Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor
We investigated the association between altered levels of inflammatory proteins in the cervicovaginal fluid (CVF) and acute histologic chorioamnionitis (HCA) and funisitis in women with preterm labor (PTL). In this study, a total of 134 consecutive singleton pregnant women with PTL (at 23+0–34+0 wee...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2023-09, Vol.169, p.156308-156308, Article 156308 |
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| container_title | Cytokine (Philadelphia, Pa.) |
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| creator | Park, Kyo Hoon Lee, Kyong-No Oh, Eunji Im, Eun Mi |
| description | We investigated the association between altered levels of inflammatory proteins in the cervicovaginal fluid (CVF) and acute histologic chorioamnionitis (HCA) and funisitis in women with preterm labor (PTL).
In this study, a total of 134 consecutive singleton pregnant women with PTL (at 23+0–34+0 weeks) who delivered preterm (at 0.1). The area under the receiver operating characteristic curves of the aforementioned biomarkers ranged from 0.61 to 0.77 regarding each outcome. Notably, HCA risk significantly increased with increasing CVF levels of interleukin-8 and resistin (P for trend |
| doi_str_mv | 10.1016/j.cyto.2023.156308 |
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In this study, a total of 134 consecutive singleton pregnant women with PTL (at 23+0–34+0 weeks) who delivered preterm (at < 37 weeks) and from whom CVF samples were collected at admission were retrospectively enrolled. The CVF levels of haptoglobin, interleukin-6/8, kallistatin, lipocalin-2, matrix metalloproteinase (MMP)-8, resistin, S100 calcium-binding protein A8, and serpin A1 were determined using enzyme-linked immunosorbent assay. The placentas were histologically analyzed after delivery.
Multiple logistic regression analyses showed significant associations between elevated CVF interleukin-8 and resistin levels and acute HCA after adjusting for baseline covariates (e.g., gestational age at sampling). CVF haptoglobin, interleukin-6/8, kallistatin, MMP-8, and resistin levels were significantly higher in women with funisitis than in those without, whereas the baseline covariates were similar between the two groups (P > 0.1). The area under the receiver operating characteristic curves of the aforementioned biomarkers ranged from 0.61 to 0.77 regarding each outcome. Notably, HCA risk significantly increased with increasing CVF levels of interleukin-8 and resistin (P for trend < 0.05).
Haptoglobin, interleukin-6/8, kallistatin, MMP-8, and resistin were identified as potential inflammatory CVF biomarkers predictive of acute HCA and funisitis in women with PTL. Moreover, the risk severity of acute HCA may be associated with the degree of the inflammatory response in the CVF (particularly based on interleukin-8 levels).</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2023.156308</identifier><identifier>PMID: 37536223</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cervicovaginal fluid ; Funisitis ; Histologic chorioamnionitis ; Inflammatory proteins ; Preterm labor</subject><ispartof>Cytokine (Philadelphia, Pa.), 2023-09, Vol.169, p.156308-156308, Article 156308</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-684fe4dcab50fa2658ef97ce7e495448a4657896f36b3b567135bdb5d450b2893</citedby><cites>FETCH-LOGICAL-c356t-684fe4dcab50fa2658ef97ce7e495448a4657896f36b3b567135bdb5d450b2893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cyto.2023.156308$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37536223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Kyo Hoon</creatorcontrib><creatorcontrib>Lee, Kyong-No</creatorcontrib><creatorcontrib>Oh, Eunji</creatorcontrib><creatorcontrib>Im, Eun Mi</creatorcontrib><title>Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>We investigated the association between altered levels of inflammatory proteins in the cervicovaginal fluid (CVF) and acute histologic chorioamnionitis (HCA) and funisitis in women with preterm labor (PTL).
In this study, a total of 134 consecutive singleton pregnant women with PTL (at 23+0–34+0 weeks) who delivered preterm (at < 37 weeks) and from whom CVF samples were collected at admission were retrospectively enrolled. The CVF levels of haptoglobin, interleukin-6/8, kallistatin, lipocalin-2, matrix metalloproteinase (MMP)-8, resistin, S100 calcium-binding protein A8, and serpin A1 were determined using enzyme-linked immunosorbent assay. The placentas were histologically analyzed after delivery.
Multiple logistic regression analyses showed significant associations between elevated CVF interleukin-8 and resistin levels and acute HCA after adjusting for baseline covariates (e.g., gestational age at sampling). CVF haptoglobin, interleukin-6/8, kallistatin, MMP-8, and resistin levels were significantly higher in women with funisitis than in those without, whereas the baseline covariates were similar between the two groups (P > 0.1). The area under the receiver operating characteristic curves of the aforementioned biomarkers ranged from 0.61 to 0.77 regarding each outcome. Notably, HCA risk significantly increased with increasing CVF levels of interleukin-8 and resistin (P for trend < 0.05).
Haptoglobin, interleukin-6/8, kallistatin, MMP-8, and resistin were identified as potential inflammatory CVF biomarkers predictive of acute HCA and funisitis in women with PTL. Moreover, the risk severity of acute HCA may be associated with the degree of the inflammatory response in the CVF (particularly based on interleukin-8 levels).</description><subject>Cervicovaginal fluid</subject><subject>Funisitis</subject><subject>Histologic chorioamnionitis</subject><subject>Inflammatory proteins</subject><subject>Preterm labor</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kM1u1DAURi0EoqXwAiyQl2wyOP5LIrFBVaGVKrGBteXY1507JPZgO1PNA_DeZJjCko3te_V9R_Ih5G3LNi1r9Yfdxh1r2nDGxaZVWrD-Gbls2aAbtq6en95SNFJrfUFelbJjjA2i616SC9EpoTkXl-TXXQyTnWdbUz7SEdNs8w_IhWKkdQvUQT6gSwf7gNFONEwLeloTRQ-xYjjSLZaapvSAjrptypjsHDFFrFiojZ6GJWL5M63ExzTDemLd0n2GCnmmkx1Tfk1eBDsVePN0X5Hvn2--Xd8291-_3F1_um-cULo2upcBpHd2VCxYrlUPYegcdCAHJWVvpVZdP-gg9ChGpbtWqNGPykvFRt4P4oq8P3P3Of1coFQzY3EwTTZCWorhvdQD1yt5jfJz1OVUSoZg9hlXOUfTMnPSb3bmpN-c9Juz_rX07om_jDP4f5W_vtfAx3MA1l8eELIpDiE68JjBVeMT_o__GyXImdc</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Park, Kyo Hoon</creator><creator>Lee, Kyong-No</creator><creator>Oh, Eunji</creator><creator>Im, Eun Mi</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230901</creationdate><title>Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor</title><author>Park, Kyo Hoon ; Lee, Kyong-No ; Oh, Eunji ; Im, Eun Mi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-684fe4dcab50fa2658ef97ce7e495448a4657896f36b3b567135bdb5d450b2893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cervicovaginal fluid</topic><topic>Funisitis</topic><topic>Histologic chorioamnionitis</topic><topic>Inflammatory proteins</topic><topic>Preterm labor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Kyo Hoon</creatorcontrib><creatorcontrib>Lee, Kyong-No</creatorcontrib><creatorcontrib>Oh, Eunji</creatorcontrib><creatorcontrib>Im, Eun Mi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Kyo Hoon</au><au>Lee, Kyong-No</au><au>Oh, Eunji</au><au>Im, Eun Mi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>169</volume><spage>156308</spage><epage>156308</epage><pages>156308-156308</pages><artnum>156308</artnum><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>We investigated the association between altered levels of inflammatory proteins in the cervicovaginal fluid (CVF) and acute histologic chorioamnionitis (HCA) and funisitis in women with preterm labor (PTL).
In this study, a total of 134 consecutive singleton pregnant women with PTL (at 23+0–34+0 weeks) who delivered preterm (at < 37 weeks) and from whom CVF samples were collected at admission were retrospectively enrolled. The CVF levels of haptoglobin, interleukin-6/8, kallistatin, lipocalin-2, matrix metalloproteinase (MMP)-8, resistin, S100 calcium-binding protein A8, and serpin A1 were determined using enzyme-linked immunosorbent assay. The placentas were histologically analyzed after delivery.
Multiple logistic regression analyses showed significant associations between elevated CVF interleukin-8 and resistin levels and acute HCA after adjusting for baseline covariates (e.g., gestational age at sampling). CVF haptoglobin, interleukin-6/8, kallistatin, MMP-8, and resistin levels were significantly higher in women with funisitis than in those without, whereas the baseline covariates were similar between the two groups (P > 0.1). The area under the receiver operating characteristic curves of the aforementioned biomarkers ranged from 0.61 to 0.77 regarding each outcome. Notably, HCA risk significantly increased with increasing CVF levels of interleukin-8 and resistin (P for trend < 0.05).
Haptoglobin, interleukin-6/8, kallistatin, MMP-8, and resistin were identified as potential inflammatory CVF biomarkers predictive of acute HCA and funisitis in women with PTL. Moreover, the risk severity of acute HCA may be associated with the degree of the inflammatory response in the CVF (particularly based on interleukin-8 levels).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37536223</pmid><doi>10.1016/j.cyto.2023.156308</doi><tpages>1</tpages></addata></record> |
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| subjects | Cervicovaginal fluid Funisitis Histologic chorioamnionitis Inflammatory proteins Preterm labor |
| title | Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor |
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