Identification and characterization of T-cell receptors with therapeutic potential showing conserved specificity against all SARS-CoV 2 strains

Treatment of severe COVID-19 disease can be challenging in immunocompromized patients due to newly emerging virus variants of concern (VOC) escaping the humoral response. Thus, T cells recognizing to date unmutated epitopes are not only relevant for patients’ immune responses against VOC, but might...

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Veröffentlicht in:	Immunobiology (1979) 2023-09, Vol.228 (5), p.152720-152720, Article 152720
Hauptverfasser:	Reimann, Hannah, Moosmann, Carolin, Schober, Kilian, Lang, Vanessa, Verhagen, Johan, Zeun, Julia, Mackensen, Andreas, Kremer, Anita N., Völkl, Simon, Aigner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Orthotopic TCR replacement SARS-CoV-2 T-cell engineering T-cell therapy
Online-Zugang:	Volltext
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