Early clonal extinction in glioblastoma progression revealed by genetic barcoding

Glioblastoma progression in its early stages remains poorly understood. Here, we transfer PDGFB and genetic barcodes in mouse brain to initiate gliomagenesis and enable direct tracing of glioblastoma evolution from its earliest possible stage. Unexpectedly, we observe a high incidence of clonal exti...

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Veröffentlicht in:	Cancer cell 2023-08, Vol.41 (8), p.1466-1479.e9
Hauptverfasser:	Ceresa, Davide, Alessandrini, Francesco, Lucchini, Sara, Marubbi, Daniela, Piaggio, Francesca, Mena Vera, Jorge Miguel, Ceccherini, Isabella, Reverberi, Daniele, Appolloni, Irene, Malatesta, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer dynamics computational model Gene Expression Profiling Glioblastoma - genetics Glioblastoma - pathology Glioblastoma evolution Glioma - genetics Lineage tracing coupled to scRNA-seq Mice Myc-driven cell-cell competition PDGFB mouse glioma model Phenotype Retrospective Studies Tumor clonal dynamics
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