Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy

Aspirin and platelet P2Y12 inhibitors, such as ticagrelor, suboptimally inhibit microvascular thrombosis during ST-elevation myocardial infarction. Glycoprotein (GP) IIb/IIIa inhibitors may further inhibit this but cause excessive bleeding. We investigated whether combination of glenzocimab, a GPVI...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2023-11, Vol.21 (11), p.3236-3251
Hauptverfasser:	Alenazy, Fawaz O., Harbi, Maan H., Kavanagh, Dean P., Price, Joshua, Brady, Paul, Hargreaves, Oscar, Harrison, Paul, Slater, Alexandre, Tiwari, Alok, Nicolson, Phillip L.R., Connolly, Derek L., Kirchhof, Paulus, Kalia, Neena, Jandrot-Perrus, Martine, Mangin, Pierre H., Watson, Steve P., Thomas, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute coronary syndromes antiplatelet therapy atherosclerotic plaque GPVI pharmacology platelets thrombosis translational studies
Online-Zugang:	Volltext
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