in the seven databases. Thirty-nine papers out of 245 received fulfilled all inclusion requirements. From all the mentioned miRNAs, 40 were up-regulated (65.57 %), whereas 21 were down-regulated (34.43 %). These dysregulated miRNAs contributed to the pathophysiology of RM by influencing key pathways and processes such as apoptosis, angiogenesis, epithelial-mesenchymal transition, and the immune system. Understanding the dysregulation of miRNAs, as well as the pathways and processes that engage these miRNAs and impact disease pathogenesis, may aid in clarifying the unknown underlying mechanisms of RM and the development of novel molecular therapeutic targets and medical domains.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37543220</pmid><doi>10.1016/j.gene.2023.147689</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0222-3035</orcidid><orcidid>https://orcid.org/0000-0003-3864-9166</orcidid><orcidid>https://orcid.org/0000-0002-2729-4593</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0378-1119
ispartof Gene, 2023-10, Vol.884, p.147689-147689, Article 147689
issn 0378-1119
1879-0038
language eng
recordid cdi_proquest_miscellaneous_2846927351
source Access via ScienceDirect (Elsevier)
subjects Angiogenesis
Apoptosis
Epithelial-mesenchymal transition
miRNA
Recurrent miscarriage
Systematic review
title Dysregulated miRNAs in recurrent miscarriage: A systematic review
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T09%3A38%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dysregulated%20miRNAs%20in%20recurrent%20miscarriage:%20A%20systematic%20review&rft.jtitle=Gene&rft.au=Hakimi,%20Parvin&rft.date=2023-10-30&rft.volume=884&rft.spage=147689&rft.epage=147689&rft.pages=147689-147689&rft.artnum=147689&rft.issn=0378-1119&rft.eissn=1879-0038&rft_id=info:doi/10.1016/j.gene.2023.147689&rft_dat=%3Cproquest_cross%3E2846927351%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2846927351&rft_id=info:pmid/37543220&rft_els_id=S0378111923005309&rfr_iscdi=true